The 2- hydroxy-4,6-dimethyl pyrimidine (8),2-amino-4,6 –dimethyl pyrimidine (10) and sulfamet-hazine(1)were prepared by condensation of urea (4), guanidine (5) or sulfaguanidine (6) with acetylacetone(7) and then the 2-chloro-4,6-dimethyl pyrimidine (9) was obtained by treating the compound (8) with phosphorylchoride (POCl3)
Biological Products ; chemistry ; pharmacy

C-reactive protein (CRP) is an acute-phase protein in normal serum which increases significantly with tissue necrosis due to inflammation. To discover the level of protein C-reactive as a screening parameter for inflammatory diseases and rheumatic diseases, the CRP latex quick test was performed in 172 patients who were treated at the Rheumatology Dep. Bach mai Hospital from 2/1998 to 2/1999. The result shown that 100% patients with rheumatic fever had CRP positively, as well as 85,4% patients with rheumatics arthritis, 75% patients with connective disorders, 70% patients with ankylosing spondilitis and 20% patients with osteoarthritis. CRP is a valuable screening test in acute rheumatic arthritis as a routine diagnostic test, especially with the group of patients with rheumatic fever. However, this examination has an adequate sensitivity and specificity as well as erythrocyte sedimentation rate (ESR).
Rheumatic Diseases ; C-Reactive Protein

This research aims to identify the prevalence of reproductive tract infections (RTIs) and to investigate the knowledge of married women with child bearing age about RITs as well as their practices in treatment and prevention of these diseases. The research was conducted in Thuy Dzung commune- Thai Thuy District - Thai Binh province in 1996-1997. Both quantitative and qualitative methods were applied in this research. In cross sectional study, clinical and para clinical examinations and questionnaires were applied in 609 married women aged 15-49. The prevalence of RTIs was 32.8% (95% CI: 32.8% +/- 3.7). Among these infections, 28.5% of the cases were due to candida, 44% due to bacteria and 27.5% due to both candida and bacteria. The qualitative study was implemented in 7 months in 70 married and some men, health workers.The result shows that both local people and health workers perceived STDs as separate diseases,meaning that RTIs do not include STDs and hardly related with them. Free drugs and free health services are not enough, it is more important that the health workers are better able to deal with comon RTIs, and to counsel and help local women to prevent these diseases.
Infection ; Rural Health

Testing for antinuclear antibodies are useful in evaluation of autoimmune disorders. Anti-nuclear antibodies are detected by a variety of techniques including indirect immuno-fluorescence, enzyme immuno-fluorescence, enzyme immunocytochemistry, and ELISA. In this study, anti-n-DAN quick test was performed on 127 patients who are treated at Rheumatology Department of Bach Mai Hospital from December 1997 to February 1999. Diagnosis in each of these disorders was based on the American College of Rheumatology criteria (ACR). The results shown that, anti-n-nDNA was positive in 84.6% patients with systemic lupus erythematosus (SLE), 24.4% patients with systemic sclerosis and only 8.3% patients with rheumatoid arthritis, respectively. Anti-n-DNA quick test is simply and easy to perform but specificity and sensitivity of this method are still limited to compare with others.
Antibodies, Antinuclear ; Autoimmune Diseases ; diagnosis ; therapeutics

50 samples of blood from patients diagnosed as betathalassemia in the center for blood transfussion and cryopreservation at minus 20oC and studied in the Mahidol University, where, DNA extracted by phenol and chloroform and the mutation analysed by technique of PCR and RDBH. The investigation of mutation that caused thalassemia help to establish the Center for the prenatal diagnosis, prevention and control of thalassemia in Vietnam.
beta-Thalassemia ; diagnosis ; mutation

The study was carried on 3 communes of Giao Thuy district, 2 communes of Xuan Truong district, Nam Dinh province and 3 communes of Dong Hung district, Thai Binh province. The results showed that hemoglobin levels are similar between two genders, reduce gradually consistent with age and are lowest in interior field residents. Total cholesterol level at more than 5.2mmol/l accounts for average of 12.4%; triglycerid level at more than 2.3mmol/l accounts for average of 19.9% and HDL cholesterol at less than 0.9mmol/l makes 26.4%. The rates are highest in older population. These indices have high rate in town areas, followed by coastal areas and lowest in interior field areas. The mean rate of older people who have dyslipidemia is 5.1%.
Aged ; blood

From June 1995 to March 2002, in Hospital 103, we have performed surgical intervention for treatment of 47 cases with postoperative relapse of thyroid cancer. Some results obtained as follows: incision made on the scar of previous operation, expanding to one side of the neck in 55.31% and to both sides of the neck in 36.17%. There are 2 incision expanding to mediastinum by total midline stemotomy to localize and expose the trachea before to expose the tumor from post-lateral side and to resect the tumor from its tracheal side to lateral side.
Thyroid Neoplasms ; Recurrence

An investagation was performed on 214 patients with the diagnosis of beta thalassemia in Ho Chi Minh City Hospital of Hematology and Blood Transfusion. Studying process composes of an extration of DNA and its multiplication in synthetic reaction chain of a 4 segment linking fractions and the detection of gene mutation with Bio-Rad’s kit of mD TM betha Gene. Results showed a demonstration of 8 mutations in the Rit of mDx, but some mutations such as CD95IVS1, CD19IVS5. The mutation type at the site of codon 26HbE (G-A) was at highest rate (31%) following with CD41-42, CD17, CD28. The application of the techniques of detection of various mutation has a necessary role in developing continues to improve the prevention of diseases.
Mutation ; Thalassemia ; Diseases ; epidemiology

Study on some influencing factors such as buffer, antioxidant substances to build primary formulation of tobramycin eye drops with stability over 12 months. Result: temperature and light have much influence to the stability of tobramycin and pH contents of eye drops solution. High temperature impacts clearly to the decrease of tobramycin pH and contents. The solution was stable with borate buffer more than phosphate and citrate buffer. Product samples without antioxidant substances have low remained tobramycin contents, about 70% after three months ageing. Dinatri EDTA, natri bisulfit and dinatri EDTA-natri bisulfit combination have significant effect to the stable of tobramycin content. However, dinatri EDTA choice compared with dinatri EDTA-natri bisulfit combination is the same because of dinatri EDTA effect. Dinatri EDTA has better effect to the stable of pH and increase anti-bacteria effect of benzalkonium chloride
Ophthalmic Solutions ; Tobramycin ; Drug Stability

From the year 1993 to 2003, at the Hospital 19-8, 21 cases of intestinal obstruction due to food waste were treated surgery. Clinically, intestinal food waste obstruction had been moderately in progress. For diagnosis, clinics have to combine with X-ray and ultrasound. The damage was mainly seen in the intestine, but also in the stomach, and not in the colon. The operation for opening the fraction of intestine above the obstruction site for removing the food waste, then suturing immediately. This had demonstrated the effect. If the trauma was occurred late, because of the risk of rupture of the binding in the open site, the cutting-off intestine fragment was recommended.
Diagnosis ; Therapeutics ; Intestinal Obstruction