The 2- hydroxy-4,6-dimethyl pyrimidine (8),2-amino-4,6 –dimethyl pyrimidine (10) and sulfamet-hazine(1)were prepared by condensation of urea (4), guanidine (5) or sulfaguanidine (6) with acetylacetone(7) and then the 2-chloro-4,6-dimethyl pyrimidine (9) was obtained by treating the compound (8) with phosphorylchoride (POCl3)
Biological Products ; chemistry ; pharmacy

An investagation was performed on 214 patients with the diagnosis of beta thalassemia in Ho Chi Minh City Hospital of Hematology and Blood Transfusion. Studying process composes of an extration of DNA and its multiplication in synthetic reaction chain of a 4 segment linking fractions and the detection of gene mutation with Bio-Rad’s kit of mD TM betha Gene. Results showed a demonstration of 8 mutations in the Rit of mDx, but some mutations such as CD95IVS1, CD19IVS5. The mutation type at the site of codon 26HbE (G-A) was at highest rate (31%) following with CD41-42, CD17, CD28. The application of the techniques of detection of various mutation has a necessary role in developing continues to improve the prevention of diseases.
Mutation ; Thalassemia ; Diseases ; epidemiology

Study on some influencing factors such as buffer, antioxidant substances to build primary formulation of tobramycin eye drops with stability over 12 months. Result: temperature and light have much influence to the stability of tobramycin and pH contents of eye drops solution. High temperature impacts clearly to the decrease of tobramycin pH and contents. The solution was stable with borate buffer more than phosphate and citrate buffer. Product samples without antioxidant substances have low remained tobramycin contents, about 70% after three months ageing. Dinatri EDTA, natri bisulfit and dinatri EDTA-natri bisulfit combination have significant effect to the stable of tobramycin content. However, dinatri EDTA choice compared with dinatri EDTA-natri bisulfit combination is the same because of dinatri EDTA effect. Dinatri EDTA has better effect to the stable of pH and increase anti-bacteria effect of benzalkonium chloride
Ophthalmic Solutions ; Tobramycin ; Drug Stability

From the year 1993 to 2003, at the Hospital 19-8, 21 cases of intestinal obstruction due to food waste were treated surgery. Clinically, intestinal food waste obstruction had been moderately in progress. For diagnosis, clinics have to combine with X-ray and ultrasound. The damage was mainly seen in the intestine, but also in the stomach, and not in the colon. The operation for opening the fraction of intestine above the obstruction site for removing the food waste, then suturing immediately. This had demonstrated the effect. If the trauma was occurred late, because of the risk of rupture of the binding in the open site, the cutting-off intestine fragment was recommended.
Diagnosis ; Therapeutics ; Intestinal Obstruction

A survey was performed at the Hospital No 108 on 1200 cases of accident emergency. Result showed a higher rate of occurrence in male than in female subjects with a ratio of 1/3.The highest incident was traffic accidents,which accounted for 65%, followed by occupational, then quotidien life accidents. Motorbike had caused 70,89% of cases of traffic accidents. In all occupational accidents, the construction works had caused 71,86%. In quotidien life criminal events had caused 39,78% of cases. Traffic accidents caused primarily traumata at lower limbs-37,30%, at skull-brain area-27,18%. In occupational works, abdomen- thoracic traumata had occurred principally -52,39%. Total mortality accounted for 0,58%.
Emergencies ; Accidents ; Surgery ; Therapeutics

Biological molecular methods were used to determinate ABO genotype determination. This method allowed extract DNA from biological samples (blood, saliva, hair root) for PCR reaction. Using PCR technique and enzymes, there were 1/3 individuals that have homozygote genotypes AA, BB, OO; 2/3 were heterozygote. In addition, this method could determine samples DNA samples from blood stains, saliva stains and hair root cells... So it has very important role in medical examination.
Methods ; ABO Blood-Group System ; Molecular Biology

From January 1994 to December 2003, at the Hospital 198, 697 patients (149 males, 548 females) with simple thyroid goiter, aged 16-75 years oldwere treated and operated. The age of highest incidence was 21-40 years old (79.92%). Thyroid cyst accounts for highest incidence 48.21%. According to WHO classification the incidence of surgery was mainly in the goiter of 2nd, 3rd grade. Anapathological analysis found the highest incidence 47.92% in simple colloid goiter. There were 4 cases of thyroid cancer (0.57%). General complications found in 2.44%.
Therapeutics ; Surgery ; Goiter ; Thyroid Gland

A case of teratoma in a male patient aged 53 years old at the liver left lobe, hospitalized 25 November 2002 at The Hospital 198 was persented. It was a special form of mature teratoma of dermoid cyst. Macroscopically, it was a cyst of large size with thick fibroid shell, containing fat fluid, caseinous matter, hair, cartilaginous bone and even 3 molar teeth. Microscopically, it was a lining of cells of keratinoid epithelial scale tissue in the wall. Under the epithelial cover there was a conjunctive tissue inserted by sebacenous tissues, sweat gland tissues, hair alveoli and vessels with thick fibrous wall.
Teratoma ; Liver ; Diagnosis ; Pathology ; History

45 patients with spleen trauma were treated in the hospital No 19-8. Among then, 17 underwent a prevervative operation for suturing the spleen according to the state of trauma in site, the surgeon's qualification and the follow- up conditions. The preservative suture must be safe, spleen function must be preserved, any spleen edge could be partialy removed in case of injury. Early result can be altained in 94,11% and early post operative complication in 5,89% of cases.
Abdominal Injuries ; Surgery ; Diagnosis

The study was performed on 727 currently working and retied officials in Thai Binh province to evaluate reality of hypertension. Results: the overall percentage of hypertension was 51% and tended to increase gradually by age- groups: < 60 years of age accounted for 8.8%; 60-70 years of age 14.7%; over 70 years of age 27.5%. The rate of hypertension in males was more than females. Hypertension level 1 accounted for 25.45%, level II 15.4% and level III 10.8%. The rate of hypertensive patients with left ventricular hypertrophy was 21%, coronary insufficiency 18.59% and heart rhythm disorder 3.5%. The rate of coronary insufficiency, left ventricular hypertrophy and heart rhythm disorder in hypertension level I group were 10.8%, 4.86%, 1.6%, respectively, lower than hypertension level II group (37.8%, 47.2%, 6.8%, respectively)
Hypertension ; Epidemiology