Mebendazole was tested for its efficacy in individual treatment and mass control of Trichuris trichiura infection in Korea. The results were as follows: The efficacy of mebendazole in 430 cases 3 weeks after treatment with mebendazole(100-1,200 mg) was not so satisfactory (15.0-64.0 and 24.6-95.2% in cure and egg reduction rates respectively). But it was observed that the higher the total dose of the drug the better the efficacy. The egg positive rate of the inhabitants in mass control programme by 600 mg mebendazole decreased form 40.0 to 5.6 % during one year, May 1982-May 1983, by repeated blanket mass chemotherapy every 3 months (in conventional regimen), while the decrease was less marked or unrecognizable in 3-month (signle or two divided doses), 6-month, 12-month interval and placebo control groups. From the results, it was concluded that, although mebendazole was not highly effective in individual treatment of T. trichiura infection, it was fairly useful in mass cotrol, by repeated mass chemotherapy every 3 months.
parasitology-helmith-nematoda ; trichuriasis ; Trichuris trichiura ; chemotherapy-mebendazole ; mebendazol

The high incidence of intestinal parasites among the Korean people almost same as 40 years ago might be partly interpreted by the fact that they are all fond of raw vegetables cultivated on the farms fertilized with non-treated night soil. The cabbages, onions and radishes were collected from the five areas of Seoul vicinity and the number of parasites attached to those vegetables were investigated to compare with the results obtained 10 years ago by the same methods of sampling and examination as the present survey. The resultant findings were summarized as follows: The eggs of Ascaris, hookworm, Trichostrongylus and whipworm, rhabditoid larvae and filariform larvae of hookworms were detected from those vegetables. Additionally, a number of larvae of free living nematodes and morphologically undetermined eggs were also observed. The maximum number of parasites found from one vegetable were as follows: 16 Ascaris eggs on a cabbage, 27 hookworm eggs on an onion, 8 whipworm eggs on a cabbage, 68 filariform larvae of hookworm on an onion. The onions were highly contaminated by the number of parasites as much as 177.6 including the larvae of free living nematodes, the next being the cabbages with 25.3 and the radishes with 4.1 in average. No notable relationship was observed between the size of vegetables and the number of parasites attached to them. Ascaris eggs were found from 56 percent of all cabbages, 28 percent of the onions and 40 percent of the radishes; whipworm eggs were detected on 40 percent of radishes and the filariform larvae of hookworms were observed from 40 percent of onions examined. It may be concluded that there is no notable change in the number of parasites attached to the vegetables collected from the Seoul vicinity compared to the results investigated by the same method 10 years ago.
parasitology-helminth-nematoda-Ascaris ; hookworm ; Trichuris trichiura ; epidemiology ; vegetable

Usually egg count technique has been employed to know the intensity of infestation of human intestinal helminths and to elucidate the effects of anthelmintics. Comparing the three egg count methods - Stoll's egg dilution method, Beaver's direct smear method and FHK counting board method - the authors reached the following results: As the result of application of the three methods to 75 Ascaris egg positives and 95 Trichocephalus egg positives, in the case of Ascaris eggs, the egg detection rate was 99 per cent by Stoll's method, 97 per cent by Beaver's method and was lowest by FHK method at 79 percent. Meanwhile, in Trichocephalus eggs, Stoll's method revealed 92 percent, Beaver's method 95 percent, and FHK method 95 percent, there being no noticeable differences. With regard to EPG, in counting Ascaris eggs, Stoll's method showed a value closest to the actual number of eggs, and the value revealed by FHK method was smaller than the actual number. As the result of comparing the coefficiencies of variation of the three egg counting methods, both in Ascaris eggs and Trichocephalus eggs, the FHK method showed the smallest, followed by Stoll's method and Beaver's method.
parasitology-helminth-nematoda ; Ascaris lumbricoides ; Trichuris trichiura ; diagnosis

