Introduction: By the theory of traditional medicine the “wind, bile, phlegm” are all together been in whole human body, “speech“ and “mind properties” and their role is to regulate with normal function and pathology of the human body, diagnostic and therapeutically activity. 1 Traditional medical body constitutional types classified into “wind-, bile-, phlegm-dominated” (separately 3 types), combined types within 2 elements (“wind-bile, wind-phlegm, bile-phlegm”), and mixed (“wind-bile-phlegm”) type. There are totally 7 types of traditional medical body constitution. 2. Traditional medicine regards man as an unity of human body,“speech“ and “mindproperties”, meanwhile modern medical science regards mentioned above terms separately by the huge meanings of morphology, physiology, psychiatry and psychology. Human body constitutions, anthropometrical determinant and features of stress are inextricably linked with each other so required to study them together as a complex situation. Objective of the research work: To determine correlation between traditional medical constitution and anthropometrical, psychological methods of human body study. Research material and methodology: For our work we chose some inpatients and relatively healthpeople,andconducttheepidemiological analytics research by cross-sectional method. 63-64 Result of research work: Among the all 500 people, who were involved in our research there were students, military personals, sportsmen and inpatients, admitted to a hospitals, at the departments of traditional medicine, respiratory, nephrology, gastrointestinal diseases and rehabilitation unit of Shastin’s central hospital and Traditional medical science technology and Production Corporation. From this 205 people or 41% were male, 295 or 59% - female. 63.2% for the people had obtained to our research, mostly have constitution combined both of the “windbile”, 98.4% (492 people) had suffered by stress from the total 500 people had obtained to the research and only 1.6% (8 persons) of people hadn’t had any stress situation. People with combined constitution of “wind-bile” mainly had a III level of stress as we compared body construction with a stress. The occurrence group`s 250 people had obtained to our research mostly have were the patients admitted to a hospital for treat and among them 24.8% of the patients mainly had a urogenital system pain and 21.6% of the patients mainly had a blood circulatory system pain as we show their sickness situation. People belong to “bile”, “phlegm” constitution mainly had a digestive system pain and the people belong to “bile”, “wind” `s constitution mainly had a urogenital system pain as we considered about organ system pain from a constitution of body construction point of view. Conclusion: 1. The people had obtained to our research, mostly have each constitution combined both of the “windbile” (63.2%), “bile-phlegm” (18.4%) and “windphlegm” (18.4%). 2. We also compared the human body weight amount with the previously defined “wind”, “bile”, “phlegm” amount in a human body (or given person) then we defined relevance between them. The “bilephlegm” combined constitution’s men body height average /1695.7±63.8/ is taller than “wind-phlegm” constitution’s men by 16.7 mm and “wind-bile” men by 21 mm, tne “bile-phlegm” combined constitution’s men body weigth’s /74.4±13.1/ heavier than “windphlegm” constitution’s men by 6 kg and “wind-bile” men by 7kg. 3. III level of stress was highest 43.6% percent and the IV level of the stress was lowest percent or 1.6%, as we conclude stress situation. 4. The highest amount of people (24.8%) mainly had a urogenital system problem and 21.6% of the people had blood circulatory system pathology among the occurrence group people had obtained to our research as we show their sickness situation.

Introduction: There is an increasing need to study traditional medical sourcebooks and explanatory materials to enrich and develop medical concepts and clinical practices. Objectives: To study Mongolians contribution of nomenclature, origin andclassification of precious medicine using traditional medical sourcebooks and explanatory materials. Results and conclusion: The sourcebook “The Four Medical Tantras”written 10 type of jewel and the sourcebook “Em tanikh ukhaan”hadreferred mentioned above brass and plumbum. Although, this book determined jewel medicines shape, function and treatment, how to know these jewel.In the sourcebook “Uzesgelent nuden chimeg” jewel had divided an not fluxible-25, fluxible-13. These scientists medicinal prescriptions knowledge were shown greatly consideration in Mongolian traditional medicine.

