Some algorithms used in UV-Vis MCA spectrophotometry technique and some recent statistical approaches to the Advanced MCA technique were described. A number of pharmaceutical formulas containing 2-4 ingredients has been analyzed successfully using MCA technique. Basing on the basic algorithm of MCA and its statistical approaches, an applicable software for data processing had been established (running in Windows (environment - IBM compatible computer). This enables to use MCA technique for conventional spectrophotometers.
Pharmaceutical Preparations ; prevention & control

By bromation of isatin 5-bromoisatin (I) was obtained. On boiling (I) with 4% formaldehyde solution for short period of time, a compound was isolated which has been characterized as N-hydroxymethyl-5-bromoisatin (II). By condensation of I with various H2N-B compounds, 6 derivatives (III-VIII) were formed. The structures of the obtained products were characterized by IR spectroscopy (II was characterized by MS, 1H.NMR). The synthesized compounds were tested for biological activities such as antibacterial and antifungal. Among these, two compounds (I, II) showed an antibacterial activity on 8 strains of bacteria. Compound VI showed an antibacterial activity on 3 strains of bacteria. Compound VI showed an antibacterial activity on 3 strains of bacteria.
Bufotenin ; Anti-Bacterial Agents

By bromation of isatin, 5-bromoisatin (I) was obtained. Compound (I) underwent Mannich reaction and gave II with formaldehyde (36% aqueous solution) and morpholine. On treatment with the appropriate arylhydrazines, compound II gave 3-arylhydrazino-5-bromo-1-morpholinomethyl isatin (III-VIII). All synthesized compounds have been characterized by their IR, elemental analysis (II was characterized by MS, 1H.NMR). All synthesized compounds (I-VIII) were tested for biological activities such as antibacterial and antifungal. Among these, compounds I, II showed an antibacterial activity on 8 strains of bacteria
Anti-Bacterial Agents ; Isatin ; Antifungal Agents

The Sandmeyer isatin synthesis consisting of the condensation of primary arlamines with chloral and hydroxylamine to the corresponding isonitrosoacetanilides, and subsequent cyclization of the latter, was now applied with success to p-fluoroaniline, which gave 5-fluoroisatin (I). On treatment with the appropriate aryhydrazine compound I gave 3- aryhydrazine-fluoroisatin (II-VII). By the condensation of I with various p-X-C6H4NH2 compounds, 4 derivatives (VIII-XI) were formed. All synthesized compounds have been characterized by their IR and elemental analysis. 7 synthesized compounds (I-VII) were tested for biological activities such as antibacterial and antifungal. Among these, compounds I showed an antibacterial on 8 strains of bacteria and an antifungal activity against candidia albicans. compound VI showed an antibacterial activity on 2 strains of bacteria and an antifungal activity against candidia albicans.
Pharmaceutical Preparations ; Anti-Bacterial Agents

Synthesis and antibacterial and antifungal effects of some N-Mannich base of 5-fluoroisatin and their derivatives 5-fluoroisatin (I) has been prepared by the method of Sandmeyer (1919). Compound (I) underwent Mannich reaction and gave II, X with formaldehyde (36% aqueous solution) and secondary amine (morpholine and piperidine). On treatment with the appropriate arylhydrazines, compound II gave 3-arylhydrazino-5-fluoro-1-morpholinomethyl isatin (III-IX), compound X gave 3-arylhydrazino-5-fluoro-1-piperidinomethyl asatin (XI-XVI). All synthesized compounds have been characterized by IR, MS, 1H.NMR and elemental analysis. All synthesized compounds (I-XVI) were tested for biological activities such as antibacterial and antifungal. Among these, compounds I, II, X showed an antibacterial activity against Candida albicans. Compound XIII showed an antibacterial activity on 6 strains of bacteria. Compound XIV showed an antibacterial activity on 4 strains of bacteria. Compound V showed an activity on 2 strains of bacteria and compound XV showed an antibacterial activity on 1 strain of bacteria.
Pharmaceutical Preparations ; Anti-Bacterial Agents

