1.The effects of preservation of periosteum and medullary cavity and infiltration of transforming growth factor in distraction osteogenesis(in rabbits).
Kwang Jin RHEE ; Hyong Sik MIN ; Chan Hee PARK ; Jun Young YANG
The Journal of the Korean Orthopaedic Association 1993;28(5):1826-1835
No abstract available.
Periosteum*
;
Transforming Growth Factors*
2.Role of Transforming Growth Factor Alpha in Hepatocarcinogenesis.
The Korean Journal of Hepatology 2000;6(1):6-11
No abstract available.
Transforming Growth Factor alpha*
;
Transforming Growth Factors*
3.Expressions of transforming growth factor beta in patients with rheumatioid arthritis and osteoarthritis.
Chae Gi KIM ; Wern Chan YOON ; Yong Ho SONG ; Sang Gyung KIM ; Jung Yoon CHOE
Immune Network 2001;1(3):244-249
No abstract available.
Arthritis*
;
Osteoarthritis*
;
Transforming Growth Factor beta*
;
Transforming Growth Factors*
4.Transforming growth factor (TGF)-beta1 conjugated chitosan film for enhanced osteoblastic activity.
Yoon Jeong PARK ; Jue Yeon LEE ; Kyung Hwa KIM ; Tae Il KIM ; Myung Hee LEE ; Seung Yoon SHIN ; Yang Jo SEOL ; Yong Moo LEE ; In Chul RHYU ; Young KU ; Soo Boo HAN ; Byung Moo MIN ; Seung Jin LEE ; Chong Pyoung CHUNG
The Journal of the Korean Academy of Periodontology 2004;34(4):781-790
No abstract available.
Chitosan*
;
Osteoblasts*
;
Transforming Growth Factor beta1
;
Transforming Growth Factors*
5.Research progress on the correlation between transforming growth factor- β level and symptoms of depression.
Yanran LI ; Huiying WANG ; Jiansong ZHOU ; Changhong WANG
Journal of Zhejiang University. Medical sciences 2023;52(5):646-652
Transforming growth factor (TGF)-β is a group of cytokines with anti-inflammatory effects in the TGF family, which participates in the development of stress and depression-related mechanisms, and plays roles in the regulation of inflammatory response in depression and the recovery of various cytokine imbalances. The core symptoms of depression is associated with TGF-β level, and the psychological symptoms of depression are related to TGF-β gene polymorphism. Various antidepressants may up-regulate TGF-β level through the complex interaction between neurotransmitters and inflammatory factors, inhibiting inflammatory response and regulating cytokine imbalance to improve depressive symptoms. Studies have shown that recombinant TGF-β1 protein has beneficial effects in mouse depression models, indicating TGF-β1 might be a potential therapeutic target for depression and nasal sprays having the advantage of being fast acting delivery method. This article reviews the research progress on dynamic changes of TGF-β level before and after depression treatment and the application of TGF-β level as an indicator for the improvement of depressive symptoms. We provide ideas for the development of new antidepressants and for the evaluation of the treatment efficacy in depression.
Animals
;
Mice
;
Transforming Growth Factor beta/metabolism*
;
Transforming Growth Factor beta1
;
Depression
;
Cytokines
;
Antidepressive Agents/therapeutic use*
;
Transforming Growth Factors
6.Localization of transforming growth factor beta1 in airway mucosa of toluene diisocyanate-induced asthma.
Soo Keol LEE ; Sun Min LEE ; Ki Baik HAHM ; Hyun Ee YIM ; Choon Sik PARK ; Sun Sin KIM ; Dong Ho NAHM ; Hae Sim PARK
Journal of Asthma, Allergy and Clinical Immunology 2001;21(3):500-507
BACKGROUND AND OBJECTIVE: There have been some reports on the expression of TGF beta-an anti-inflammatory and fibrosing cytokine in airway mucosa of asthmatics. However, the ex- pression of TGF beta1 in bronchial mucosa of TDI-induced asthma is not known. The aim of this study was to observe immunolocalization of TGF beta1 in airway mucosa of TDI-induced asthma. METHODS: TGF beta1 expressions were compared using immunohistochemistry in bronchial muco- sa from 22 subjects with TDI-induced asthma (group I: 10 newly diagnosed, group II: 12 subjects with persistent asthma symptoms for more than 4 years after diagnosis), and 8 non- asthmatics undergoing pneumonectomy from lung tumor. The distribution and intensity of expression were analyzed by two observers in four areas of bronchial tissue-epithelium(EP), vascular endothelium(VE), smooth muscle(SM), and mucous glands(MG). RESULTS: Positive rates of TGF beta1 expression for groups I and II in the four areas were as follows; EP (50% vs 100%, p<0.05), VE(40% vs 100%, p<0.05), SM(33.3% vs 100%, p<0.05), and MG(66.7% vs 80%, p>0.05). Grades of TGF beta1 expression of EP, VE, and SM were significantly higher in group II than in group I(p<0.05, respectively). There was no significant difference in distribution and intensity of TGF beta1 expression between TDI-induced asthma and controls(p>0.05, respectively). CONCLUSION: TGF beta1 expressions of EP, VE, SM and MG were noted in airway mucosa of TDI-induced asthma and expressions of EP, VE, and SM were more intense and frequent in patients with persistent asthma symptoms.
Asthma*
;
Humans
;
Immunohistochemistry
;
Lung
;
Mucous Membrane*
;
Pneumonectomy
;
Toluene*
;
Transforming Growth Factor beta1*
;
Transforming Growth Factors*
7.Stimulation of c-myc protooncogene expression by transforming growth factor a in human ovarian cancer cells.
