An interventional controlled study was conducted on 90 overweight children aged 4-5 at MamNon Practizing HoaSen School ( interventional school ) and MamNon ThanhCong A school ( controlled school ), BaDinh district, Hanoi from Dec.2002 to Jun.2003. The overweight was assessed by Weight/Height index (W/H > +2 SD) in comparing with population of referrence NCHS (WHO,1995). Physical strength was assessed by some tests in combining. Results showed that the triceps skinfold thickness waist, hip ratio, light level overweight and obesity status and all other physical conditions were improved
Obesity ; Overweight ; child ; Child, Preschool

A cross-sectional study was carried out on 2466 children aged 4-6, and their parents or nursing subjects in Hanoi urban districts from March to August 2002. Results showed that 4.9% of children, the most in Central districts (Hoan Kiem, Ba Dinh, Hai Ba Trung) had overweight. The overweight ratio at the age of 4, 5, 6 was 4.2%, 4.5%, 6.1% respectively; in boy was 6.1% and girls was 3.8%, it trends to increase with time and urban regions. Concerning the age, the ratio of quick increase of weight before the first age is 36.6%. 2nd-3rd age was 23.8%, 4th-5th age 18.8%. The moderate and heavy overweight ratio is 2.2%, the lowest is 1.1% in 4 years old of age and the highest is 3.6% in 6 years old of age. The P:L:G ratio is 15:23:62. There is an obvious improvement in the nutrions regime, animal protein ratio is 57.3% and vegetable lipid 26.3%
Overweight ; Obesity ; Food

The study was carried out from March to August 2002 on 2.466 children of 4-6 years old at 22 maternal and primary school in 7 districts of Hanoi city. Their nutritional status had got obvious improvements, the rate of malnutrition according to the 3 criteria - weight/age, height/age, weight/height was at low levels. Children with low weight at birth and children of stunting form suffered from malnutrition were at risk of overweight in 6 years old with 2.6 times higher than normal children. Children with the weight above 3,6kg at birth were at risk of over weight in 4-6 year olds with 1.9 times higher. Mothers of overweight children had had educative levels higher than children of normal group and children of later parturition
Child ; Overweight ; Child Nutrition Sciences

Background: Reasonably and safe antibiotic uses not only benefit patients, but also limit the development of antibiotic-resistant bacteria. Objectives: To total up all antibiotics and their brand names used at Viet Duc Hospital; To describe and preliminarily evaluate the uses of antibiotics according to Altemeier classification. Subjects and method: The cross-sectional study was caried out on all patients at 11 clinical departments, who were treated by antibotics. Review medical records for information of antibiotic use and some related factors (pre-operative and post-operative diagnoses, kind of operations, type of operation according to Altemeier classification). Results and Conclusion: There were 9 classes of antibiotics with 25 antibiotics and 31 bran names used in Viet Duc Hospital. Antibiotics of beta-lactam class and imidazol were most commonly used. The rate of antibiotic prophylaxis was low, although clean wounds have been used many strong antibiotics such as cephalosporin III. In infected wounds, combination of Cefotaxom + Flagyl was used more common, but it notes that the situation of production ESBLs by bacteria was rather high in hospital settings. Microbiological tests weren\u2019t applied widely for infected operations.
Drug Resistance ; Bacterial ;

Diphenyleneiodonium (DPI) has been widely used as an inhibitor of NADPH oxidase (Nox) to discover its function in cardiac myocytes under various stimuli. However, the effects of DPI itself on Ca2+ signaling and contraction in cardiac myocytes under control conditions have not been understood. We investigated the effects of DPI on contraction and Ca2+ signaling and their underlying mechanisms using video edge detection, confocal imaging, and whole-cell patch clamp technique in isolated rat cardiac myocytes. Application of DPI suppressed cell shortenings in a concentration-dependent manner (IC50 of ≅0.17 µM) with a maximal inhibition of ~70% at ~100 µM. DPI decreased the magnitude of Ca2+ transient and sarcoplasmic reticulum Ca2+ content by 20%–30% at 3 µM that is usually used to remove the Nox activity, with no effect on fractional release. There was no significant change in the half-decay time of Ca2+ transients by DPI. The L-type Ca2+ current (ICa) was decreased concentration-dependently by DPI (IC50 of ≅40.3 µM) with ≅13.1%-inhibition at 3 µM. The frequency of Ca2+ sparks was reduced by 3 µM DPI (by ~25%), which was resistant to a brief removal of external Ca2+ and Na+. Mitochondrial superoxide level was reduced by DPI at 3–100 µM. Our data suggest that DPI may suppress L-type Ca2+ channel and RyR, thereby attenuating Ca2+-induced Ca2+ release and contractility in cardiac myocytes, and that such DPI effects may be related to mitochondrial metabolic suppression.

