Perform total research 4-fluoroisothiocyanat by dithiocarbamat method, test antibacterial, anti fungus effect by dilute in slate method. Result showed: by response between 4-fluoroanilin and CS2 in ammoniac environment get 4-fluorophenyl dithiocarbamat, which response with lead get 4-fluoro-isothiocyanat. 4-fluorothioure partial towards antifungus, weakly effect in test bacterium
chemical synthesis ; Anti-Bacterial Agents ; Antibiotics, Antifungal ; drugs

The synthesis of some flourosalicylanilid derivatives and the study on their antifungal activities were performed as regard the synthesis: Acid- 4 aminosalcylic was diazoidized, then reacted to NaBF4 solution- Acid 4- flourosalicyanilid was created. Acid 4- fluorosalicylic and salicylic acid were condensed to aniline derivatives for creating 9 derivatives of fluorosalicylic. The synthetized substances were purified, fusion point and thin layer chronatography were determined. In products antibacterial inanifested and antifungal were in experimental concentration. Relatively strong activity of 3'- flourosalicyanilid had exerted on S. aureus; MRSA at the concentration of 9 microgram/ml and 18 microgram/ml; and 3'- flourosalicyanilid, 4'- flourosalicyanilid reacted relatively strongly on Microsporum nanum, Trichophyton mentagrophyle. Microsporum gypseum at the concentration of 2 microgram/ml and microgram/ml
Pharmaceutical Preparations ; Antifungal Agents ; Anti-Bacterial Agents

The report suggested that the ways to synthesize substances belong to 4-bromothioure derivatives. By reaction between 4-broucroanilin and CS2 in amoniac environment, collected 4 bromophenyl dithiocarbamat. This substance react with nitrate lead and collected 4 flurothiocyanate, and then can synthesize above substance. Synthesized substances were measured pure level, defined it's physico-chemical constants as well as structure. For antibacterial and anti-fungus, the trial will have result when 3 microfungal strains and 3 bacterial strains contact with 4-bromothioure derivative
Anti-Bacterial Agents ; Antibiotics, Antifungal ; analogs & derivatives ; drugs

Study was performed on the preparation of taurine and some taurate salts in the bile of cow/ox from vissan but chery firm. Average weight of bile adder get 80 g for each. From ethamlanin and die thylcarbonate, 2- oxzolidinon was prepared, after the heating with hydrogene sulphide, taurine was obtained with a productivity of 67,15%. The investigation and extraction of taurine in laboratory scale gave a productivity of 64,5%. From taurine, calcium taurate was prepared at a productivity of 90% and magnesium taurate- 83,5%
Taurine ; Salts ; Pharmaceutical Preparations

Condensation of salicylic acid with anilines made salicylanilid derivatives. From salicylanilids, 3-phenyl-2H-1, 3-benzoxazin-2, 4(3H)-dion derivatives were created by same circle reaction. Thionylation reaction 3-phenyl-2H-1, 3-benzoxazin-2,4(3H)-dion in dioxan solvent had good result. Products of thionylation created thiosalicylanilides after circle opened hydrolysis. Clearness of thiosalicylanilides was determined by thin layer chromatography and their structure was determined by UV, IR.H1 MNR. Antibacterial effect of synthetic products, especially Streptococcus feacalis E.coli was higher than control substance as salicylanilid. Antifungal effect of Bromo and clorothiosalicylanilide derivatives was stronger than other derivatives
Anti-Bacterial Agents ; Plants, medicinal

3-thioxo-3-arylamido-4-oxo-1,3thiazan derivatives were obtained by method dithiocarbamat. Condensation of 2-thioxo-3-arylamido-4-oxo-1,3-thiazan derivatives with phenylhydrazin to get 2-thioxo-3-arylamido-4-phenylhydranzon-1,3-thiazan derivatives. The structures of the obtained products were determined by elemental analysis and IR spectroscopy. The study indicated that most of them had low antibacterial and antifungal activities.
Chemical synthesis ; Analogs & derivatives

By condensation of phenylisothiocyanate with amine compounds, thioure derivatives were obtained. The structures of the obtained products were determined by elemental analysis and IR spectroscopy. The study indicated that most of them had antibacterial and anti-fungal activities. Two compounds have good effect on Candida albicans
Chemical synthesis ; Antifungal Agents

Mequinol is a depigmenting (or demelanizer). It was syntheized from hydroquinol and methyliodid or dimethylsulfate, that are available materials. Method is simple and suistable to condition in Vietnam. The structure of the obtained product was characteritsed by chromatography, UV, IR and elemental analysis.
Chemical synthesis ; 4-hydroxyanisole

Four heterocyclic salicylamine derivatives were prepared by condensing of aminoheterocyclic compounds with salicylic acid or its derivatives. The structure of the obtained products were determined by elemental analysis and IR spectroscopy. The sudy indicated that most of them had grater antibacterial and antifungal activities than salicylamide, but all of them did not have effect on Candida albicans.
Chemical synthesis ; Analogs & derivatives ; Salicylic Acid

Using sorbitol - a cheap and easy-to-find material in Vietnam, the authors built a relative optimal and complete protocol to synthesize isosorbide and isosorbide dinitrate (productivity of 64%). Test purity isosorbide dinitrate and solution of 25% isosorbide dinitrate. With purity isosorbite dinitrate: qualitative analysis by IR and test by HPLC method were conducted; isosorbide dinitrate solution was test according to USP 24 and checked by this standard. All products meet USP 24 standard
Isosorbide Dinitrate ; Sorbitol