Adult ; Ferritins ; blood ; Humans ; Leukocytes ; metabolism ; Lymphohistiocytosis, Hemophagocytic ; blood ; diagnosis ; Male ; Panniculitis ; blood ; diagnosis ; Triglycerides ; blood

OBJECTIVETo investigate the relationship between fasting serum levels of leptin, glucose, insulin resistance, lipids in simple obese children.

METHODSFasting serum levels of leptin and insulin (Fins) were measured by RIA in 42 obese and 42 normally-weighted children matched on age, sex and height, and their total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C) were analyzed with enzymatic methods. HOMA-IR and LDL-C were calculated.

RESULTSSerum level of leptin was (2.74 - 45.12) micro g/L and (0.53 - 10.18) micro g/L in obese and normally-weighted children, respectively, with an average level of leptin (log) significantly higher in obese group than that in control group (P < 0.001). Serum level of leptin was positively correlated with BMI, WHR and percentage of body fat. Of obese children, 83% were leptin resistant. Serum levels of TC, TG, LDL-C and insulin were significantly higher in obese leptin-resistant group than those in normally-weighted control group, but no significant difference in them between obese leptin-sensitive group and its normally-weighted control group was observed. Significantly higher serum levels of TG and lower HDL-C were observed in obese leptin-resistant group, as compared with those in obese leptin-sensitive group.

CONCLUSIONSA big difference in serum level of leptin between obese and normally-weighted children was found, suggesting most obese children were resistant to endogenous leptin. Leptin resistance correlated significantly with the risk of metabolic syndrome and cardiovascular disease, indicating serum level of leptin could be used as an indicator in screening obese children at high risk.

Blood Glucose ; metabolism ; Body Mass Index ; Child ; Cholesterol ; blood ; Female ; Humans ; Insulin Resistance ; Leptin ; blood ; Male ; Obesity ; blood ; Triglycerides ; blood

Over the last two decades, significant research attention has been given to the acute effect of a single bout of exercise on postprandial lipaemia. A large body of evidence supports the notion that an acute bout of aerobic exercise can reduce postprandial triacylglycerol (TAG) concentrations. However, this effect is short-lived emphasising the important role of regular physical activity for lowering TAG concentrations through an active lifestyle. In 1995, the concept of accumulating physical activity was introduced in expert recommendations with the advice that activity can be performed in several short bouts throughout the day with a minimum duration of 10 minutes per activity bout. Although the concept of accumulation has been widely publicised, there is still limited scientific evidence to support it but several studies have investigated the effects of accumulated activity on health-related outcomes to support the recommendations in physical activity guidelines. One area, which is the focus of this review, is the effect of accumulating exercise on postprandial lipaemia. We propose that accumulating exercise will provide additional physical activity options for lowering postprandial TAG concentrations relevant to individuals with limited time or exercise capacity to engage in more structured forms of exercise, or longer bouts of physical activity. The benefits of accumulated physical activity might translate to a reduced risk of cardiovascular disease in the long-term.
*Exercise ; Humans ; Hyperlipidemias/metabolism/pathology/*prevention & control ; Lipid Metabolism ; Postprandial Period ; Triglycerides/blood

OBJECTIVETo observe the impacts of different time of moxibustion on its regulating lipid effects and safety of hyperlipidemia.

METHODSSeventy-six cases of hyperlipidemia patients were randomly divided into three groups: including moxibustion 10 min group (group A, 25 cases), moxibustion 20 min group (group B, 25 cases) and moxibustion 30 min group (group C, 26 cases). All of these three groups choose the same acupoints, Shenque (CV 8),Zusanli (ST 36), Fenglong (ST 40) and Sanyinjiao (SP 6) were selected. These three groups were treated with moxibustion for 10 min, 20 min and 30 min, respectively, three times a week, 12 times constituted one course, two courses were required for each group. All indices of blood lipid and fasting blood glucose were observed before and after treatment, and the preliminary evaluation was made on the safety of hepatic and renal function.

