Cardiovascular Diseases ; Humans ; Trans Fatty Acids

Cardiovascular System ; drug effects ; Humans ; Trans Fatty Acids ; adverse effects

BACKGROUND/OBJECTIVES: Compelling evidence indicates that consumption of trans-fatty acids (TFA) is associated with a wide range of diseases. However, few validated tools for TFA intake assessment are available in Korea. We aimed to validate a food frequency questionnaire (FFQ) estimating usual intake of TFA in Korean adults. MATERIALS/METHODS: Eighty-two healthy adults completed an FFQ with a 3-day diet record (3DDR), and 58 completed a second FFQ at a 1-month interval. To assess the reproducibility of the FFQ, we compared estimated TFA intakes from each FFQ. To assess the validity, we compared estimates from the FFQ with those from the 3DDR. RESULTS: The FFQ was reproducible (Spearman r = 0.71) and provided modest correlations with the 3DDR (Spearman r = 0.38). After adjustment for total energy intake, the correlations increased (r = 0.45). Measurement-error correction also de-attenuated the correlations (r = 0.57). When quintiles of the FFQ and 3DDR were joint-classified, 9% on average were misclassified into extreme quintiles. CONCLUSIONS: Our findings suggest that the developed FFQ is reproducible and reasonably valid in categorizing individuals according to TFA intakes among healthy young and middle aged adults in Korea.
Adult* ; Diet Records ; Energy Intake ; Humans ; Korea ; Middle Aged ; Surveys and Questionnaires* ; Trans Fatty Acids*

This study was done to determine the trans fatty acid (tFA) composition of human milk from postpartum to sixth months after delivery, to investigate the tFA intake of lactating women, and to estimate the intakes of tFA by infants exclusively fed breast milk. A total of 27 lactating Korean women participated to this study voluntarily, gave their breast milk, and responded to an investigation of their diets. The lactating women consumed 2.3-2.8 g/d of tFAs over the period of the first, second, third, and sixth months postpartum, which was 3.4-4.9% of the total fat intake and 0.8%-1.2% of the total energy intake. The proportions of tFAs in the breast milk were 1.89% in colostrum, 1.78% in transitional milk, and 1.78-2.25 in mature milk of the first, second, third, and sixth months postpartum. The tFAs of the breast milk identified in this study were C16:1n9t, C18:1n9t, C18:2n6t12t, C18:2 n6t12c, C18:2n6c12t and C18:2n6t11t. Among them, C18:1n9t was predominant, which made up 59.26% of all tFAs in colostrum, 62.36% in transitional milk, and 64.42% in mature milk. The proportion of total tFA was unchanged with time, although some significant differences were noted for individual tFAs. The percentages of C18:2n6t12c and C18:2n6c12t decreased over the study period. Estimated tFA intake of the exclusively breast-fed infants was 0.18 g/d when fed colostrum, 0.29 g/d when fed transitional milk, and 0.53 g/d when fed mature milk until the sixth month of postpartum. Those were 0.5%, 0.8%, and 1.1% of the total energy intake. The results in this study indicate that lactating Korean women consume not a large quantity of tFAs, secrete breast milk not containing much tFA, and the estimated intake of tFAs by infants fed exclusively breast milk is not great.
Breast* ; Colostrum ; Diet ; Energy Intake ; Female ; Humans ; Infant ; Milk ; Milk, Human* ; Postpartum Period* ; Trans Fatty Acids*