Foreword: There is a demand to compare traditional medicine with modern medical science so that it will educate public for proper usage of natural traditional medicine such as main concept, identifying medical plants, reducing its volume, taste etc...1We mainly concentrated on comparisement of Mongolian religious healers books and chose following books for our research work that are “Thefour basic medicine” by Yutig Yondongombo Tibeten doctor and 2 other books by Mongolian doctor Luvsanchultem and Jambaldorj. Methods we used are analyzing, summarizing, comparing and classifying. According to a book “The four basic medicine” the animal starch includes horn, bone, meat, blood, gall, fat, brain, skin, nail, hair, urine, litter and body. Also, the book states their potential healing power. In a book named “Beautification” it says there are11 medicine comes from human and 124 medicine comes from animals and detailed classification is stated here. “Medicine identifying science” by Luvsanchultem Tsakhar gevsh (monastic title for a learned lama) says that there are 54 animal starch medicineand it shows us how to be aware of recognition and not to be mistaken. Here popular medicine are determined how to find out that is in good or bad condition, so that made it easier for us to identify and contributed greatly to Mongolian medical science.

Introduction: This plants distributed about 2500 species in worldwide and 69 species of those grow in Mongolia. In case of medicinal application of this plant is commonly used traditional medicine in European and Asian. For example, the different preparations of Astragalus mongholicus root, the most commonly used Astragalus species in Chinese medicine. Other Astragalus species which are being investigated for their anti-cancer properties are the Turkish species, and include Astragalus brachypterus, Astragalus cephalotes, Astragalus microcephalus and Astragalus trojanus. Astragalus mongholicus.Bunge. Traditional Uses: The taste is sweet and the potency is hot. It is used for the following: treating light swelling, water swelling and phlegm, and improving physical energy and strength. It is also used to soothe a purulent inflammation, for wound-healing, to treat lung fever, oliguria and hemorrhoids. It is an ingredient of the following traditional prescription: Jurur-6 Chemical constituents: Root contains flavonoids: formononetin, 3-hydroxy-formononetin, 2,3- dihydroxy- 7,4-dimethoxyflavone, 7,3-dihydroxy-4-methoxyflavone 7-O- glucoside, 7,3-dihydroxy-4- dimethoxyflavone, saponins: astragaloside I-X, isoastragaloside I-IV, polysaccharides, Above- ground parts contain astragaloside quercetin, isorhamnetin, rhamnocetin, isorhamnetin 3-b-Dglucopyranoside, propingoside, coumarin, tannins, and saponins. Qualitative and quantitative assays: Flavonoids in the plant are identified by cyanidin reaction and reaction with lead tetraacetate. Total flavonoid content is determined by spectrophotometry at 430 nm and calculated as quercetin. Qualitative and quantitative standards: Loss on drying, 8.0%. Organic matter, not more than 0.5% and mineral matter, not more than 1.0%. Total flavonoid content, not less than 3.0%.

