2.Association between lung compliance phenotypes and mortality in COVID-19 patients with acute respiratory distress syndrome.
Ser Hon PUAH ; Matthew Edward COVE ; Jason PHUA ; Amit KANSAL ; Jonathen VENKATACHALAM ; Vui Kian HO ; Duu Wen SEWA ; Roshni Sadashiv GOKHALE ; Mei Fong LIEW ; Benjamin Choon Heng HO ; Jensen Jiansheng NG ; John A ABISHEGANADEN ; Yee Sin LEO ; Barnaby Edward YOUNG ; David Chien LYE ; Tsin Wen YEO
Annals of the Academy of Medicine, Singapore 2021;50(9):686-694
INTRODUCTION:
Acute respiratory distress syndrome (ARDS) in COVID-19 is associated with a high mortality rate, though outcomes of the different lung compliance phenotypes are unclear. We aimed to measure lung compliance and examine other factors associated with mortality in COVID-19 patients with ARDS.
METHODS:
Adult patients with COVID-19 ARDS who required invasive mechanical ventilation at 8 hospitals in Singapore were prospectively enrolled. Factors associated with both mortality and differences between high (<40mL/cm H
RESULTS:
A total of 102 patients with COVID-19 who required invasive mechanical ventilation were analysed; 15 (14.7%) did not survive. Non-survivors were older (median 70 years, interquartile range [IQR] 67-75 versus median 61 years, IQR 52-66;
CONCLUSION
COVID-19 ARDS patients with higher compliance on the day of intubation and a longitudinal decrease over time had a higher risk of death.
COVID-19
;
Humans
;
Lung Compliance
;
Phenotype
;
Respiratory Distress Syndrome/therapy*
;
SARS-CoV-2
Result Analysis
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