Jeong Youn CHOI ; Young Sook HONG ; Hae Young PARK
Experimental & Molecular Medicine 1997;29(4):203-208
To investigate whether transforming growth factor alpha (TGF alpha) treatment of human ovarian cancer cells was associated with the induction of c-myc protooncogene, the expression of this gene in NIH:OVCAR-3 cells was examined. TGF alpha induced increase in c-myc mRNA level, with a peak after 1 h of treatment; this stimulation was dose-dependent, with an optimal concentration of 5 ng/ml TGF alpha. Its primary action is probably at the transcription level since the half-life of c-myc mRNA measured in the presence of actinomycin D was not modified by TGF alpha treatment. In addition, TGF alpha stimulation of c-myc mRNA did not require protein synthesis since it was not suppressed by cycloheximide treatment. Antisense phosphorothioate oligonucleotide to c-myc specifically inhibited the TGF alpha-stimulated c-Myc protein expression and growth of NIH:OVCAR-3 cells. Our results indicate that induction of c-myc expression by TGF alpha plays an important role in the growth of NIH:OVCAR-3 cells.
Cycloheximide
;
Dactinomycin
;
Half-Life
;
Humans*
;
Ovarian Neoplasms*
;
RNA, Messenger
;
Transforming Growth Factor alpha
;
Transforming Growth Factors*
8.A comparison Study of Expression of Transforming Growth factor - alpha in Keratoacanthomas and Squamous Cell Carcinomas.
Sung Kwi PARK ; Ho Sun JANG ; Kyung Sool KWON ; Tae Ahn CHUNG
Korean Journal of Dermatology 1996;34(2):227-232
BACKGROUND: Transforming growth factor-(TGF-alpha) is a acidic, heat-stable, 50 amino acid polypeptide which is related to cellular proliferation, malignant transformation, and angiogenesis. There are many similarities between keratoacanthoma(KA) and squamous cell carcinoma(SCC). So, it is often difficult to differentiate keratoacanthoma and squamous cell carcinoma, clinically and histologically. OBJECTIVE: Our purpose was to examine the patterns of TGF-alpha expression on KA and SCC using immunohistochemical staining and to evaluate the usefulness of the immunohistochemical staining with antihuman TGF-alpha antibody on differentiation between KA and SCC. METHODS: Formalin-fixed, paraffin-embedded specimens that had confirmed to KA(n=12) or SCC(n=10) were performed by immunoperoxidase staining with monoclonal antihuman TGF-alpha antibody RESULTS: All of KA dmonstrated a diffuse pattern within tumor lobules, but, at the peripheral rim of cells, showed unstained pattern. In contrast to KA, 40% of the SCC had patchy infiltration within tumor lobules, and 60% of the SCC had diffuse pattern which was similar to the pattern found in KA. All of SCC showed well-defined staining at peripheral cells. CONCLUSION: Immunohistochemical staining with antihuman TGF-alpha antibody could be used on differentiation between KA and SCC.
Carcinoma, Squamous Cell*
;
Cell Proliferation
;
Keratoacanthoma*
;
Transforming Growth Factor alpha
;
Transforming Growth Factors*
9.A comparison Study of Expression of Transforming Growth factor - alpha in Keratoacanthomas and Squamous Cell Carcinomas.
Sung Kwi PARK ; Ho Sun JANG ; Kyung Sool KWON ; Tae Ahn CHUNG
Korean Journal of Dermatology 1996;34(2):227-232
BACKGROUND: Transforming growth factor-(TGF-alpha) is a acidic, heat-stable, 50 amino acid polypeptide which is related to cellular proliferation, malignant transformation, and angiogenesis. There are many similarities between keratoacanthoma(KA) and squamous cell carcinoma(SCC). So, it is often difficult to differentiate keratoacanthoma and squamous cell carcinoma, clinically and histologically. OBJECTIVE: Our purpose was to examine the patterns of TGF-alpha expression on KA and SCC using immunohistochemical staining and to evaluate the usefulness of the immunohistochemical staining with antihuman TGF-alpha antibody on differentiation between KA and SCC. METHODS: Formalin-fixed, paraffin-embedded specimens that had confirmed to KA(n=12) or SCC(n=10) were performed by immunoperoxidase staining with monoclonal antihuman TGF-alpha antibody RESULTS: All of KA dmonstrated a diffuse pattern within tumor lobules, but, at the peripheral rim of cells, showed unstained pattern. In contrast to KA, 40% of the SCC had patchy infiltration within tumor lobules, and 60% of the SCC had diffuse pattern which was similar to the pattern found in KA. All of SCC showed well-defined staining at peripheral cells. CONCLUSION: Immunohistochemical staining with antihuman TGF-alpha antibody could be used on differentiation between KA and SCC.
Carcinoma, Squamous Cell*
;
Cell Proliferation
;
Keratoacanthoma*
;
Transforming Growth Factor alpha
;
Transforming Growth Factors*
10.Biological Effect of TGF
The Journal of the Korean Orthopaedic Association 1995;30(5):1489-1495
I have examined the effects of a growth factor, transforming growth factor(TGF)-B 1, on the rates of proteoglycan synthesis, aggregation potenital, and phenotypic expression of proteoglycans from human cervical intervertebral discs maintained in a cell culture system. A cell culture system for transitional and nuclear regions of degenerated human cervical intervertebral disc disc was devised to assess the biosynthetic response, assayed by 35S-sulfate incorporation into proteoglycan and protein synthesis assayed by 35S-methionine incorporation. And I had the data as the TGF-B 1 has an effect on the proteoglycan synthesis in quantitative and qualitative analysis in the cell culture system of the human intervertebral disc. TGF-B 1 may be used as a therapeutic alternative to degenerated disc disease.
Cell Culture Techniques
;
Humans
;
Intervertebral Disc
;
Proteoglycans
;
Transforming Growth Factors