Some algorithms used in UV-Vis MCA spectrophotometry technique and some recent statistical approaches to the Advanced MCA technique were described. A number of pharmaceutical formulas containing 2-4 ingredients has been analyzed successfully using MCA technique. Basing on the basic algorithm of MCA and its statistical approaches, an applicable software for data processing had been established (running in Windows (environment - IBM compatible computer). This enables to use MCA technique for conventional spectrophotometers.
Pharmaceutical Preparations ; prevention & control

By bromation of isatin 5-bromoisatin (I) was obtained. On boiling (I) with 4% formaldehyde solution for short period of time, a compound was isolated which has been characterized as N-hydroxymethyl-5-bromoisatin (II). By condensation of I with various H2N-B compounds, 6 derivatives (III-VIII) were formed. The structures of the obtained products were characterized by IR spectroscopy (II was characterized by MS, 1H.NMR). The synthesized compounds were tested for biological activities such as antibacterial and antifungal. Among these, two compounds (I, II) showed an antibacterial activity on 8 strains of bacteria. Compound VI showed an antibacterial activity on 3 strains of bacteria. Compound VI showed an antibacterial activity on 3 strains of bacteria.
Bufotenin ; Anti-Bacterial Agents

By bromation of isatin, 5-bromoisatin (I) was obtained. Compound (I) underwent Mannich reaction and gave II with formaldehyde (36% aqueous solution) and morpholine. On treatment with the appropriate arylhydrazines, compound II gave 3-arylhydrazino-5-bromo-1-morpholinomethyl isatin (III-VIII). All synthesized compounds have been characterized by their IR, elemental analysis (II was characterized by MS, 1H.NMR). All synthesized compounds (I-VIII) were tested for biological activities such as antibacterial and antifungal. Among these, compounds I, II showed an antibacterial activity on 8 strains of bacteria
Anti-Bacterial Agents ; Isatin ; Antifungal Agents

The Sandmeyer isatin synthesis consisting of the condensation of primary arlamines with chloral and hydroxylamine to the corresponding isonitrosoacetanilides, and subsequent cyclization of the latter, was now applied with success to p-fluoroaniline, which gave 5-fluoroisatin (I). On treatment with the appropriate aryhydrazine compound I gave 3- aryhydrazine-fluoroisatin (II-VII). By the condensation of I with various p-X-C6H4NH2 compounds, 4 derivatives (VIII-XI) were formed. All synthesized compounds have been characterized by their IR and elemental analysis. 7 synthesized compounds (I-VII) were tested for biological activities such as antibacterial and antifungal. Among these, compounds I showed an antibacterial on 8 strains of bacteria and an antifungal activity against candidia albicans. compound VI showed an antibacterial activity on 2 strains of bacteria and an antifungal activity against candidia albicans.
Pharmaceutical Preparations ; Anti-Bacterial Agents

Synthesis and antibacterial and antifungal effects of some N-Mannich base of 5-fluoroisatin and their derivatives 5-fluoroisatin (I) has been prepared by the method of Sandmeyer (1919). Compound (I) underwent Mannich reaction and gave II, X with formaldehyde (36% aqueous solution) and secondary amine (morpholine and piperidine). On treatment with the appropriate arylhydrazines, compound II gave 3-arylhydrazino-5-fluoro-1-morpholinomethyl isatin (III-IX), compound X gave 3-arylhydrazino-5-fluoro-1-piperidinomethyl asatin (XI-XVI). All synthesized compounds have been characterized by IR, MS, 1H.NMR and elemental analysis. All synthesized compounds (I-XVI) were tested for biological activities such as antibacterial and antifungal. Among these, compounds I, II, X showed an antibacterial activity against Candida albicans. Compound XIII showed an antibacterial activity on 6 strains of bacteria. Compound XIV showed an antibacterial activity on 4 strains of bacteria. Compound V showed an activity on 2 strains of bacteria and compound XV showed an antibacterial activity on 1 strain of bacteria.
Pharmaceutical Preparations ; Anti-Bacterial Agents

Analysis of measles data of the Northern region in 2000 indicated that the disease spread widely in all provinces and all the year round. However, it mostly occurred in spring, and in this season measles outbreaks were also often recorded, 36 out of 48 measles outbreaks were confirmed by serological diagnosis. Most of the measles cases were recorded in age group 5-15 years old. Most of the measles cases in immunized children were in the age group 5-9 years. The results: the confirmed measles cases appeared in big cities, delta provinces as well as in midland and mountainous provinces. There was no significant difference regarding sex. The symptoms usually observed in the measles cases were fever, cough, coryza, rash and conjunctivitis
Measles ; Measles Vaccine

Acute subdural hematoma (ASH) is a first cause of mortality of cranio cerebral traumatism. The high rate of mortality 50 to 90% after surgery, confirms to the published data of foreign authours, there remains a difficulty in establishing the prognosis of the disease. This study included 148 cases of ASH after surgery for finding the following factors: mechanism of trauma, age, sex, GOS, image in CT scanner, timing trauma of surgery influencing on the final results. Good results: 37.16%; Bad results: 62.84%.
Hematoma, Subdural ; surgery ; therapeutics

The rate of polio vaccine immunization coverage of children aged under 5 in National Immunization Days in Northern Region of Vietnam in November and December in 1997 reached 99.3%.
Poliovirus Vaccine, Inactivated ; immunization ; child

By the condensation of 5-fluoroisatin with various p-X-C6H4NH2 compounds, 4 derivatives (I-IV) were formed. Compounds (I-IV) underwent Mannich reaction and gave V-XII with formaldehyde (36% aqueous solution) and secondary amine (morpholine and piperidine). All synthesized compounds hade been characterized by IR, MS and elemental analysis. All synthesized compounds (I-XII) were tested for biological activities such as antibacterial and antifungal. Among them, compound V showed an antibacterial activity on 6 strains of bacteria. Compound IX and X showed an antibacteria and antifungal activity against Candida albicans... Compound VI showed an antibacterial activity on 3 strains of bacteria. Compound XI and XII showed an antibacterial activity on 2 strains of bacteria.
Pharmaceutical Preparations ; antibacterial agents ; antifungal agents

This research aims to identify the prevalence of reproductive tract infections (RTIs) and to investigate the knowledge of married women with child bearing age about RITs as well as their practices in treatment and prevention of these diseases. The research was conducted in Thuy Dzung commune- Thai Thuy District - Thai Binh province in 1996-1997. Both quantitative and qualitative methods were applied in this research. In cross sectional study, clinical and para clinical examinations and questionnaires were applied in 609 married women aged 15-49. The prevalence of RTIs was 32.8% (95% CI: 32.8% +/- 3.7). Among these infections, 28.5% of the cases were due to candida, 44% due to bacteria and 27.5% due to both candida and bacteria. The qualitative study was implemented in 7 months in 70 married and some men, health workers.The result shows that both local people and health workers perceived STDs as separate diseases,meaning that RTIs do not include STDs and hardly related with them. Free drugs and free health services are not enough, it is more important that the health workers are better able to deal with comon RTIs, and to counsel and help local women to prevent these diseases.
Infection ; Rural Health