Монгол улсад элэгний хавдрын өвчлөл ихсэх хандлагатай байгаа бөгөөд эмийн эмчилгээнд гаж нөлөө багатай ургамлын гаралтай эм хэрэглэх хандлага нэмэгдэж энэ чиглэлийн судалгаа эрчимтэй өрнөж байна. Бидний судалгааны ажлын зорилго нь Байгалийн гүүн хөх Scutellaria baicalensis (Georgi) ургамлын хандны элэгний хавдрын эсэд үзүүлэх нөлөөг in vitro орчинд судлан тогтоох явдал юм. Байгалийн гүүн хөх Scutellaria baicalensis (Georgi) ургамлаас гаргаж авсан этанолын ханд элэгний анхдагч өмөнгийн эсэд дарангуйлах нөлөөтэй байх магадлалтай. Судалгаанд элэгний хавдрын анхдагч эсийн өсгөвөр-PCC, нохойн бөөрний MDCK шугаман эс болон Байгалийн гүүн хөх Scutellaria baicalensis (Georgi) ургамлын газрын дээд хэсгийн этанолон ханд, Scutellaria baicalensis (Georgi) ургамлын үндэсний этанолон хандаас ялгасан Skullcap бэлдмэлийг ашиглав. Байгалийн гүүн хөх Scutellaria baicalensis (Georgi) ургамлын ханд болон Skullcap бэлдмэл нь эсийн геномын ДНХ-д нөлөөлж задрал, гэмтэл үзүүлээгүй. Харин нэгж эсээс ялгасан ДНХ-ийн концентраци харилцан адилгүй байгаа нь хандаар үйлчилсэний дараа амüд үлдсэн эсүүдийн тоотой шууд хамааралтай байх магадлалтай. Байгалийн гүүн хөх Scutellaria baicalensis (Georgi) ургамлын ханд болон Skullcap бэлдмэл нь шууд ДНХ-д нөлөөлөхгүй, өөр механизмаар эсийг үхэлд хүргэж байна. Бидний судалгаагаар Байгалийн гүүн хөх Scutellaria baicalensis (Georgi) ургамлын ханд 100 µg/ml бэлдмэл эсийн Bcl-2 генийн экспрессийг идэвхжүүлж 6%-иар байв. Skullcap бэлдмэл (100 µg/ml) 4,8 %, Байгалийн гүүн хөх Scutellaria baicalensis (Georgi) ургамлын ханд 13,2%-иар ZFYVE1 генийн экспрессийг дарангуйлж байна. 100 µg/ml концентраци бүхий бэлдмэл болон хандаар үйлчлэхэд тус бүр GAPDH генийн экспресс 13,4% ба 18,9%-иар тус тус дарангуйлагдсан. 100 µg/ml бэлдмэл болон хандаар GPR175 генийн экспрессийг 34,1% ба 41,5%-иар тус бүр дарангуйлж байв. Бидний судалгааны дүнд 100 µg/ml хандаар үйлчлэхэд GPC3 генийн экспресс илэрсэнгүй. Судалгаагаар эсийн апоптозийн процессийг гүйцэтгэгч CASP3 генийг олшруулах туршилтыг 3 давталттай явуулсан ч уг ген илэрсэнгүй.

Introduction:Influenza A viruses (IAV) are important pathogens that cause acute diseases in humans and domestic animals. In Mongolia only during 2010/2011 influenza season, there has been registered in average 1232 influenza like illness per 10.000 people, which is 5.8% of all the registered outpatient visits. Scutellaria baicalensis Georgi is one of the most widely used Mongolian Traditional Medicine that historically is used in anti-inflammation, anticancer, antiviral and antibacterial therapy. The goal of this study was to study antiviral effectiveness of Scutellaria baicalensis Georgi extract on the cells via in vitro. Methods:Water extracts of Scutellaria baicalensis Georgi were prepared from its rhizomes and herbs. To assess the antiviral properties, avian influenza virus isolate A/H3/Teal/Tunka/7/2010 was incubated at 37°C for 30min in presence and absence of plants and the drug extracts in various concentrations. Subsequently the concentration of infectious virus in each sample was determined by plaque assays. Neutralisation indexes and 90% plaque reduction concentrations had been estimated for each extract and significance of data obtained was evaluated using convenient statisticalmethods. Results:The extracts of Scutellaria baicalensis Georgi no significant toxicity, is well tolerated by Madin-Darby canine kidney cells at concentrations up to 1-0.25%. The extracts of Scutellaria baicalensis Georgi reduced the titer of A/Teal/Tunka/7/2010 (H3N8) by 50% (p≤0.05). The plaque reduction neutralization tests revealed that none of the extracts tested were able to inhibit 90% of plaques. However, extract ofScutellaria baicalensis Georgi, is able to inhibit more than 50% of plaques at low dilutions from 1:3 to 1:14 and the former two were expressing concentration- dependent inhibitory effect. Conclusion 1.Antiviral action of the extracts of Scutellaria baicalensis Georgiis detected. These extracts significantly reduced the infectiveness ofinfluenza A virus H3N8 in-vitro when used in high concentrations (1-0.25%). 2.Extract of Scutellaria baicalensis Georgi is well tolerated by Madin-Darby canine kidney cells at concentrations up to 0.94%.

