1.Role of B-cell-activating-factor in immune regulation--review.
Jian-Fang DU ; Jia-Xi WANG ; Dong-Gang XU
Journal of Experimental Hematology 2006;14(3):631-634
B cell activating factor (BAFF) is one of the TNF family member, regulates the survival and maturation of B lymphocyte. BAFF binds to three receptors: BCMA, TACI and BAFF-R. In recent years, studies have revealed important roles of BAFF and its receptors in immune regulation of antibody isotype switching, germinal center maintenance, and T cell co-stimulation, that may provide new drugs in the future for the treatment of autoimmune disorders, lymphoma and B cell immunodeficiencies. Therefore, the structure, expression, receptors, biological function and clinical application of BAFF are briefly summarized in this review.
B-Cell Activating Factor
;
immunology
;
B-Cell Activation Factor Receptor
;
immunology
;
B-Cell Maturation Antigen
;
immunology
;
B-Lymphocytes
;
immunology
;
Humans
;
Immunity
;
Transmembrane Activator and CAML Interactor Protein
;
immunology
2.Progress in the study of BLyS and APRIL on regulating T cell responses in rheumatoid arthritis.
Acta Pharmaceutica Sinica 2013;48(7):979-985
B lymphocyte stimulator (BLyS), a tumor neurosis factor ligand superfamily, is an important factor of B cell survival and activation. However, BLyS also regulates T cell activation and survival, playing key roles in T cell-mediated autoimmune disorders. In the paper, we introduced the mechanisms of BLyS and a proliferation-inducing ligand (APRIL) regulating T cell responses and their roles in rheumatoid arthritis (RA).
Animals
;
Antibodies, Monoclonal, Humanized
;
therapeutic use
;
Arthritis, Rheumatoid
;
drug therapy
;
metabolism
;
pathology
;
B-Cell Activating Factor
;
metabolism
;
B-Cell Activation Factor Receptor
;
metabolism
;
B-Cell Maturation Antigen
;
metabolism
;
B-Lymphocytes
;
metabolism
;
pathology
;
Humans
;
Lymphocyte Activation
;
Recombinant Fusion Proteins
;
therapeutic use
;
T-Lymphocytes
;
metabolism
;
pathology
;
Transmembrane Activator and CAML Interactor Protein
;
metabolism
;
Tumor Necrosis Factor Ligand Superfamily Member 13
;
metabolism
3.TACI:Fc scavenging B cell activating factor (BAFF) alleviates ovalbumin-induced bronchial asthma in mice.
Experimental & Molecular Medicine 2007;39(3):343-352
Asthma was induced by the sensitization and challenge with ovalbumin (OVA) in mice. B-cell activating factor (BAFF) plays a role in mature B cell generation and maintenance. Here, we investigated whether, BAFF expression was changed in OVA-induced mice and whether the control of BAFF expression level alleviates the symptom of bronchial asthma. BAFF expression was detected in alveolar-associated cells surrounding bronchi of OVA-induced mouse lung tissues. BAFF protein was also increased in OVA-induced mouse serum. The increased BAFF transcripts was detected in OVA-induced mouse splenocytes. OVA-induced asthma was associated with the increased number of eosinophils in bronchoalveolar lavage fluid (BALF). When TACI:Fc scavenging soluble BAFF was injected to OVA-induced mice, a significant inhibition was detected in the thickness of airway smooth muscle and glycol-containing cellular elements in airway that were visualized by hematoxylin/eosin Y and periodic acid-Schiff staining, respectively. In addition, when mice were treated with TACI:Fc protein, BAFF protein level was decreased in alveolar-associated cells surrounding bronchi of OVA-induced mouse lung tissues compared to control mice. When compared to OVA-induced control, TACI:Fc treatment reduced the percentage of non-lymphoid cells and no changes were detected in lymphoid cell population. Hypodiploid cell formation in BALF was decreased by OVA-challenge but it was recovered by TACI:Fc treatment. Collectively, data suggest that asthmatic symptom could be alleviated by scavenging BAFF and then BAFF could be a novel target for the develpoment of anti-asthmatic agents.
Animals
;
Apoptosis
;
Asthma/chemically induced/*drug therapy/immunology
;
B-Cell Activating Factor/*biosynthesis
;
Bronchi/metabolism/pathology
;
Bronchoalveolar Lavage Fluid/cytology
;
Eosinophils/pathology
;
Female
;
Humans
;
Immunoglobulin Fc Fragments/*genetics
;
Immunoglobulin G/*genetics
;
Lymphocytes/pathology
;
Mice
;
Mice, Inbred BALB C
;
*Ovalbumin
;
Pulmonary Alveoli/metabolism
;
Recombinant Fusion Proteins/genetics/*therapeutic use
;
Spleen/metabolism
;
Transmembrane Activator and CAML Interactor Protein/*genetics