A parasitic survey on vegetables collected from markets and vegetable gardens in Taegu area was conducted for the discovery of human parasitic eggs and larvae. Three species of vegetable, lettuce (Lactuca sativa), young radish(Raphanus sapivus) and Chinese cabbage (Brassica pekinensis) were selected. All vegetable leaves were washed with a hard brush, and then species of parasites and the approximate mean number of parasitic eggs per 200 grams of vegetable leaves were investigated. When vegetables collected from markets were examined, 5 species of parasite eggs (ascarid, trichurid, Trichostrongylus, Clonorchis and hookworms) and 2 larvae (filariform and rhabditoid ) were found. Furthermore, a number of eggs and larvae of undetermined species were also observed. Of the parasites studied, ascarid egg was found to be highest (49.0%), followed Trichostrongylus egg(18.0%) as well as filariform larva of hookworms (19.7%), and the least often observed was rhabditoid larva of hookworms(0.7%). The recovery rate of parasites among lettuce, young radish and Chinese cabbage collected from markets ranged from 23.2 to 91.9 percent and was similar to that from vegetable gardens, where Chinese cabbage showed the highest (91.1%) and lettuce being next(49.0%) in positivity of ascarid eggs. In the case of filariform larva, the rate of Chinese cabbage was twice as high as that of lettuce and young radish. There was a significant reduction in the rate of filariform larva, suggesting that a single washing of vegetables at the vegetable washing stand would reduce the number of parasites attached to vegetable leaves, when young radish washed at the stand was compared with that unwashed. In the monthly rate of parasites recovered from young radish, there was significant fluctuations between the eggs and filariform larva of hookworms. The mean number of ascarid egg per 200 grams of vegetable was 7.5 in young radishes, 3.1 in lettuces, and 0.5 in Chinese cabbages, in decreasing order. It is noteworthy that young radish contained more than 10 times more than Chinese cabbage. These results would seem to indicate that one of the important routes of infection is due to consumption of pickled young radishes in summer than pickled Chinese cabbages in winter.
parasitology-nematoda-trematoda ; Ascaris lumbricoides ; Trichuris trichiura ; Trichostrongylus orientalis ; Clonorchis sinensis ; hookworm ; epidemiology

A total of 48 subjects harbouring Trichuris trichiura, Ascaris lumbricoides, hookworm and/or Enterobius vermicularis were treated with oxantel/pyrantel pamoate tablets (100 mg of each) in a single dose of 20 mg base per kg of body weight. In all 37 cases of A. lumbricoides and 8 cases of A. duodenale infections cured completely, and the mean recovered worm-load was 3.8 with a range of 1-21 and 5.8 with a range of 3-9 respectively. In T. trichiura infection, 32(71.1%) of 45 cases cured completely and the average egg reduction rate was 90.8 per cent. The mean recovered worm-load was 14.6 with a rnage of 1-77 worms. On the other hand, in E. vermicularis infection, 37 (84.1 %) of 44 patients were negative eggs by anal swab tests on the 10 to 11th days and 27 (61.4%) on the 20 to 21st days after treatment. The mean recovered worm-load was 17.7 with a range of 1-62. Only one patient with Trichostrongylus orientalis treated with this drug showed no eggs in his stools throughout the post-treatment examinations. Side effects were not noted in all treated cases. These findings demonstrate that a single dose of oxantel/pyrantel pamoate tablets can be considered a drug of choice for multiple infections with these nematodes.
parasitology-helminth-nematoda ; Trichuris trichiura ; Ascaris lumbricoides ; hookworm ; Enterobius vermicularis ; chemotherapy ; oxantel/pyrantel pamoate

The efficacy of the cellophane thick smear(CTS) technique was reassessed for detecting helminths eggs such as Ascaris lumbricoides, Trichuris trichiura and Clonorchis sinensis, in comparsion with the formalin-ether(F-E) one, with repeated smears per case. From the fecal samples of 411 ROK Army soldiers, a total of 3,288 smears were made and examined; 4 by CTS and 4 by F-E techniques. The expected egg detectability with one, two, three or four smears by each technique was mathemativally calculated. The results were as follows: When the results of all 8 smears per case were integrated, the number of cases eith Ascaris egg were 54(13.1%), Trichuris 125(30.4%) and Clonorchis 33(8.0%). Some other kinds of helminths eggs and protozoan cysts were found from a few cases each. The calculated detectability of Ascaris eggs by CTS technique was fairly high(95.8 - 96.3%) with 1-4 smears, while that by F-E technique was not so high(73.1 - 88.9%). In case of Trchuris eggs, the egg detectability by CTS technique with 1-4 smears was a little lower(62.2-86.4%) than that by F-E technique(73.4 - 91.2%). The detectability of Clonorchis eggs with 1-4 smears by CTS technique was the lowest(44.7 - 60.6%) among the three helminths as well as much lower than that by F-E technique(67.4 - 87.9%).
parasitology-helminth-trematoda-nemaoda ; Ascaris lumbricoides ; Trichuris trichiura ; Clonorchis sinensis ; diagnosis ; formalin ; ether

Present trial was carried out to evaluate the anthelmintic efficacy of oxantel/pyrantel tablets against intestinal nematode infections, and to determine the efficacy of oxantel tablels against Trichuris infection. A total of 34 subjects with the mixed infections were treated with oxantel/pyrantel tablets (100 mg/tablet each) in a single dose of 15 mg/kg body weight, and another group of 22 Trichuris infected cases received oxantel pamoate tablets (125 mg/tablet) in a single dose of 15 mg/kg. All stool examinations were done before the treatment and 3 weeks after the treatment. The cellophane thick smear (Kato's technique) and Stoll's dilution egg counting method were employed. The results of the trial were summarized as follows: The cure rates (egg negative conversion rates) and egg reduction rates for oxantel/pyrantel tablets were 85.3 percent and 97 percent in trichuriasis, 100 percent each in ascariasis and ancylostomiasis. The oxantel tablet treated group demonstrated a cure rate of 90.9 percent and an egg reduction rate of 96.3 percent in the treatment of Trichuris. There were no detectable objective and subjective side effects in this trial. Both oxantel/pyrantel and oxantel pamoate tablets were readily accepted and well tolerated.
parasitology-helminth-nematoda ; Enterobius vermicularis ; Ancylostoma duodenale ; Trichuris trichiura ; chemotherapy-oxantel/pyrante ; oxantel pamoate

