Introduce risk factors of hepatocellular carcinoma included infection of hepatitis B virus or hepatitis C virus, and coinfaction of hepatitis B virus and hepatitis C virus, mechanisms malignant transformations and pre-malignant lesions such as cirrhosis, pathohistological signs, structural and cytological changes
Carcinoma, Hepatocellular ; Carcinoma ; Adenoma, Liver Cell

Review and update some knowledge of alpha feto-protein (AFP) value in the diagnosis, prognosis and management of patients with hepatocellular carcinoma (HCC), and the role of AFP in monitoring of response to medical and surgical treatments. Serum AFP tests give sensitivity of 50% and specificity >90% at cut-off value of 500 ng/ml in the diagnosis of HCC in patients who had underlined hepatic diseases
Carcinoma, Hepatocellular ; Liver ; Liver Neoplasms

Background: Hepatitis B is a potentially serious form of liver inflammation due to infection by the hepatitis B virus (HBV). It occurs in both rapidly developing (acute) and long-lasting (chronic) forms, and is one of the most common chronic infectious diseases worldwide. HBV infection is very common in Thua Thien \ufffd?Hue. Objectives:. Our study is aimed to assess the efficacy and safety of Adefovir dipivoxil(ADV) in patients with HBeAg positive chronic hepatitis B .. Subjects and method: Design of study: Prospective; 36 patients with HbeAg (+) chronic B hepatitis were enrolled in this study, all patients were treated with Adefovir dipivoxil in 24 months at Hue University Hospital from October 2004 to September 2006 . Results: The rate of normalization of ALAT is 50 % after 6 months, 66.66% after 12 months and 69.44% after 24 months. The rate of HbeAg seroconversion is 11.11 % after 12 months and 30.55% after 24 months. This rate is Significantly higher in group of patients having the activity of SePT between 5 - 10 normal (58.33%). The rate of phenotypic resistance is only 2.77% after 12 months and 8.33% after 24 months. The tolerance is generally good\r\n', u'even in long - term treatment and no complication of renal\r\n', u'insufficiency was found. Conclusion: ADV appears an effective and safe in patients with HBeAg(+) chronic hepatitis. \r\n', u'
Hepatitis B ; Chronic/ pathology ; therapy ; Adenine/ analogs & ; derivatives

The main cause of the chronic pancreatitis were the chronic alcoholism (64%). The other etiology were hyperlipiderma (8%), malnutriation especially 16% patients had clinical biological and histogical evidences related protein malnutriation. The clinical condition were various: the abdominal pain were most common (92%). The position of pain, regardless the acute pain attack can help the diagnosis. The most comon complications were the disorder of glucose toleration (48%) and false cyst in the pancreas (32%), disorder of exocrine functions (24%) in long term studied group.
Pancreatitis, Chronic ; etiology ; diagnosis

Objectives: Assess some disorder of hemostasis in the patient of cirrhosis; Estimate the correlation between these disorders and the Child-Pugh score. Methods: 30 patients of cirrhosis diagnosed upon the clinical, biological and imaging criteria, in the Department of HepatoGastroEnterology, Hue Central Hospital, from January to October 2000. Results and conclusion: The frequency of the disorder of hemostasis in the patients of cirrhosis is about 92%, the most frequent of these disorders is the prolongation of prothrombine time (83.3%). A diminution of fibrinogen concentration was found in 46.7% the cases. Significant prolongation of the time of Howell and Cephalin - Kaolin time are found respectively in 53.4% and 40%. Thrombocytopenia occurs in only 6.7%. Clinical manifestations don't reflex exactly the disorders of hemostasis, bleeding in the peritoneal cavity was found in 13.3%. There isn't any strict correlation between Child-Pugh score (CPS) and any of the hemostasis disorders. Apart from a medium correlation between CPS and prothrombin time (r=0.56, p<0.05) and concentration of fibrinogen (r=0.62, p<0.05) and minimal correlation between CPS and time of Howell (r=0.32, p<0.05) and Time of Cephalin - Kaolin (r=0.30, p>0.05)
Fibrosis ; Blood Coagulation Disorders

Incidence of primitive liver cancer has the regularly increased in Asia as well as in Vietnam. Hepatitis B virus is proved as the most important causative factor by many epidemiological and molecular studies. In the pathogenesis, HBV acts via two mechanisms. The hepatitis B vaccination efforts, for all the new born babies and as well as for all the people HbsAg negative, is very necessary and urgent to reduce the incidence of PCL in the next decades
Hepatitis B ; Liver Neoplasms

Beside of causative agents of hepatitis B virus, recent studies start discovering the causative agent of hepatitis C virus for etiology of primary liver cancer. This virus plays a very dangerously because of its potential clinical conditions as well as having no effective vaccine for active prevention. The Hepatitis C virus impacts by both indirect and direct mechanism. A synergic impact of Hepatitis C virus and alcoholism as well as Hepatitis B virus has been proved
Hepatitis C ; Liver Neoplasms

This paper introduces the theoretical basis of the amplification of the polymerase chain reaction (PCR) in the diagnosis of hepatitis C and process of discovering the hepatitis C by PCR. This is a technique with the high sensitivity and very specificity and gives the results rapidly. However, the application of this technique requires many experiences and the deep knowledge for its limitation, especially contamination.
Hepatitis C ; Polymerase Chain Reaction

100 patients with HCC, diagnosed by the clinical, Alpha Foetoprotein, imaging and cytological criteria; 50 patients in the control group. Anti HCV are performed by the techniques of EIA. HCV RNA is detected by RT PCR (reverse transcriptase PCR). The molecular biological techniques are performed at the Central Bio-medical laboratory in Hanoi Medical School. The frequency of serum anti HCV(ELISA) and especially of HCV RNA (RT-PCR) in the patients with HCC is also significantly higher than the one in the group of control: Anti HCV and HCV RNA.The co infection HBV-HCV is not significant in the hepatocarcinogennesis in our study. This study showed that hepatitis B virus is an important etiologic factor in the hepatocarinogenesis in Thua Thien Hue. The role of HCV is also remarkable and the co infections HCV-HBV are not significant in our study
Carcinoma, Hepatocellular ; Hepatitis C virus

The biochemical changes among patients with hepatocellular carcinoma were various and common in which reduction of albumin synthesis (61%), reversion of A/G ratio (58%), bilirubinemia (21%), increases of SGOT (91%) and SGPT (82%) and these increases were direct proportional with progress of disease
Carcinoma, Hepatocellular ; Metabolism