From the cow's bile, which is by product of food manufacture installations in Ho Chi Minh city, was surveyed and built up a progress for isolating cholic acide. From cholic acide by five steps obtained chenodeoxycholic acide. The product come up to the standard of BP 2000
Cholic Acid ; Animal Experimentation ; Chenodeoxycholic Acid

Perform total research 4-fluoroisothiocyanat by dithiocarbamat method, test antibacterial, anti fungus effect by dilute in slate method. Result showed: by response between 4-fluoroanilin and CS2 in ammoniac environment get 4-fluorophenyl dithiocarbamat, which response with lead get 4-fluoro-isothiocyanat. 4-fluorothioure partial towards antifungus, weakly effect in test bacterium
chemical synthesis ; Anti-Bacterial Agents ; Antibiotics, Antifungal ; drugs

The synthesis of some flourosalicylanilid derivatives and the study on their antifungal activities were performed as regard the synthesis: Acid- 4 aminosalcylic was diazoidized, then reacted to NaBF4 solution- Acid 4- flourosalicyanilid was created. Acid 4- fluorosalicylic and salicylic acid were condensed to aniline derivatives for creating 9 derivatives of fluorosalicylic. The synthetized substances were purified, fusion point and thin layer chronatography were determined. In products antibacterial inanifested and antifungal were in experimental concentration. Relatively strong activity of 3'- flourosalicyanilid had exerted on S. aureus; MRSA at the concentration of 9 microgram/ml and 18 microgram/ml; and 3'- flourosalicyanilid, 4'- flourosalicyanilid reacted relatively strongly on Microsporum nanum, Trichophyton mentagrophyle. Microsporum gypseum at the concentration of 2 microgram/ml and microgram/ml
Pharmaceutical Preparations ; Antifungal Agents ; Anti-Bacterial Agents

The report suggested that the ways to synthesize substances belong to 4-bromothioure derivatives. By reaction between 4-broucroanilin and CS2 in amoniac environment, collected 4 bromophenyl dithiocarbamat. This substance react with nitrate lead and collected 4 flurothiocyanate, and then can synthesize above substance. Synthesized substances were measured pure level, defined it's physico-chemical constants as well as structure. For antibacterial and anti-fungus, the trial will have result when 3 microfungal strains and 3 bacterial strains contact with 4-bromothioure derivative
Anti-Bacterial Agents ; Antibiotics, Antifungal ; analogs & derivatives ; drugs

Study was performed on the preparation of taurine and some taurate salts in the bile of cow/ox from vissan but chery firm. Average weight of bile adder get 80 g for each. From ethamlanin and die thylcarbonate, 2- oxzolidinon was prepared, after the heating with hydrogene sulphide, taurine was obtained with a productivity of 67,15%. The investigation and extraction of taurine in laboratory scale gave a productivity of 64,5%. From taurine, calcium taurate was prepared at a productivity of 90% and magnesium taurate- 83,5%
Taurine ; Salts ; Pharmaceutical Preparations

Condensation of salicylic acid with anilines made salicylanilid derivatives. From salicylanilids, 3-phenyl-2H-1, 3-benzoxazin-2, 4(3H)-dion derivatives were created by same circle reaction. Thionylation reaction 3-phenyl-2H-1, 3-benzoxazin-2,4(3H)-dion in dioxan solvent had good result. Products of thionylation created thiosalicylanilides after circle opened hydrolysis. Clearness of thiosalicylanilides was determined by thin layer chromatography and their structure was determined by UV, IR.H1 MNR. Antibacterial effect of synthetic products, especially Streptococcus feacalis E.coli was higher than control substance as salicylanilid. Antifungal effect of Bromo and clorothiosalicylanilide derivatives was stronger than other derivatives
Anti-Bacterial Agents ; Plants, medicinal

4-chloroanilline, 5-chlorosalicylanilid and 3,5-dichlorosalicylic acid are obtained by chlorination aniline and salicylic acid in difference conditions. Condensation of the above compounds with aniline, salicylic acid and each other to get chlorosalicylanilid derivatives. Chlorosalicylanilid derivatives have high antibiotic and antifungal activity. All most of chlorosalicylanilid derivatives has low toxicity.
Drug Compounding ; chemical synthesis

5 thiourea derivatives were synthesized by condensation of 4- chlorophenylisothiocyanat with p-aminobenzoic acide and its derivatives. Condensation of 4-chlorophenylisothiocyanat with phenylhydrazine derivatives to give 2 thiosemicarbazid derivatives. The structure of the obtained products was determined by elementary analysis and IR spectroscopy. The study indicated that all of them have effect on bacteria Gram (+) but this effect on Gram (-) bacteria was weaker. All most of them have effect on Microsporum gypseum and Tricophyton mentagrophytes. Two compounds have effect on candida albicans.
Drug Compounding ; Antifungal Agents ; Anti-Bacterial Agents

Condensation of 4-chlorophenylisocyanat with amine compounds (p-amino salicylic acide, phenyl hydrazine derivatives) gets 7 thiourea derivatives. The structures of the obtained products were determined by elemental analysis and IR spectroscopy. The study indicated that all of them have strong effect on bacteris Gram(+) but weak on GR(-). Six compounds have affected on Microsporum gypseum and Tricophyton mentagrophytes. Two compounds have effects on Candida albicans.
Antifungal Agents ; Anti-Bacterial Agents ; Drug Compounding

O- and m-phenylen diamin obtained by nitration and reduction of aniline and nitrobenzene. From amin compounds and by dithiocarbamat method synthesized isothiocyanat derivatives: Condensation of phenylendiisothiocyanat derivatives with amine compounds (p-aminosalicylic acid, p-aminobenzoic acid and their derivatives) to get 11 dithiourea derivatives. The purity of the products were controlled by the layer chromatography. The structures of them were determined by elemental analysis and IR spectroscopy, 1HNMR. The study indicated that all of them have strong effect on fungal strains except Candida albicans, Aspergillus niger and Aspergillus flavus. Some are stronger than ketoconazol.
Phenylenediamines ; 3-phenylenediamine ; 1,2-diaminobenzene ; diphenylthiourea