RESULTSThere were significant decrease in total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), and blood sugar after moxibustion treatment (all P<0.001), there was no significant difference of high density lipoprotein cholesterol (HDL-C) before and after treatment (P>0.05). The group C played more prominent role than group A in regulating the TC (P<0.01) and LDL-C (P<0.05), there was no significant difference between group C and group B (P>0.05). The blood urea nitrogen(BUN) was significantly reduced after moxibustion treatment (P<0.05), and there were no significant differences of other safety indices before and after treatment (all P>0.05).

CONCLUSIONMoxibustion can effectively and safely reduce the blood lipid level of hyperlipidemia patients, the decreasing degree of lipid is different with different time of moxibustion after treatment, and the decreasing degree in moxibustion 30 min group is significantly better than that in moxibustion 10 min group.

Acupuncture Points ; Aged ; Blood Glucose ; metabolism ; Cholesterol ; blood ; Female ; Humans ; Hyperlipidemias ; blood ; therapy ; Male ; Middle Aged ; Moxibustion ; Triglycerides ; blood

OBJECTIVETo determine the serum levels of lipid and glucose in patients with periodontitis.

METHODSThe patients with aggressive periodontitis (AgP, n = 117) and chronic periodontitis (CP, n = 40) and healthy controls (n = 37) were recruited. Peripheral blood sample was obtained from each subject by venipuncture. Serum chemistry variables including total cholesterol, triglycerides, and fasting glucose were analyzed by biochemical analyzer.

RESULTSThe average serum levels of triglycerides and glucose of the patients with AgP [(1.09 +/- 0.79) mmol/L and (5.07 +/- 0.66) mmol/L] were both significantly higher than those of the control group [(0.94 +/- 0.28) mmol/L and (4.62 +/- 0.64) mmol/L], P < 0.05. Higher serum levels of total cholesterol and glucose were also observed in patients with CP [(4.61 +/- 1.23) mmol/L and (5.40 +/- 1.01) mmol/L] compared with controls [(4.49 +/- 0.78) mmol/L and (4.62 +/- 0.64) mmol/L], P < 0.05. Serum level of total cholesterol in AgP group was positively associated with percentage of severe sites (r = 0.25, P < 0.01).

CONCLUSIONSPatients with periodontitis may have altered serum lipid and glucose levels compared with controls.

Adolescent ; Adult ; Blood Glucose ; metabolism ; Cholesterol ; blood ; Female ; Humans ; Male ; Middle Aged ; Periodontitis ; blood ; Triglycerides ; blood ; Young Adult

Animals ; Arteriosclerosis ; blood ; Blood Glucose ; metabolism ; Cholesterol ; blood ; Cholesterol, HDL ; blood ; Cholesterol, LDL ; blood ; Coronary Artery Disease ; blood ; Fatty Liver ; blood ; Humans ; Triglycerides ; blood

Resistin, a newly discovered peptide hormone mainly secreted by adipose tissues, is present at high levels in serum of obese mice and may be a potential link between obesity and insulin resistance in rodents. However, some studies of rat and mouse models have associated insulin resistance and obesity with decreased resistin expression. In humans, no relationship between resistin level and insulin resistance or adiposity was observed. This suggests that additional studies are necessary to determine the specific role of resistin in the regulation of energy metabolism and adipogenesis. In the present study, we investigated the effect of resistin in vivo on glucose and lipid metabolism by over-expressing resistin in mice by intramuscular injection of a recombinant eukaryotic expression vector pcDNA3.1-Retn encoding porcine resistin gene. After injection, serum resistin and serum glucose (GLU) levels were significantly increased in the pcDNA3.1-Retn-treated mice; there was an obvious difference in total cholesterol (TC) level between the experiment and the control groups on Day 30. In pcDNA3.1-Retn-treated mice, both free fatty acid (FFA) and high density lipoprotein (HDL) cholesterol levels were markedly lower than those of control, whereas HDL cholesterol and triglyceride (TG) levels did not differ between the two groups. Furthermore, lipase activity was expressly lower on Day 20. Our data suggest that resistin over-expressed in mice might be responsible for insulin resistance and parameters related to glucose and lipid metabolism were changed accordingly.
Animals ; Blood Glucose ; analysis ; Cholesterol, HDL ; blood ; Cholesterol, LDL ; blood ; Fatty Acids, Nonesterified ; blood ; Glucose ; metabolism ; HeLa Cells ; Humans ; Lipid Metabolism ; Male ; Mice ; Resistin ; blood ; physiology ; Triglycerides ; blood