Recently, nonalcoholic fatty liver disease (NAFLD) is highly prevalent even in Korea, which has the potential to progress to cryptogenic cirrhosis and hepatocellular carcinoma. It is not only regarded as a hepatic component of the metabolic syndrome but also as an independent risk factor and a marker for increase in cardiovascular disease. We should keep in mind the NAFLD is a "treatable and have to treat" disease to prevent early death from liver and cardiovascular complications. Weight loss via lifestyle modification remains the most common and fundamental therapy advocated for reducing hepatic lipid in NAFLD. There is increasing evidence that exercise or physical activity beneficially modulates liver fat independent of weight loss. Although reduced total calorie intake potentially plays a role in the treatment of NAFLD, dietary macronutrient composition may also play a role. Low-carbohydrate and low-fructose diets are of particular benefit to reduce steatosis and improve biochemical tests. Polyunsaturated fatty acid (n3-PUFA) and monounsaturated fatty acid (MUFA) may play a protective role against increase liver fat. Limitation of Saturated fat and trans-fatty acids intake is very recommendable. Even lifestyle modifications continued to be the cornerstone of therapy in NAFLD, some insulin-sensitizing drug may be a more effective means in the treatment of NAFLD. Vitamin E and statins have demonstrated promising initial results in improving liver enzymes or features of liver histology. Bariatric surgery is very useful treatment option for morbidly obese NAFLD patients. However, weight loss medication is not recommended which have shown varying degrees of side effects for the treatment of NAFLD.
Bariatric Surgery ; Carcinoma, Hepatocellular ; Cardiovascular Diseases ; Diet ; Fatty Liver ; Fibrosis ; Humans ; Korea ; Life Style ; Liver ; Motor Activity ; Risk Factors ; Trans Fatty Acids ; Vitamin E ; Vitamins ; Weight Loss

Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease. The prevalence of NAFLD is growing gradually worldwide with increases in obesity, sedentary lifestyles, and an unbalanced diet. NAFLD ranges from simple steatosis without inflammation to steatohepatitis that can progress to cirrhosis. There is no single effective treatment that has widespread effects in NAFLD. The cornerstone of treatment is lifestyle modification, including weight reduction, diet, and physical activity. An approximately 7-10% weight reduction via diet or physical activity can improve the liver histopathology. Risk factors for NAFLD include a high-calorie diet, high-lipid diet, high-carbohydrate diet, saturated fatty acids, trans fatty acids, cholesterol, high fructose intake, and low-choline diet. Factors that protect against NAFLD include a low-calorie diet, low-carbohydrate diet, low-lipid diet, monounsaturated fatty acids (MUFA), polyunsaturated fatty acids (PUFA), dietary fiber, coffee, green tea, and light alcohol consumption. Physical activity also helps to manage NAFLD with or without weight reduction. Recent reports found that resistance training is as effective as aerobic training. Lifestyle modification has very low compliance. To maintain a treatment program, a multidisciplinary team approach is required that includes physicians, dietitians, physical trainers, and psychologists.
Alcohol Drinking ; Caloric Restriction ; Cholesterol ; Coffee ; Compliance ; Diet ; Dietary Fiber ; Fatty Acids ; Fatty Acids, Monounsaturated ; Fatty Acids, Unsaturated ; Fatty Liver* ; Fibrosis ; Fructose ; Inflammation ; Life Style* ; Liver ; Liver Diseases ; Motor Activity ; Nutritionists ; Obesity ; Prevalence ; Psychology ; Resistance Training ; Risk Factors ; Sedentary Lifestyle ; Tea ; Trans Fatty Acids ; Weight Loss

The method has been developed to accurately identify the magnitude of health risks and provide scientific evidence for implementation of risk management in food safety. It combines two parameters including consequence and likelihood of adverse effects based on risk matrix. Score definitions and classification for the consequence and the likelihood of adverse effects are proposed. The risk score identifies the intersection of consequence and likelihood in risk matrix represents its health risk level with different colors: 'low', 'medium', 'high'. Its use in an actual case is shown.
Consumer Product Safety ; Food ; classification ; Food Analysis ; methods ; statistics & numerical data ; Humans ; Likelihood Functions ; Risk Assessment ; Trans Fatty Acids ; adverse effects ; analysis

