1.Study on placing fluid stents in anterior chamber to treat ocular hypertension and neovascular glaucoma
Journal of Practical Medicine 2004;474(3):22-24
37 eyes (of 37 opthalmic patients) underwent placing fluid stents. Results of the study showed that this speration carried on the eyes which underwent many previous operations with complicated pathology and high risk of late complications can lead to tubal obstruction, blocking the fluid flow and enhancing the optic pressure make the last solutions for resolving the high optic pressure impossible and conserving eyeball.
Hypertension
;
Glaucoma, Neovascular
;
Therapeutics
2.Comment about paraneoplastic syndrome in patients with lung cancer at Department of Respiratory in Bach Mai Hospital from 2003 to 2005
Thanh Hoang Tran ; Minh Nguyet Vu
Journal of Medical Research 2007;53(5):52-56
Background: Paraneoplastic syndrome is a rare syndrome on lung cancer patients in Vietnam and in the world. Objective: To define the percentage of the common paraneoplastic syndromes on lung cancer patients and research the clinical and investigations of these syndromes. Subjects and method: A study included 570 patients diagnosed lung cancer based on histopathological and cytological evidences, treated in Department of Respiratory in Bach Mai Hospital from 2003 to 2005. This was a descriptive, retrospective study. Results and conclusions: 19.47% of the patients had common paraneoplastic syndromes. Pierre Marie's syndrome was the most common (65.8%), followed by Schwartz-Bartter's syndrome (25.2%). 64.8% of the patients were 50 to 69 years old, 88.3% were men, 83.8% were smokers. 66.6% of patients were the severe periods. 30.7% of patients were diagnosed histologically adenocarcinoma. 12.8% of patients had Pierre Marie's syndrome, 5.3% had Schwartz-Bartter's syndrome, 1.9% had hypercalcemia of malignancy and 1.9% had thromboembolism.
Lung Neoplasms/ pathology
;
Paraneoplastic Syndromes/ pathology
3.Identification of Phenolic Compounds from Vietnamese Artichoke (Cynara scolymus L.) Leaf and Their Antioxidant Activities
Anh Nguyet Thi NGUYEN ; Thanh Tuyen Thi VU ; Hong Tuoi Thi DO ; Thien Hai NGUYEN ; Huan Van LE ; Hong Khuyen Thi PHAM ; Phu Chi Hieu TRUONG ; Dong Phuong PHAM ; Manh Hung TRAN
Natural Product Sciences 2024;30(1):39-51
Artichoke (Cynara scolymus L.) is a perennial plant belonging to the Asteraceae family originating from the Mediterranean region. In Vietnam, there are some varieties of artichoke which are extensively cultivated and propagated in highland areas, however, there have been limited detailed scientific publications on the chemical composition and biological activity of artichoke grown in Vietnam. Therefore, this study provides a detailed description of the extraction, isolation, and structural determination of 20 natural secondary metabolites present in harvested artichoke. The antioxidant activity of the extract and the 9 isolated compounds are tested in 1,1-diphenyl-2-picrylhydrazyl radical scavenging and ex vivo malondialdehyde model. Among the selected compounds, 1-caffeoylquinic acid, 3-caffeoylquinic acid, chlorogenic acid, 4-caffeoylquinic acid, cynarin, 1,5-dicaffeoylquinic acid, 4,5-di-caffeoylquinic acid, cynaroside, and scolymoside exhibited strong radical scavenging activity with IC50 values ranging from 5.7 to 61.6 µM. In the malondialdehyde assay, 1,3-dicaffeoylquinic acid (or cynarin) showed the strongest activity with an IC50 value of 24.7 µM, followed by 1,5-di-caffeoylquinic acid (66.8 µM), and 4,5-di-caffeoylquinic acid (127.3 µM). This outcome contributes to establishing a database on the phytochemical and antioxidant activity of the Vietnamese artichoke.