In Vietnamese indigenous medicine, the leaves of Artocarpus tonkinensis A-chev are used for treatment of lumbago and myoasthenia. Our study finds the flavonoid fraction from leaves of Artocarpus tonkinensis A-chev, is a potential antioxidant agent - Kaemferol in the total flavonoid fraction and it has an inhibitory effect against the lipid peroxydation of liver
flavonoids ; Liver ; Plants, Medicinal ; Medicine, Traditional

The experimental trials was conducted on Swiss white mice of 7 weeks of age, both sexes, and weight of 20-22g. Results: SOD activity in mice with ischemia/reperfusion was significantly statistical lower than those in the control group, p<0.05. In the group treated by “activating the blood and clearing the obstruction” formula with dose of 200 mg/kg, SOD activity was lower than those in the research group (89.5%) and was 73.7% compared to control group. In the group treated by this formula with dose of 300 mg/kg, SOD content was still lower than those in the research group (96%) and was 79.5% compared to control group. In the group treated by the dose of 500 mg/kg, SOD activity was higher significantly than those in the research group (113.6%) and was 96% compared to control group. The result showed that with appropriate dose, this medicinal formula has antioxidant effects
Brain Injuries ; Mice ; Ischemia ; Reperfusion

Radix Polygoni multiflori has been used Vietnamese traditional medicine for a long time. This paper presented the remarkable antioxidant effects of the AcOET extract from Radix Polygoni multiflori with evidences obtained from various antioxidant tests: inhibition of lipid peroxidation in cell hemogenates, of anion superoxide production, stimulation of SOD activity using Ransod kits. The extract protected the splenocytes from H20¬2- induced injuries and protected brain cells from oxidative stress caused by an ischemia/reperfusion course. These results suggested that application of Radix Polygoni multiflori as antioxidant agent will be beneficial in prevention and treatment of diseases of the elderly
Acetates ; Antioxidants

Objective: In Viet Nam, tuberculosis (TB) prevalence surveys revealed that approximately 98% of individuals with pulmonary TB have TB-presumptive abnormalities on chest radiographs, while 32% have no TB symptoms. This prompted the adoption of the “Double X” strategy, which combines chest radiographs and computer-aided detection with GeneXpert testing to screen for and diagnose TB among vulnerable populations. The aim of this study was to describe demographic, clinical and radiographic characteristics of symptomatic and asymptomatic Double X participants and to assess multilabel radiographic abnormalities on chest radiographs, interpreted by computer-aided detection software, as a possible tool for detecting TB-presumptive abnormalities, particularly for subclinical TB. Methods: Double X participants with TB-presumptive chest radiographs and/or TB symptoms and known risks were referred for confirmatory GeneXpert testing. The demographic and clinical characteristics of all Double X participants and the subset with confirmed TB were summarized. Univariate and multivariable logistic regression modelling was used to evaluate associations between participant characteristics and subclinical TB and between computer-aided detection multilabel radiographic abnormalities and TB. Results: From 2020 to 2022, 96 631 participants received chest radiographs, with 67 881 (70.2%) reporting no TB symptoms. Among 1144 individuals with Xpert-confirmed TB, 51.0% were subclinical. Subclinical TB prevalence was higher in older age groups, non-smokers, those previously treated for TB and the northern region. Among 11 computer-aided detection multilabel radiographic abnormalities, fibrosis was associated with higher odds of subclinical TB. Discussion: In Viet Nam, Double X community case finding detected pulmonary TB, including subclinical TB. Computer-aided detection software may have the potential to identify subclinical TB on chest radiographs by classifying multilabel radiographic abnormalities, but further research is needed.