Treatment of acute lymphoid leukemia at the Center of Hematology and Blood Transfusion of Ho Chi Minh city. A ten-year survey 1990-2000. Among 1,317 patients diagnosed as ALL during the past ten years, 197 of them have followed a full-term treatment according to either BGMT protocol, for adults, or FRALLE, for children. The percentage of patients achieving CR is comparable to foreign authors, but the DFS of our patients is clearly lower: 45% (5 years) and the Medicum Remission Duration (MRD) is 48 months for children and DFS = 35% (5 years) MRD = 9 months for adults. Risk factors influence significantly on the issue of therapy; children have better prognosis than adults; patients who have myelois cell marker(s) get poorer result than those who have not. Relapse occurs mostly in the bone marrow, rather than neuro-menigeal and gonadic sites.
Leukemia, Lymphocytic, Acute ; therapy ; therapeutics