Condensation of salicylic acid with anilines made salicylanilid derivatives. From salicylanilids, 3-phenyl-2H-1, 3-benzoxazin-2, 4(3H)-dion derivatives were created by same circle reaction. Thionylation reaction 3-phenyl-2H-1, 3-benzoxazin-2,4(3H)-dion in dioxan solvent had good result. Products of thionylation created thiosalicylanilides after circle opened hydrolysis. Clearness of thiosalicylanilides was determined by thin layer chromatography and their structure was determined by UV, IR.H1 MNR. Antibacterial effect of synthetic products, especially Streptococcus feacalis E.coli was higher than control substance as salicylanilid. Antifungal effect of Bromo and clorothiosalicylanilide derivatives was stronger than other derivatives
Anti-Bacterial Agents ; Plants, medicinal

4-chloroanilline, 5-chlorosalicylanilid and 3,5-dichlorosalicylic acid are obtained by chlorination aniline and salicylic acid in difference conditions. Condensation of the above compounds with aniline, salicylic acid and each other to get chlorosalicylanilid derivatives. Chlorosalicylanilid derivatives have high antibiotic and antifungal activity. All most of chlorosalicylanilid derivatives has low toxicity.
Drug Compounding ; chemical synthesis

5 thiourea derivatives were synthesized by condensation of 4- chlorophenylisothiocyanat with p-aminobenzoic acide and its derivatives. Condensation of 4-chlorophenylisothiocyanat with phenylhydrazine derivatives to give 2 thiosemicarbazid derivatives. The structure of the obtained products was determined by elementary analysis and IR spectroscopy. The study indicated that all of them have effect on bacteria Gram (+) but this effect on Gram (-) bacteria was weaker. All most of them have effect on Microsporum gypseum and Tricophyton mentagrophytes. Two compounds have effect on candida albicans.
Drug Compounding ; Antifungal Agents ; Anti-Bacterial Agents

Condensation of 4-chlorophenylisocyanat with amine compounds (p-amino salicylic acide, phenyl hydrazine derivatives) gets 7 thiourea derivatives. The structures of the obtained products were determined by elemental analysis and IR spectroscopy. The study indicated that all of them have strong effect on bacteris Gram(+) but weak on GR(-). Six compounds have affected on Microsporum gypseum and Tricophyton mentagrophytes. Two compounds have effects on Candida albicans.
Antifungal Agents ; Anti-Bacterial Agents ; Drug Compounding

O- and m-phenylen diamin obtained by nitration and reduction of aniline and nitrobenzene. From amin compounds and by dithiocarbamat method synthesized isothiocyanat derivatives: Condensation of phenylendiisothiocyanat derivatives with amine compounds (p-aminosalicylic acid, p-aminobenzoic acid and their derivatives) to get 11 dithiourea derivatives. The purity of the products were controlled by the layer chromatography. The structures of them were determined by elemental analysis and IR spectroscopy, 1HNMR. The study indicated that all of them have strong effect on fungal strains except Candida albicans, Aspergillus niger and Aspergillus flavus. Some are stronger than ketoconazol.
Phenylenediamines ; 3-phenylenediamine ; 1,2-diaminobenzene ; diphenylthiourea

p-phenylendiamin was obtained by the nitration, hydrolysis and reduction of acetanilide. The reaction between p-phenylendiamin and CS2 in ammoniac solution produced p-phenylen bis-dithiocarbamat, which was performed oxidatively with lead nitrat and was converted into p-phenylendiisothiocyanat. -Condensation of 1,4-phenylendiisothiocyanat with amine compounds (p-aminosalicylic acide, p-aminobenzoic acide and their derivatives to get 10 dithiourea dervatives. -The purity of products were controlled by thin layer chromatography. The structures of them were determined by elemental analysis and IR spectroscopy. -The study indicated that all of them have strong antifunggal properpies but weak effect on bacteria
Antifungal Agents ; Anti-Bacterial Agents ; Pharmaceutical Preparations

3-thioxo-3-arylamido-4-oxo-1,3thiazan derivatives were obtained by method dithiocarbamat. Condensation of 2-thioxo-3-arylamido-4-oxo-1,3-thiazan derivatives with phenylhydrazin to get 2-thioxo-3-arylamido-4-phenylhydranzon-1,3-thiazan derivatives. The structures of the obtained products were determined by elemental analysis and IR spectroscopy. The study indicated that most of them had low antibacterial and antifungal activities.
Chemical synthesis ; Analogs & derivatives

By condensation of phenylisothiocyanate with amine compounds, thioure derivatives were obtained. The structures of the obtained products were determined by elemental analysis and IR spectroscopy. The study indicated that most of them had antibacterial and anti-fungal activities. Two compounds have good effect on Candida albicans
Chemical synthesis ; Antifungal Agents

Mequinol is a depigmenting (or demelanizer). It was syntheized from hydroquinol and methyliodid or dimethylsulfate, that are available materials. Method is simple and suistable to condition in Vietnam. The structure of the obtained product was characteritsed by chromatography, UV, IR and elemental analysis.
Chemical synthesis ; 4-hydroxyanisole

Four heterocyclic salicylamine derivatives were prepared by condensing of aminoheterocyclic compounds with salicylic acid or its derivatives. The structure of the obtained products were determined by elemental analysis and IR spectroscopy. The sudy indicated that most of them had grater antibacterial and antifungal activities than salicylamide, but all of them did not have effect on Candida albicans.
Chemical synthesis ; Analogs & derivatives ; Salicylic Acid