The objectives of this study were to examine the association between dietary factors and underweight and overweight adult Vietnamese living in the rural areas of Vietnam. A cross-sectional study of 497 Vietnamese aged 19 to 60 years (204 males, 293 females) was conducted in rural areas of Haiphong, Vietnam. The subjects were classified as underweight, normal weight, and overweight based on BMI. General characteristics, anthropometric parameters, blood profiles, and eating habits were obtained and dietary intake was assessed using 24-hour recalls for 2 consecutive days. A high prevalence of both underweight (BMI < 18.5 kg/m2) and overweight (BMI > or = 23 kg/m2) individuals was observed (14.2% and 21.6% for males and 18.9% and 20.6% for females, respectively). For both genders, the overweight group were older than the under- and normal weight groups (P = 0.0118 for males and P = 0.0002 for females). In female subjects, the overweight group consumed significantly less cereals (P = 0.0033), energy (P = 0.0046), protein (P = 0.0222), and carbohydrate (P = 0.0017) and more fruits (P = 0.0026) than the underweight group; however, no such differences existed in males. The overweight subjects overate more frequently (P = 0.0295) and consumed fish (P = 0.0096) and fruits (P = 0.0083) more often. The prevalence of both underweight and overweight individuals pose serious public health problems in the rural areas of Vietnamese and the overweight group was related to overeating and high fish and fruit consumption. These findings may provide basic data for policymakers and dieticians in order to develop future nutrition and health programs for rural populations in Vietnam.
Adult ; Aged ; Asian Continental Ancestry Group ; Body Weight ; Edible Grain ; Cross-Sectional Studies ; Eating ; Female ; Fruit ; Genome ; Humans ; Hyperphagia ; Male ; Overweight ; Prevalence ; Public Health ; Rural Population ; Thinness ; Vietnam

Artichoke (Cynara scolymus L.) is a perennial plant belonging to the Asteraceae family originating from the Mediterranean region. In Vietnam, there are some varieties of artichoke which are extensively cultivated and propagated in highland areas, however, there have been limited detailed scientific publications on the chemical composition and biological activity of artichoke grown in Vietnam. Therefore, this study provides a detailed description of the extraction, isolation, and structural determination of 20 natural secondary metabolites present in harvested artichoke. The antioxidant activity of the extract and the 9 isolated compounds are tested in 1,1-diphenyl-2-picrylhydrazyl radical scavenging and ex vivo malondialdehyde model. Among the selected compounds, 1-caffeoylquinic acid, 3-caffeoylquinic acid, chlorogenic acid, 4-caffeoylquinic acid, cynarin, 1,5-dicaffeoylquinic acid, 4,5-di-caffeoylquinic acid, cynaroside, and scolymoside exhibited strong radical scavenging activity with IC50 values ranging from 5.7 to 61.6 µM. In the malondialdehyde assay, 1,3-dicaffeoylquinic acid (or cynarin) showed the strongest activity with an IC50 value of 24.7 µM, followed by 1,5-di-caffeoylquinic acid (66.8 µM), and 4,5-di-caffeoylquinic acid (127.3 µM). This outcome contributes to establishing a database on the phytochemical and antioxidant activity of the Vietnamese artichoke.

Background: The Covid-19 pandemic that occurred at the end of 2019, especially the fourth wave in Vietnam, has affected the world not only in terms of economy, society, and physical health but also affected the mental health of population in general and of medical students in particular. The use of different coping methods may be protective or risk factors for mental health problems. Objectives: 1. To investigate the prevalence of anxiety, stress, and depression among medical students during the Covid -19 pandemic 2. To describe several coping behavior among medical students during the pandemic. Subjects and methods: A descriptive cross-sectional study conducted on 2350 students of medicine programme range from the first year to the sixth year in the school year 2021 - 2022 at Hue University of Medicine and Pharmacy. Using the DASS-21 scale to survey anxiety, depression and stress in research subjects and a self-designed questionnaire to describe the coping methods of medical students. Results: out of 2350 sample, the prevelance of depression, anxiety, and stress was 38%, 33.2%, and 17% respectively. 13.8% had both anxiety and stress, 15.4% had both stress and depression, and 12.8% had a combination of anxiety, depression and stress. Coping behavior was commonly selected including: eating and sleeping regularly as usual (68.1%); doing exercise at home at least 5 days/week and 30 minutes/day (23.9%); 36.5% of students performed their favorite activities under appropriate conditions most of the time or often. In addition, 59.7% of students had learn new things on the internet, 4.5% of students had practiced meditation and relaxation, 2.9% of students had chosen to write a diary and things they were grateful for; 32% had still maintain contacted with friends via video calls, text messages and 34.4% had chosen to participate in volunteer activities. Conclusion: This study highlights a high rate of anxiety, stress and depression among medical students during the fouthth wave of the Covid-19 pandemic. Personal lifestyle changes and social activities were amongst the most comon coping behavior reported.