The present study was undertaken to evaluate the anthelmintic effects of fenbendazole against intestinal nematode; Ascaris lumbricoides, hookworm and Trichuris trichiura, and to compare the efficacy in fenbendazole, oxantel-pyrantel pamoate and placebo by means of double blind method. Out of 114 subjects harbouring Ascaris lumbricoides, hookworm and Trichuris trichiura, 36 cases were treated with single dose of fenbendazole, 38 cases with oxantel-pyrantel pamoate, and the remaining 40 cases had received the placebo. The results were as follows: In the group treated with fenbendazole (30-50 mg/kg), the cure rates were 83.9 percent in 31 subjects with Ascaris lumbricoides and 83.3 percent in 18 subjects with hookworm, and only 28.6 percent in 28 subjects with T. trichiura respectively. In the group treated with a single dose of oxantel-pyrantel pamoate (10 mg/mg), the cure rates were 96.7 percent in 30 subjects with A. lumbricoides, 95.2 percent in 21 subjects with hookworm, and 54.6 percent in 33 subjects with T. trichiura. Egg reduction rate was 85.7 percent in T. trichiura cases. On the other hand, the egg negative conversion rates in placebo group were 9.7, 8.3 and 33.3 percent in Ascaris, Trichuris and hookworm infections respectively. The above results showed that fenbendazole was highly effective against Ascaris and hookworm. However, incomparisom with oxantel-pyrantel pamoate, fenbendazole was less effective in regards of A. lumbricoides, hookworm and T. trichiura infections.
parasitology-helminth-nematoda ; chemotherapy ; Ascaris lumbricoides ; hookworm ; Trichuris trichiura ; fenbendazole ; oxantel-pyrantel pamoate

A total of 56 subjects with multiple nematode infections with T. trichiura, Ascaris, hookworms and Enterobius were treated with oxantel and pyrantel pamoate mixture in a paratable suspension(50 mg of each per ml). A single dose of 10 mg per kg body weight in each cured 100 per cent of 54 subjects with Ascaris, 97.1 per cent of 35 subjects with hookworms, 77.8 per cent of 36 with Enterobius and 73.2 per cent of 56 subjects with T. trichiura infestation. The mean egg per gram stool reduction rate in T. trichiura infection was 91.9%. Of the 31 subjects infected with Ancylostoma doudenale 96.8% were cured with a single dose and 4 infected with Necator americanus showed a 100% cure rate with a similar daily dose on 3 consecutive days. Side effects were few and mild. There was no clinical or laboratory evidence of drug toxicity. These findings show a single dose of oxantel and pyrantel pamoate mixture to be a highly effective and acceptable treatment for multiple infections with these nematodes.
parasitology-helminth-nematoda ; Trichuris trichiura ; Ascaris lumbricoides ; hookworm ; Enterobius vermicularis ; chemotherapy-oxantel pamoate-pyrantel pamoate

This study was undertaken to find out the possibility of iron-deficiency anemia by the intestinal blood loss in massive infection cases of T. trichiurus. Among the children of a community in which the whipworm infections were highly prevalent, 7 cases were selected whose E.P.G. of whipworm ova were more than 1,000. The hematological findings and estimated blood loss using (51)Cr were undertaken. The results could be summarized as follows: The E.P.G. and E.P.D. of T. trichiurus ova in studied 7 cases were 10,500-37,200/gm of feces and 0.90-5.14 million/day respectively. Findings of hematological examination were in lower limit of normal in hemoglobin content and hematocrit. And erythrocytes were neither microcytic nor hypochromic. Differential count of leucocytes showed persistently low grade of eosinophilia. Serum iron content measured by modification of Barkan method showed subnormal value in 5 out of 7 cases. Erythrocyte radioactivity half disappearance time(T1/2) and intestinal blood loss were estimated using (51)Cr-tagging erythrocytes. And the results showed that T1/2 were shortened (13-19 days ) in all cases and the blood loss was 0.94-6.54 ml/day which were correlated with worm burden (E.P.D.) significantly. From the above results, it could be concluded that intestinal blood loss of T. trichiurus heavy infection were actually occurred but the amount of losses were easily compensated.
parasitology-helminth-nematoda ; Trichocephalus trichiurus ; Trichuris trichiura ; anemia ; intestine ; hematology ; Cr(51)