1.Simultaneous dosage of loratadine and pseudoephedrine sulfate in manufactured tablets by derivative ultra-violet spectrography
Pharmaceutical Journal 2003;322(2):28-30
A new spectrophotometry was described for the simultaneous analysis of pseudoephedrine sulfate-Ioratadine combination. The derivative spectrophotometry dA/d values were read at zero-crossing point. Mean recoveries were found to be more than 98% for these compound in mixture. The procedure does not require any separation step and proven to be rapid, simple and accurate for determination of the mentioned sample or corresponding multi-component mixture
Spectrophotometry
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Ultraviolet Therapy
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Loratadine
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tablets
2.Exploration of the effects an artemisinine suspension by subcutaneous injection in white mice infected with Plasmodium berghei
Pharmaceutical Journal 1999;282(10):14-16
Artemisinine was prepared into a suspension suitable for subcutaneous administration in Plasmodium berghei- infected mice. This formulation (20mg/kg b.i.d, total dosage of 200mg/kg) was compared to oral artemisinine (at the same dose) in 50 Plasmodium berghei infected mice. The study also included a non treated control group and a placebo suspension group. The drug was applied for 5 days, beginning at 4 hours after infection. All mice treated by subcutaneous application were alive and did not show any toxicity or side effects due artemisinine. There was no recrudescence during 60 days of follow-up. All mice in the control, placebo and oral artemisinin group died with hyperparasitemia. The result showed that subcutaneous formulation of artemisinin is more effective than oral ones at the same dose.
Artemisinine
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Plasmodium berghei
3.Sleep Quality and Poor Sleep-related Factors Among Healthcare Workers During the COVID-19 Pandemic in Vietnam
Thang PHAN ; Ha Phan Ai NGUYEN ; Cao Khoa DANG ; Minh Tri PHAN ; Vu Thanh NGUYEN ; Van Tuan LE ; Binh Thang TRAN ; Chinh Van DANG ; Tinh Huu HO ; Minh Tu NGUYEN ; Thang Van DINH ; Van Trong PHAN ; Binh Thai DANG ; Huynh Ho Ngoc QUYNH ; Minh Tran LE ; Nhan Phuc Thanh NGUYEN
Journal of Preventive Medicine and Public Health 2023;56(4):319-326
Objectives:
The coronavirus disease 2019 (COVID-19) pandemic has increased the workload of healthcare workers (HCWs), impacting their health. This study aimed to assess sleep quality using the Pittsburgh Sleep Quality Index (PSQI) and identify factors associated with poor sleep among HCWs in Vietnam during the COVID-19 pandemic.
Methods:
In this cross-sectional study, 1000 frontline HCWs were recruited from various healthcare facilities in Vietnam between October 2021 and November 2021. Data were collected using a 3-part self-administered questionnaire, which covered demographics, sleep quality, and factors related to poor sleep. Poor sleep quality was defined as a total PSQI score of 5 or higher.
Results:
Participants’ mean age was 33.20±6.81 years (range, 20.0-61.0), and 63.0% were women. The median work experience was 8.54±6.30 years. Approximately 6.3% had chronic comorbidities, such as hypertension and diabetes mellitus. About 59.5% were directly responsible for patient care and treatment, while 7.1% worked in tracing and sampling. A total of 73.8% reported poor sleep quality. Multivariate logistic regression revealed significant associations between poor sleep quality and the presence of chronic comorbidities (odds ratio [OR], 2.34; 95% confidence interval [CI], 1.17 to 5.24), being a frontline HCW directly involved in patient care and treatment (OR, 1.59; 95% CI, 1.16 to 2.16), increased working hours (OR, 1.84; 95% CI,1.37 to 2.48), and a higher frequency of encountering critically ill and dying patients (OR, 1.42; 95% CI, 1.03 to 1.95).
Conclusions
The high prevalence of poor sleep among HCWs in Vietnam during the COVID-19 pandemic was similar to that in other countries. Working conditions should be adjusted to improve sleep quality among this population.