To identify target energy balance-related behaviors (ERBs), baseline data from 141 overweight or obese schoolchildren (aged 8-14 years old) was used to predict adiposity [body mass index (BMI) and fat percentage] one year later. The ERBs included a modified Dietary Approach to Stop Hypertension diet score (DASH score), leisure-time physical activity (PA, days/week), and leisure screen time (minutes/day). Several cardiometabolic variables were measured in the fasting state, including systolic blood pressure (SBP), diastolic blood pressure (DBP), blood glucose (GLU), total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-C), and high-density lipoprotein (HDL-C). BMI and fat percentage were measured using a BIA body composition analyzer (MC-980MA, TANITA, Tanita Co., Guangzhou, China). Partial correlation coefficients (partial r) and multiple linear regression models were used to predict BMI and fat percentage one year later. Our sample consisted of 114 boys and 83 girls with a mean BMI of 24.7±3.7 kg/m2 and fat percentage of 34.2%±8.3% at baseline. BMI, fat percentage, and certain cardiometabolic variables were negatively associated with DASH score and leisure-time PA (all P<0.05), but positively associated with leisure screen time (all P<0.05) at baseline. Statistically significant predictors of BMI and fat percentage one year later were baseline BMI (partial r=0.85), fat percentage (partial r=0.69), eating out (times/week, partial r=0.18), and DASH Score (partial r=-0.18). Overall, childhood obesity prevention interventions should target reductions in ERBs.
Adiposity ; Adolescent ; Blood Glucose ; metabolism ; Blood Pressure ; Child ; Cholesterol ; blood ; Feeding Behavior ; Female ; Humans ; Male ; Obesity ; metabolism ; physiopathology ; psychology ; Overweight ; metabolism ; physiopathology ; psychology ; Triglycerides ; blood

OBJECTIVETo study the effect of liposuction on insulin resistance and lipid metabolism.

METHODSThe levels of serum triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and insulin sensitivity were measured pre-and 2-4 months postoperatively in 20 consecutive patients undergoing liposuction.

RESULTSCompared with preoperative, the insulin sensitivity increased significantly, the levels of TC and LDL-C decreased after the liposuction procedure.

CONCLUSIONSLiposuction may improve the insulin resistance and lipid metabolism.

Adult ; Blood Glucose ; metabolism ; Cholesterol ; blood ; Cholesterol, HDL ; blood ; Cholesterol, LDL ; blood ; Female ; Humans ; Insulin Resistance ; Lipectomy ; Lipid Metabolism ; Middle Aged ; Triglycerides ; blood ; Young Adult

This study was aimed to examine the effect of ovariectomy on visceral fat, serum adiponectin levels and lipid profile. Forty-five female Sprague Dawley rats were divided into three groups (n=15 each): ovariectomized group (OVX), ovariectomized plus estrogen-treated group (OVX+E2), and sham-operated group (SHAM). Body weight, abdominal adipose tissues, serum adiponectin and lipid profile were measured and compared among the groups after three-month feeding post-surgery. Significant increases in body weight and visceral fat were found in ovariectomized rats when compared with sham-operated ones and significant increases were also observed in serum adiponectin, triglyceride and very low density lipoprotein cholesterol levels in ovariectomized rats. Body weight, visceral fat and serum adiponectin levels were profoundly reduced in OVX+E2 group as compared with OVX group. It was concluded that ovarian hormone deficiency induced by ovariectomy leads to significant increases in body weight and visceral fat, along with increased serum adiponectin, triglyceride and very low density lipoprotein cholesterol levels in rats. Attenuation in these changes can be achieved by estrogen supplementation.
Adiponectin ; blood ; Animals ; Cholesterol, LDL ; blood ; Female ; Intra-Abdominal Fat ; metabolism ; Ovariectomy ; Rats ; Rats, Sprague-Dawley ; Triglycerides ; blood