Gallstone disease represents one of the most common gastroenterological disorders. Several risk factors for cholesterol gallstone formation in the general population have been identified. There is a strongly increased risk of gallstone disease during prolonged fasting, rapid weight loss, total parenteral nutrition, and somatostatin analogue treatment. Cholecystectomy is the most frequently recommended conventional treatment for symptomatic gallstones. In asymptomatic and symptomatic gallstone carriers, treatment with the hydrophilic bile salt ursodeoxycholic acid (UDCA) has been claimed to reduce the risk of biliary colic and gallstone complications such as acute cholecystitis and acute pancreatitis. However, randomized, double-blind, placebo-controlled trials are lacking. There is evidence that dietary factors influence the risk of developing cholesterol gallstones. Dietary factors that may increase risk include cholesterol, saturated fat, trans-fatty acids, refined sugar, and possibly legumes. Obesity is also a risk factor for gallstones. Dietary factors that may prevent the development of gallstones include polyunsaturated fat, monounsaturated fat, fiber, and caffeine. Consuming a vegetarian diet is also associated with decreased risk. In addition, identification and avoidance of allergenic foods frequently relieves symptoms of gallbladder disease, although it does not dissolve gallstones. Nutritional supplements that might help prevent gallstones include vitamin C, soy lecithin, and iron. In addition, a mixture of plant terpenes (Rowachol(R)) has been used with some success to dissolve radiolucent gallstones.
Ascorbic Acid ; Bile ; Caffeine ; Cholecystectomy ; Cholecystitis, Acute ; Cholesterol ; Colic ; Diet* ; Diet, Vegetarian ; Fabaceae ; Fasting ; Gallbladder Diseases ; Gallstones* ; Iron ; Lecithins ; Obesity ; Pancreatitis ; Parenteral Nutrition, Total ; Plants ; Risk Factors ; Somatostatin ; Terpenes ; Trans Fatty Acids ; Ursodeoxycholic Acid ; Weight Loss

The childhood and adolescence is an important period for establishing lifelong health. If parents want their children to live a healthy life, they should fix their children a nutritionally balanced diet and they should encourage their children to have a healthy eating habits and active physical activity. The beginning of lifelong health should be breastfeeding which reinforces immunity. What parents need to do is preparing nutritionally balanced meals at certain place at regular times. Children themselves control the amount of food they need to take. The parents should be a role model of their children to improve their childrens' healthy lifestyle. After 2 years of age, fat intake must be gradually decreased to 30~35% of total energy intake. The parents should limit their children eating saturated or trans fatty acids. Sweet or salty taste should be given as late as possible, and the parents should make efforts to give their children fruits and vegetables at each meal. Also they have to serve milk, dairy products, beans, tofu which are abundant of calcium. Traditionally, physicians has been treating sick children but nowadays physicians have to ask about childrens' health before anything else and inform the parents what to do to keep their children healthy.
Adolescent ; Breast Feeding ; Calcium ; Child ; Dairy Products ; Diet ; Eating ; Energy Intake ; Fabaceae ; Fruit ; Humans ; Hypogonadism ; Life Style ; Meals ; Milk ; Mitochondrial Diseases ; Motor Activity ; Ophthalmoplegia ; Parents ; Soy Foods ; Trans Fatty Acids ; Vegetables

OBJECTIVETo understand the dietary intake levels of trans fatty acids (TFA) in a Chinese population and establish a basis for health risk assessment of trans fatty acids.

METHODSThe TFA contents data of 2613 food items and food consumption data of 10,533 people aged 3 years and above in two large cities in China were matched and a simple assessment method was used to estimate the distribution of dietary TFA intake.

RESULTSThe mean content of TFA was highest in margarine (1.68 ± 0.83 g/100g), followed by chocolate and candy (0.89 ± 2.68 g/100g), edible vegetable oils (0.86 ± 0.82 g/100g), milk (0.83 ± 1.56 g/100g), and bakery foods (0.41 ± 0.91 g/100g). TFA intake accounted for 0.34%, 0.30%, 0.32%, and 0.29% of the total energy intake in the 3-6, 7-12, 13-17, and ⋝18 year age groups, respectively. Of the populations studied, 0.42% demonstrated TFA intakes (as percentage of energy intake) greater than 1%. The main sources of dietary TFA intake were edible vegetable oils, milk, mutton, and beef, and baked foods, which accounted for 49.8%, 16.56%, 12.21%, and 8.87%, respectively.

CONCLUSIONThe current intake of TFA among people in two cities did not appear to be of major health concern regarding the threshold of TFA intake as the percentage of total energy recommended by the World Health Organization. Because most TFA were derived from industrially processed foods, the government should reinforce nutrition labeling and regulate food producers to further reduce TFA in food and to provide scientific instruction for consumers to make sound choices.

Adolescent ; Analysis of Variance ; Child ; Child, Preschool ; China ; Diet Surveys ; Dietary Fats ; administration & dosage ; analysis ; metabolism ; Energy Intake ; Female ; Food ; standards ; Food Analysis ; Humans ; Male ; Surveys and Questionnaires ; Trans Fatty Acids ; administration & dosage ; analysis ; metabolism