4.Immunohistochemical expression in idiopathic inflammatory myopathies at a single center in Vietnam
Dat Quoc NGO ; Si Tri LE ; Khanh Hoang Phuong PHAN ; Thao Thi Phuong DOAN ; Linh Ngoc Khanh NGUYEN ; Minh Hoang DANG ; Thien Thanh LY ; Thu Dang Anh PHAN
Journal of Pathology and Translational Medicine 2024;58(4):174-181
Background:
The identification of idiopathic inflammatory myopathies (IIMs) requires a comprehensive analysis involving clinical manifestations and histological findings. This study aims to provide insights into the histopathological and immunohistochemical aspects of IIMs.
Methods:
This retrospective case series involved 56 patients diagnosed with IIMs at the Department of Pathology, University of Medicine and Pharmacy at Ho Chi Minh City, from 2019 to 2023. The histology and immunohistochemical expression of HLA-ABC, HLA-DR, C5b-9, Mx1/2/3, and p62 were detected.
Results:
We examined six categories of inflammatory myopathy, including immunemediated necrotizing myopathy (58.9%), dermatomyositis (DM; 23.2%), overlap myositis (8.9%), antisynthetase syndrome (5.4%), inclusion body myositis (IBM; 1.8%), and polymyositis (1.8%). The average age of the patients was 49.7 ± 16.1 years, with a female-to-male ratio of 3:1. Inflammatory cell infiltration in the endomysium was present in 62.5% of cases, perifascicular atrophy was found in 17.8%, and fiber necrosis was observed in 42 cases (75.0%). Rimmed vacuoles were present in 100% of cases in the IBM group. Immunohistochemistry showed the following positivity rates: HLA-ABC (89.2%), HLA-DR (19.6%), C5b-9 (57.1%), and Mx1/2/3 (10.7%). Mx1/2/3 expression was high in DM cases. p62 vacuole deposits were noted in the IBM case. The combination of membrane attack complex and major histocompatibility complex I helped detect IIMs in 96% of cases.
Conclusions
The diagnosis of IIMs and their subtypes should be based on clinical features and histopathological characteristics. Immunohistochemistry plays a crucial role in the diagnosis and differentiation of these subgroups.
5.Evaluation of erectile dysfunction in patients with lumbosacral disc herniation
Dinh Khanh LE ; Thanh Minh NGUYEN ; Thi Phuong Hoai DINH ; Ngoc Tri PHAM ; Nhat Minh NGUYEN
Hue Journal of Medicine and Pharmacy 2023;13(7):127-132
Objectives: Survey on erectile dysfunction in patients with lumbosacral disc herniation and evaluation of their clinical improvement after surgical treatment of spinal canal stenosis due to herniated disc. Materials and Methods: 35 patients with lumbosacral were treated with discectomy with posterior intervertebral fusion (PLIF) surgery from 10/2021 - 4/2022 at the Department of Neurology, Hue University of Medicine and Pharmacy Hospital. Patients were evaluated for erectile dysfunction and postoperative improvement using the IIEF-5, CSFQ-14, DASS-21, Oswestry scales. Results: The mean age was 48.49 ± 9.15 years old. 51.4% of patients had the most severe hernia at the L4-L5 disc, 28.6% L3-L4 and 20% L5-S1. 100% of patients with herniated disc have erectile dysfunction. Of which 40% had mild-moderate disorders, 34.3% had moderate disorders, 14.3% had severe disorders and 11.4% had mild disorders. The CSFQ-14 and DASS-21 scales were correlated with erectile dysfunction (p < 0.05). Surgery significantly improved pain (VAS score), activity limitation (ODI and JOA), degree of erectile dysfunction, changes in sexual function, depression and anxiety, stress of the patient 1 month after surgery (p < 0.05). Conclusions: Patients with lumbosacral disc herniation had a 100% erectile dysfunction rate with a mean IIEF-5 score of 11.69 ± 3.77. The CSFQ-14 and DASS-21 scores have a strong positive correlation with erectile dysfunction. Surgical treatment of spinal canal stenosis due to lumbosacral disc herniation improves the clinical status of herniated disc as well as improves erectile dysfunction in these patients.
