BACKGROUND: Port wine stains (PWSs) are commonly treated with pulsed dye laser (PDL) as a standard therapy. However, it is not easy to predict the minimal effective dose in the first treatment session. OBJECTIVE: The aim of this study was to assess whether dermoscopic findings before and after laser irradiation corresponded with the clinical improvement of PWS in patients undergoing PDL therapy. METHODS: Seven untreated PWSs in 6 patients (a male and 5 females), who presented to our hospital between May 2008 to January 2010, were assessed in this study. The mean age was 36.3 years, ranging from 14 to 57 years. A PDL with a wavelength of 585 nm and a spot size of 7 mm was used. Before and after test irradiation, patients underwent dermoscopy and clinical photography, and we assessed whether the dermoscopic findings corresponded with clinical improvement after 3 months. RESULTS: There were no obvious differences observed in the clinical photographs between each test level immediately after irradiation. However, dermoscopic photographs showed differences as the irradiated energy increased. These changes corresponded to the clinical improvement after 3 months. CONCLUSION: Our study indicates that the minimal effective fluence can be predicted by observing dermoscopic change immediately after irradiation. We think that examining the dermoscopic findings immediately after irradiation allows the laser surgeon to predict the minimal effective fluence and this prevents adverse effects of the skin.
Dermoscopy ; Humans ; Lasers, Dye ; Male ; Photography ; Port-Wine Stain ; Skin

PURPOSE: To introduce a new simple technique using suture anchors and ceramic spacers to stabilize the elevated laminae in open-door cervical laminoplasty. Although ceramic spacers were placed in the opened laminae and fixed with nylon threads in this series, it was occasionally difficult to fix the nylon threads to the lateral mass. MATERIALS AND METHODS: Study 1: A preliminary study was conducted using a suture anchor system. Sixteen consecutive patients who underwent surgery for cervical myelopathy were prospectively examined. Study 2: The second study was performed prospectively to evaluate the feasibility of this new technique based on the result of the preliminary study. Clinical outcomes were examined in 45 consecutive patients [cervical spondylotic myelopathy (CSM)] and 43 consecutive patients (OPLL). The Japanese Orthopedic Association scoring system (JOA score), axial neck pain, and radiological findings were analyzed. RESULTS: 1) In one case, re-operation was necessary due to dislodgement of the ceramic spacer following rupture of the thread. 2) In all patients, postoperative CT scans showed that the anchors were securely inserted into the bone. In the CSM group, the average JOA score improved from 9.5 points preoperatively to 13.3 at follow-up (recovery 51%). In the OPLL group, the average JOA score improved from 10.1 (5-14) points preoperatively to 14.4 (11-16) at follow-up (recovery 62%). There were no serious complications. CONCLUSION: The use of the suture anchor system made it unnecessary to create a hole in the lateral mass and enabled reliable and faster fixation of the HA spacers in open-door laminoplasty.
Adult ; Aged ; *Ceramics ; Cervical Vertebrae/radiography ; Feasibility Studies ; Female ; Follow-Up Studies ; Humans ; Laminoplasty/*methods ; Male ; Middle Aged ; Postoperative Period ; Prospective Studies ; Spinal Cord Diseases/*surgery ; Suture Anchors ; *Sutures ; Tomography, X-Ray Computed ; Treatment Outcome

The purpose of this study was to investigate the relationship between toe muscular strengths and single and/or repetitive jump performances on different directions (vertical or horizontal) in athletes. Thirty two male collegiate students participated (athletes group n=24, control group n=8). Two types of measurements were performed to evaluate toe muscular strengths: toe pushing force (TPF) with the metatarsophalangeal joint (MPJ) at neutral position (0°) and the MPJ in the dorsiflexed position (45°). Jump performances were assessed by press jump (vertical jump and standing broad jump) that measures jumping height or distance, and rebound jump (rebound jump and repetitive hopping) that measures “RJ-index” (the jumping height divided by the contact time). Pearson correlation coefficients were used to determine the relationship between the toe muscular strengths and the performances of each jumping test. There were significant correlations between TPF with the MPJ in the dorsiflexed position and the performances of the repetitive hopping and rebound jump in athletes (P<0.05), but no significant correlations were found in controls. Also, there were no significant correlation between TPF and the performances of vertical jump and standing broad jump of all groups. These results suggest that, TPF in the dorsiflexed positions is one of the indicators that affect repetitive jump performance.

The anti-inflammatory and anti-oxidant effect of equine placental extract (ePE) on epidermal keratinocytes was examined. ePE reduced mRNA levels of TNF-α (Tumor Necrosis Factor-α) and IL-6 (Interleukin-6) among the inflammatory cytokines released by epidermal keratinocytes after ultraviolet light (UVB: 290-320 nm) exposure. ePE also activated Nrf2, a transcription factor known to be activated by oxidative stress to promote the expression of antioxidant enzymes and suppress inflammation, and it increased the mRNA level of the antioxidant enzyme HO-1 (Heme Oxygenase-1). These results suggest that ePE suppresses UV-induced inflammation of epidermal keratinocytes via activation of Nrf2.