1.New antiepileptic drugs. II. Clinical use.
Journal of Korean Medical Science 1996;11(4):289-304
No abstract available.
Acetic Acids/adverse effects/pharmacology
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Anticonvulsants/adverse effects/*pharmacology
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Carbamazepine/adverse effects/analogs & derivatives/pharmacology
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Clinical Trials
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Forecasting
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Fructose/adverse effects/analogs & derivatives/pharmacology
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Human
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Isoxazoles/adverse effects/pharmacology
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Propylene Glycols/adverse effects/pharmacology
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Triazines/adverse effects/pharmacology
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Vigabatrin
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gamma-Aminobutyric Acid/adverse effects/analogs & derivatives/pharmacology
2.Lamotrigine in pregnancy: safety profile and the risk of malformations.
Prakash ; L V PRABHU ; M A NASAR ; R RAI ; S MADHYASTHA ; G SINGH
Singapore medical journal 2007;48(10):880-883
The use of antiepileptic drugs in pregnancy always presents challenges to doctors and their patients as it may have deleterious effects on the developing embryo. Lamotrigine is most commonly-prescribed drug among the newer antiepileptic drugs; hence, it has been selected for the present review. A number of studies pertaining to the safety of lamotrigine use during pregnancy have been reported, with differing results. Contradictory results have been reported in animals regarding lamotrigine teratogenicity, and human studies have also proven inconclusive. In many countries, human pregnancy registries are maintained to establish the safety of antiepileptic drugs during pregnancy, as all the different suggestions favour some over others, with specific antiepileptic combinations still being questioned. It is our hope that the present work may integrate the available disparate relevant facts into a directed effort towards minimising the risk of foetal compromise.
Abnormalities, Drug-Induced
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Animals
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Anticonvulsants
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adverse effects
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therapeutic use
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Epilepsy
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drug therapy
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Female
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Folic Acid Deficiency
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chemically induced
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Humans
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Pregnancy
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Teratogens
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pharmacokinetics
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pharmacology
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Triazines
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adverse effects
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therapeutic use
3.HLA Allele Frequencies in 5802 Koreans: Varied Allele Types Associated with SJS/TEN According to Culprit Drugs.
Hye Jung PARK ; Young Joo KIM ; Dong Hyun KIM ; Junho KIM ; Kyung Hee PARK ; Jung Won PARK ; Jae Hyun LEE
Yonsei Medical Journal 2016;57(1):118-126
PURPOSE: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are very serious forms of drug-induced cutaneous adverse reaction. SJS/TEN induced by certain drug is well known to be associated with some human leukocyte antigen (HLA) gene type. We aimed to explore HLA allele frequencies and their association with SJS/TEN according to culprit drugs in Korea. MATERIALS AND METHODS: We enrolled 5802 subjects who had results of HLA typing test from August 2005 to July 2014. Total 28 SJS/TEN patients were categorized based on culprit drugs (allopurinol, lamotrigine, carbamazepine) and identified the presence of HLA-B*58:01, HLA-B*44:03, HLA-B*15:02, and HLA-A*31:01. RESULTS: HLA-A*24:02 (20.5%), HLA-B*44:03 (10.0%), and HLA-Cw*01:02 (17.1%) were the most frequent type in HLA-A, -B, and -C genes, respectively. Allele frequencies of HLA-B*58:01, HLA-B*44:03, HLA-A*31:01, and HLA-B*15:02 were 7.0%, 10.0%, 5.0%, and 0.3%, respectively. In 958 allopurinol users, 9 subjects (0.9%) were diagnosed with SJS/TEN. Among them, 8 subjects possessed HLA-B*58:01 allele. SJS/TEN induced by allopurinol was more frequently developed in subjects with HLA-B*58:01 than in subjects without it [odds ratio: 57.4; confidence interval (CI) 7.12-463.50; p<0.001]. Allopurinol treatment, based on screening by HLA-B*58:01 genotyping, could be more cost-effective than that not based on screening. HLA-B*44:03 may be associated with lamotrigine-induced SJS/TEN (odds ratio: 12.75; CI 1.03-157.14; p=0.053). Among carbamazepine users, only two patients experienced SJS/TEN and possessed neither HLA-B*15:02 nor HLA-A*31:03. CONCLUSION: HLA gene frequencies varied in Korea. Screening of HLA-B*58:01 before the use of allopurinol might be needed to anticipate probability of SJS/TEN.
Adult
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Aged
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*Alleles
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Allopurinol/adverse effects/*pharmacology
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Anticonvulsants/*adverse effects
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Asian Continental Ancestry Group/*genetics
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Carbamazepine/adverse effects/*pharmacology
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Case-Control Studies
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Drug-Related Side Effects and Adverse Reactions/*genetics/immunology
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Female
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Gene Frequency
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Genetic Predisposition to Disease
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Genotype
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HLA-B Antigens/*genetics
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Humans
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Male
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Middle Aged
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Odds Ratio
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Polymorphism, Single Nucleotide
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Republic of Korea
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Retrospective Studies
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Risk Factors
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Stevens-Johnson Syndrome/ethnology/etiology/*genetics
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Triazines/adverse effects/*pharmacology