6.Mental Health Among Healthcare Workers During the COVID-19 Pandemic in Vietnam
Nhan Phuc Thanh NGUYEN ; Ha Phan Ai NGUYEN ; Cao Khoa DANG ; Minh Tri PHAN ; Huynh Ho Ngoc QUYNH ; Van Tuan LE ; Chinh Van DANG ; Tinh Huu HO ; Van Trong PHAN ; Thang Van DINH ; Thang PHAN ; Thi Anh Thu DANG
Journal of Preventive Medicine and Public Health 2024;57(1):37-46
Objectives:
The objective of this study was to characterize mental health issues among Vietnamese healthcare workers (HCWs) and to identify related factors.
Methods:
A cross-sectional study was conducted with 990 HCWs in 2021. Their mental health status was measured using the Depression, Anxiety, and Stress Scale.
Results:
In total, 49.9%, 52.3%, and 29.8% of respondents were found to have depression, anxiety, and stress, respectively. The multivariable linear regression model revealed that factors associated with increased anxiety scores included depression scores (β, 0.45; 95% confidence interval [CI], 0.39 to 0.51) and stress scores (β, 0.46; 95% CI, 0.41 to 0.52). Factors associated with increased depression scores included being frontline HCWs (β, 0.57; 95% CI, 0.10 to 1.10), stress scores (β, 0.50; 95% CI, 0.45 to 0.56), and anxiety scores (β, 0.41; 95% CI, 0.36 to 0.47), while working experience was associated with reduced depression scores (β, -0.08; 95% CI, -0.16 to -0.01). Factors associated with increased stress scores included working experience (β, 0.08; 95% CI, 0.00 to 0.16), personal protective equipment interference with daily activities (β, 0.55; 95% CI, 0.07 to 1.00), depression scores (β, 0.54; 95% CI, 0.48 to 0.59), and anxiety scores (β, 0.45; 95% CI, 0.39 to 0.50), while age was associated with reduced stress scores (β, -0.12; 95% CI, -0.20 to -0.05).
Conclusions
Specific interventions are necessary to enhance and promote the mental health of HCWs so they can successfully cope with the circumstances of the pandemic.
7.Findings and lessons from establishing Zika virus surveillance in southern Viet Nam, 2016
Lan Trong Phan ; Quang Chan Luong ; Thi Hong Hien Do ; Cindy H Chiu ; Thang Minh Cao ; Thao Thi Thanh Nguyen ; Hai Thanh Diep ; Thao Phuong Huynh ; Dung Tri Nguyen ; Nga Hong Le ; Satoko Otsu ; Phu Dac Tran ; Thuong Vu Nguyen ; Masaya Kato
Western Pacific Surveillance and Response 2019;10(2):22-30
Objective:
To document the evolution and optimization of the Zika virus (ZIKV) disease surveillance system in southern Viet Nam in 2016 and to describe the characteristics of the identified ZIKV-positive cases.
Methods:
We established a sentinel surveillance system to monitor ZIKV transmission in eight sites in eight provinces and expanded the system to 71 sites in 20 provinces in southern Viet Nam in 2016. Blood and urine samples from patients who met the case definition at the sentinel sites were tested for ZIKV using real-time reverse transcription polymerase chain reaction at the Pasteur Institute in Ho Chi Minh City (PI-HCMC). We conducted descriptive analysis and mapped the ZIKV-positive cases.
Results:
In 2016, 2190 specimens from 20 provinces in southern Viet Nam were tested for ZIKV at PI-HCMC; 626 (28.6%), 484 (22.1%), 35 (1.6%) and 1045 (47.7%) tests were conducted in the first, second, third and fourth quarters of the year, respectively. Of these tested specimens, 214 (9.8%) were ZIKV positive with 212 (99.1%) identified in the fourth quarter. In the fourth quarter, the highest positivity rate was those in age groups 30–39 years (30.0%) and 40–59 years (31.6%). Of the 214 ZIKV-positive patients, 210 (98.1%) presented with rash, 194 (90.7%) with fever, 149 (69.6%) with muscle pain, 123 (57.5%) with joint pain and 66 (30.8%) with conjunctivitis.