Background: In 2021, 5981 of cancer new cases was registered in Mongolian population. Among those cases, liver cancer was commonly registered with a prevalence of 32.7%. Studies on anticancer agents with no-adverse effects and good-preventive efficacy against cancer have been attracted more attention from the researchers in the field of pharmaceutical sciences. Scutellaria baicalensis Georgi, Saussurrea amara.L, Chiazospermum erectum Berh, and Carthamus tinctorius.L are well recognized as effective agent against liver diseases. Using these raw materials, researchers have been invented a traditional prescription and named as Hepaclin-4. In this study, we aimed to investigate the qualitative study of raw materials and some biologically active sub- stances in the compounds. Purpose: To study the qualitative study of raw materials for Hepaclin-4 prescription Materials and methods: Some qualitative properties of raw materials for Hepaclin-4 prescription, including appearance, minerals, some organic compounds, total ash, water-soluble substances and fungi, were investigated according to Mongolian pharmacopeia and total flavonoid was detected by thin layer chromatography. Results: No changes were observed on the appearance of raw materials, and minerals and organic compounds weren’t detected in the prescription. No contamination with fungi and insects were identified. The moist in the raw materials were 5.9 to 8.1%, total ash was 4.7 to 13.3% and the water-soluble substances were detected 33.8 to 42.9%. Number of aerobic bacteria, fungi and E.coli, Salmonella species were detected in normal range, indicating that the prescription was matched with the requirement of pharmacopeia. According to the thin layer chromatography study of the raw materials, a yellow spot on the chromatogram were identified and same as quercetin (Rf=0.9-0.98) and rutin ((Rf=0.18-0.23)) as standard compounds, which indicated that the spot which indicated that the spot was flavonoids in the prescription. Conclusions These results showed that the appearance, moist, minerals, organic compound, water-soluble substances, ash and biologically active substances of the raw materials for Hepaclin-4 prescription was corresponded with the requirements of pharmacopeia, and flavonoid was detected in raw materials of Hepaclin-4.

Introduction: Scutellaria baicalensis Georgi, which is used in traditional medicine, has the ability to remove blood-drying heat. Chiazospermum erectum Bernh. has the ability to relieve typhoid fever and poison fever. Carthamus tinctorius L. has antiseptic, analgesic and anti-toxic properties. Saussurea amara L. has bactericidal, anti-infective, and anti-inflammatory properties. Researchers found that the Hepaclin-4 recipe has antioxidant, membrane-strengthening, liver-protective, necrosis-preventing, detoxification, and peroxidation product accumulation-reducing properties. Therefore, extracting the granular medicine form from the concentrated extract containing the Hepaclin-4 formulation is the basis of our research work. Goal: To obtain the granular medicine form from the concentrated extract containing ingredients of the Hepaclin-4 recipe. Materials and Methods: The research was carried out with the support of the Institute of Pharmaceutical Research and the University of Pharmaceutical Sciences. The raw materials for the Hepaclin-4 formula were extracted by remaceration with water, 40% ethanol, and 70% ethanol (1:10 ratio). Six types of granules were extracted from the concentrated extract using several excipients by the wet granulation method, and the pouring weight and flowability were determined. Results: The quality index of the concentrated extract of the Hepaclin-4 recipe complies with the standards outlined in the 11th Pharmacopoeia of the National Pharmacopoeia of Mongolia. In qualitative analysis of total flavonoid, spots were detected at the same level as standard quercetin (Rf=0.88) and rutin (Rf=0.4), indicating the presence of flavonoids. According to the results of the above research, lactose was found to be the suitable filler for extracting granules, and starch at 8% was identified as the appropriate binding agent from the concentrated extract of the Hepaclin-4 formula. Conclusion It was found suitable to select 8% lactose as a filler and starch as a binding agent from the concentrated extract of the Hepaclin-4 formula and obtain a granule drug form using the wet granulation method.