1.Results of treating closed fracture of 1/3 of clavicle by improved No8 plaster dressing at Thai Nguyen Centre Hospital
Journal of Practical Medicine 2003;425(5):19-20
Improved No8 plaster dressing was used in Thai Nguyen Centre Hospital from August 2001 to August 2002. Results were as follows: 56/56 subjects ahd good fixation without secondary dislocations, without other complications. After the procedure, shoulder joints got good movements. Good results were comfirmed by X-ray examinations
Clavicle
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Casts, Surgical
;
Therapeutics
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Fractures, Closed
2.Resting heart rate control and prognosis in coronary artery disease patients with hypertension previously treated with bisoprolol: a sub-group analysis of the BISO-CAD study.
Yun-Dai CHEN ; Xin-Chun YANG ; Vinh Nguyen PHAM ; Shi-An HUANG ; Guo-Sheng FU ; Xiao-Ping CHEN ; Binh Quang TRUONG ; Yu YANG ; Shao-Wen LIU ; Tian-Rong MA ; Dong-Soo KIM ; Tae-Hoon KIM
Chinese Medical Journal 2020;133(10):1155-1165
BACKGROUND:
Resting heart rate (RHR) is considered as a strong predictor of total mortality and hospitalization due to heart failure in hypertension patients. Bisoprolol fumarate, a second-generation beta-adrenoreceptor blockers (β-blocker) is commonly prescribed drug to manage hypertension. The present study was to retrospectively evaluate changes in the average RHR and its association with cardiovascular outcomes in bisoprolol-treated coronary artery disease (CAD) patients from the CAD treated with bisoprolol (BISO-CAD) study who had comorbid hypertension.
METHODS:
We performed ad-hoc analysis for hypertension sub-group of the BISO-CAD study (n = 866), which was a phase IV, multination, multi-center, single-arm, observational study carried out from October 2011 to July 2015 across China, South Korea, and Vietnam. Multivariate regression analysis was used to identify factors associated with incidence of composite cardiac clinical outcome (CCCO), the results were presented as adjusted odds ratio (OR) along with 95% confidence interval (CI) and adjusted P value.
RESULTS:
A total of 681 patients (mean age: 64.77 ± 10.33 years) with hypertension from BISO-CAD study were included in the analysis. Bisoprolol improved CCCOs in CAD patients with comorbid hypertension, with RHR <65 and <70 beats/min compared with RHR ≥65 and ≥75 beats/min, respectively, in the efficacy analysis (EA) set. In addition, it lowered RHR in both intent-to-treat (ITT) and EA groups after 6, 12, and 18 months of treatment. Further, RHR 70 to 74 beats/min resulted in significantly higher risk of CCCOs EA set of patients (adjusted OR: 4.34; 95% CI: 1.19-15.89; P = 0.03). Also, events of hospitalization due to acute coronary syndrome were higher when RHR 69 to 74 beats/min compared to RHR <69 beats/min in ITT patients.
CONCLUSION
Bisoprolol can effectively reduce RHR in Asian CAD patients with comorbid hypertension and hence, improve CCCO without affecting their blood pressure.