Discussion
The surveillance system for ZIKV disease underwent several phases of optimization in 2016, guided by the most up-to-date local data. Here we demonstrate an adaptable surveillance system that detected ZIKV-positive cases in southern Viet Nam.
8.Study on prognostic index for survival m-LCPI in patients with primary non-small cell lung cancer
Thi Mai Thanh HOANG ; Xuan Thuy Anh HA ; Van Khanh DANG ; Minh Tri PHAN ; Thi Xinh Tuoi TRAN ; Ngoc Quynh Huong LE ; Thi Huong Mo NGUYEN ; Nguyen Ha Trang TRAN
Hue Journal of Medicine and Pharmacy 2023;13(7):133-139
Background: Lung cancer is a common cancer with a high mortality rate. The identification of prognostic factors in lung cancer patients in Vietnam is still limited and inconsistent in clinical practice. Objectives: To describe the clinical, paraclinical characteristics and m-LCPI index in patients with primary non-small cell lung cancer and evaluate the factors affecting overall survival in patients with primary non-small cell lung cancer. Methods: Prospective study of 210 cases of non-small cell lung cancer diagnosed with primary non-small cell lung cancer at the Oncology Department of Hue University of Medicine and Pharmacy Hospital and Hue Central Hospital from February 2020 to February 2023. Results: The majority of hospitalizations were at late stages, from stage IIIA (89%), group 3 and 4 in m-LCPI grading scale constituted the majority (80%). Average overall survival at 3 years was 20.0 ± 14 months, and gradually decreased to 54.8%, 40%, and 38.6% after 1 year, 2 years and 3 years, respectively. Regression analysis of COX model between m-LCPI and OS showed statistical significance with m-LCPI 4 (HR = 3.9, 95%CI = 1.57 - 9.69, p = 0.003), while m-LCPI 3 (HR = 2.44, 95% CI 0.97 - 6.13), p = 0.058) had a weak correlation. Conclusion: Our study shows that 38.6% of patients were still alive after 3 years of diagnosis. m-LCPI index is a good predictor of the patients’ overall survival.
9.Blood pressure screening results in adults in Thua Thien Hue province through the program “May Measurement Month” 2022 of the International Society of Hypertension
Manh Tri NGO ; Thi Hoai Thuong TRAN ; Thanh Thien LE ; Tan Hung HUYNH ; Anh Tuyet NGUYEN ; Thi Khanh Van NGUYEN ; Thi Minh Luong TRAN ; Anh Tien HOANG ; Van Minh HUYNH
Hue Journal of Medicine and Pharmacy 2023;13(7):15-22
Background: Hypertension is a common disease in adults, also the leading cause of cardiovascular disease and premature death worldwide. The prevalence of hypertension has increased, especially in low- and middle-income countries. Therefore, hypertension screening is important to provide the basis and evidence for the development of timely intervention policies and programs. The objective of the “May Measurement Month” 2022 program is to investigate the prevalence of hypertension, drug treatment and blood pressure control in people in Thua Thien Hue province and to assess the risk factors surrounding hypertension. Subjects and Methods: This cross–sectional study collected data from volunteer adults (≥ 18 years old) in Thua Thien Hue province from 7/2022 to 8/2022. Sitting blood pressure had been measured in triplicate according to standardized specified methods of the International Society of Hypertension. Results: Average age 54.07 ± 18.17, there were 627 people (23.4%) with hypertension at the time of screening, 245 of which (39.1%) had never been diagnosed with hypertension before screening at the time. 724 people were on treatment with 1 or more types of drug, however, there were 337 people (46.5%) having their blood pressure not controlled. The statistics showed that 84.9% of volunteers were using at least 1 drug to treat hypertension. Related factors of hypertension are age, sex, overweight/obesity status, smoking, medical history of diabetes and medical history of COVID-19. The rate of subjects who had history of COVID-19 was 36.4%, including 31.6% of hypertension patients. Conclusion: The hypertension percentage of Thua Thien Hue population is still high and the rate of blood pressure control is still limited. There is a relationship between hypertension proportion and history of COVID-19. It is necessary to publish timely intervention measures to reduce the rate of hypertension and its risks to people.