In vitro and invivo anticancer activity of cisplatin on experimantal model of cancer. In comparison with the controls, a single dose of Cisplatin of 8 mg/kg of animal body weight was injected in mouse. The preparation inhibited completely the formation of ascitic fluid in mice bearing sarcoma 180. the biomass of the sarcome was minished by 99,5%, with anti – tumor effcacy (+++) according to H. to kawa scale (1989). Cisplatin (produced by the central babrik of planta medic) blocked 68% of mitotic index of cancer cells. The increase in life span of cancer mice treated by cisplatin was 130% more than that of the controls (39,2 days versus 17 days) 70% of treated mice survived after 27 days
Antineoplastic Agents ; Pharmaceutical Preparations ; Neoplasms

30 Swiss mice inoculated by the i.p injection of 106 Sarcoma TG. 180 ascitic cells per each one. 10 mice were injected (i.p) only one with 35mg/kg dosage of complex at the 10th day after tumor inoculation. Another 10 mice were got ascites out of them and the injected drugs as above mentioned. Our experiments have got the following results: average life span of control mice is 14 days. Nonoperative treated mice: 22 days (increase 57.1%), one mouse was survived. Postoperative treated mice: 40 days (increase 185.7%), two mice were survived.
neoplasms ; Mice

20 Swiss white mice were inoculated by the i.p route of 106 Sarcoma TG-180 ascitic cells per an animal. 10 mice were used as the control; 10 mice were treated by injecting (i.p) with 8mg/kg of Cis-platin produced in Vietnam on the 4th day after tumor cell transplantation. In comparison with the control mice, the treated ones have shown the results as follows: The prolongation of life span of the treated mice was 40% more than the controls (14.5 days and 20.3 days respectively).
Mice ; Pharmaceutical Preparations

Background: Dengue fever remains a major public health problem in Vietnam. It was transmitted through two main Aedes species, namely Aedes aegypti and Aedes albopictus in which Aedes aegypti played the predominant role in transmitting the dengue viruses (accounted for 94% of the Aedes genus).Different groups of insecticides have been widely used in the community. As a consequence, it increased the resistance level of Aedes vectors to the insecticides. Therefore, a new synthesized insecticide was required for future control and prevention of dengue epidemics. \r\n', u'Objectives: To evaluate the efficacy of Cynoff 25 ULV in suppressing Aedes species in Vietnam. \r\n', u'Subjects and methods: The study was conducted in the entomology laboratory and in the fields of Ha Tay province. ULV spraying was implemented in Hiengiang commune, Thuongtin district, in comparison with a control area, Van Mo commune in Ha Dong town.\r\n', u'Results and conclusions: : Cynoff 25 ULV had a high efficacy that kills over 90% of 2 dengue vector species, namely Aedes aegypti and Aedes albopicctus after 24 hours exposure at the distance of 30 meters from the brass nozzle of a STIHL SR 400 sprayer. In the field trials, Cynoff 25 ULV also had high efficacy in killing Aedes species, e.g. 100% of Aedes species were killed after spraying and the effects lasted for 3 months for Aedes aegypti and one month for Aedes albopictus species. The insecticide had no side-effects or any other adverse effects to humans, livestock and the environment in the intervention areas. \r\n', u'
cynoff 25 ULV ; aedes species ; dengue vectors

Background: Two species, Aedes aegypti and Aedes albopictus are the main intermediate vectors of transmission of the dengue viruses in Vietnam. Insecticide applications by different methods that may help interrupt the spread of dengue outbreaks. Many different groups of insecticides have been used for dengue vector control. Some recent studies revealed that Aedes vectors obscuring their resistance to insecticides at different levels. Therefore, a new insecticide formula is required for effective dengue vectors control. Objective: To evaluate the efficacy of Bistar 80SC by residual application in suppression of Aedes species in a northern province of Vietnam. Subject and methods: Bistar 80 SC with a component of Bifenthrin 80g/L was evaluated by residual application in suppression of 2 Aedes species in vitro and in an intervention commune of Hien Giang, Thuong Tin district and a control commune of Van Mo, Ha Dong town, Ha Tay province from March, 2004 to June, 2004. Results: WHO Bifenthrin paper test kit was effective at the concentration of 37.5mg/m2 and over with Aedes aegypti vectors ranged from 80% to 100% mortality in the North, In other words, Aedes vector remains susceptible to Bifenthrin in the region. The mortality on wood surface after 60 minutes of exposure to Bistar 80SC at concentrations of 25mg/m2 by using residual application was higher than those on brick walls. Up to 100% Aedes aegypti was killed after 60 minutes in exposure and remains in effect until the end of the third months and one month with Aedes albopictus. No side effects, to the sprayer and humans, livestock and environment caused by Bistar 80SC were reported in the intervention area. Conclusion: Bistar 80SC is suggested as a nominated alternative to effectively control the dengue outbreak by residual application.
Bistar 80SC ; dengue vectors