By the condensation of 5-fluoroisatin with various p-X-C6H4NH2 compounds, 4 derivatives (I-IV) were formed. Compounds (I-IV) underwent Mannich reaction and gave V-XII with formaldehyde (36% aqueous solution) and secondary amine (morpholine and piperidine). All synthesized compounds hade been characterized by IR, MS and elemental analysis. All synthesized compounds (I-XII) were tested for biological activities such as antibacterial and antifungal. Among them, compound V showed an antibacterial activity on 6 strains of bacteria. Compound IX and X showed an antibacteria and antifungal activity against Candida albicans... Compound VI showed an antibacterial activity on 3 strains of bacteria. Compound XI and XII showed an antibacterial activity on 2 strains of bacteria.
Pharmaceutical Preparations ; antibacterial agents ; antifungal agents

The initial investigation of pesticides using cultivation of medical plants in ThietTru, BinhMinh, KhoaiChau, HungYen was reported. Almost pesticides in common use for cultivation of medicinal plants there were recorded and classified. The results of investigation showed that they were often used extensively and in a wrong way. although the Organo-chlorine pesticides (except endosulfan) were no longer in use but at least one prohibited pesticide (methamidophos) were still illegally overused. Further investigation in broader areas for some other localities should be undertaken for systematical evaluation of pesticides use in the cultivation of medicinal plants, and especially its impact. Residual pesticides in herbal medicines should be determined as well, since then, some active measure of management and method of control will be proposed in order to strengthen the quality assurance of this precious resource of medicines.
chemistry ; Pharmaceutical Preparations ; Plants, Medicinal ; Medicine, Traditional

In 6 simples of Nga Truat. 2 simples of Dia Lien, 2 samples of Cu Coc collected in Nghia Trai village. There was no-orgam chlorine pollutants; but in 1 of 9 samples of camomille containing cypermethrine residue exceeded the normal standard
Insecticides ; Medicine, Traditional ; Pharmaceutical Preparations

Back ground: The hypertension may lead the changes of the left ventricular geometry and the left ventricular diastolic dysfunction. There were many investigations about these abnormalities. Moreover, the treatment of the hypertensive patients with or without the left ventricular diastolic dysfunction is quite different. In Binh dinh general hospital, however, the left ventricular dysfuntion were neglected in practice. Thus, in this study, we evaluate the prevalence of these abnormalities in hypertensive patients. Subjects and method: We prospectively studied, from 6/2002 to 11/2003, 200 consecutive hypertensive patients admitted to the Internal Deparment at the Binh Dinh General Hospital. Echocardiography was performed on a Hewlett-Packard Image-Points with 2.5 and 3.5 MHz transducers. Measurements of the size of the ventricular walls are according to ASE. Doppler echocardiography is used to evaluate the characteristics of diastolic transmitral blood flow from the apical four-chaber view. The peak velocities of blood flow during early diastolic filling (E wave) and atrial contraction (A wave), the E-wave decelerating time and parameters of pulmonary venous flow revesal during atrial contraction are measured. The isovolumic relaxation time is measured from the apical-five chamber view. The diagnosis and classification of the left ventricular geometric changes and the abnormal diastolic filling patterns are based on the criteria of Devereux. Results: Prevalence of the left ventricular diastolic dysfunction was 61.5% of the hypertensive patients with the most frequent impaired relaxation pattern (48%). 72.5% of patients have the geometric changes in which the remodelling type consists of 47.5% concentric hypertrophy 25%.
Ventricular Dysfunction, Left ; Hypertension

A solid phase extraction (SPE) and GC-ECD for multi-residues determination of 14 organo-chlorinated pesticides (OCPs) in radix Pseudo-ginseng were introduced. Using n-hexane as extracting solvent and silica gel for clean up of sample extract, with GC-ECD analysis, good separation of 14 OCPs and carbophenothion(IS) was achieved on capillary column coated with poly(5% diphenyl) siloxane. Experiments showed that n-hexane is adequate as extracting solvent(percentage of recovery70% for 13 in total 14 analyses), the LOD was about 0.35 to 1.6 ppb for blank sample spiked with standards. The method has been carried out on 7 samples collected from market for preliminary investigation of its actual OCPs residues. For 14 OCPs being analysed, results showed that all samples to be examined are complied with requirements of MRL in USP 24 or in Eur. P97.We may conclude that those samples were cultivated in less contaminated soils or none of 14 OCPs was still in illegal use
Panax ; chemistry ; Drug Residues ; drugs