OBJECTIVES: The purpose of this study was to investigate changes in public recognition of parabens on Twitter and the research status of parabens related to toothpaste. METHODS: Tweet information between 2010 and October 2016 was collected by an automatic web crawler and examined according to tweet frequency, key words (2012-October 2016), and issue tweet detection analyses to reveal changes in public recognition of parabens on Twitter. To investigate the research status of parabens related to toothpaste, queries such as “paraben,”“paraben and toxicity,”“paraben and (toothpastes or dentifrices),” and “paraben and (toothpastes or dentifrices) and toxicity” were used. RESULTS: The number of tweets concerning parabens sharply increased when parabens in toothpaste emerged as a social issue (October 2014), and decreased from 2015 onward. However, toothpaste and its related terms were continuously included in the core key words extracted from tweets from 2015. They were not included in key words before 2014, indicating that the emergence of parabens in toothpaste as a social issue plays an important role in public recognition of parabens in toothpaste. The issue tweet analysis also confirmed the change in public recognition of parabens in toothpaste. Despite the expansion of public recognition of parabens in toothpaste, there are only seven research articles on the topic in PubMed. CONCLUSIONS: The general public clearly recognized parabens in toothpaste after emergence of parabens in toothpaste as a social issue. Nevertheless, the scientific information on parabens in toothpaste is very limited, suggesting that the efforts of dental scientists are required to expand scientific knowledge related to parabens in oral hygiene measures.
Oral Hygiene ; Parabens* ; Toothpastes*

Background: Relative Dentin Abrasivity (RDA), as set by ISO 11609, is a standardized measurement on the abrasiveness of toothpaste. There are no published RDA values for Philippine-brand toothpastes. This study evaluated the degree of abrasion of five Philippine-brand toothpastes.

Objective: To compare qualitatively and quantitatively the abrasivity of five Philippine-brand toothpastes (Brands X, U, H, HN, G) to two foreign-brand toothpastes Brand C (RDA 68) and Brand P (RDA 150).

Methods: Twenty-four bovine dentin samples were brushed with a slurry of each of the toothpaste using a toothbrushing machine. A profilometer, scanning electron microscope and a visual measuring scope were used to determine abrasivity through the before-and-after-brushing surface roughness.

Results: Ranked based on the difference of the means for surface roughness, before-and-after brushing, in decreasing order of abrasivity are: Brands P, X, U, H, C, HN, and G. Using Dunn's test-post hoc test for Kruskal-Wallis test at p ? 0.05, we showed that the abrasivity of Brands G, H, and HN were not significantly different from Brand C, and Brand X was not significantly different from Brand P. Brand U was significantly less abrasive than Brand P and significantly more abrasive than Brand C.

Conclusion: Brands G, H, and HN can be considered as low-abrasive toothpastes, Brand X a high abrasive toothpaste, and with Brand U was unclear as to category. Findings from qualitative data support the quantitative data.

PURPOSE: The aim of this study was to compare the effectiveness of hydroxyapatite containing toothpaste with positive control toothpastes in reducing dentine hypersensitivity. MATERIALS AND METHODS: This clinical trial was a double-blind, randomized, parallel group comparison of two, namely hydroxyapatite containing toothpaste and strontium chloride containing toothpaste. A total of 55 subjects were included in this study. The subjects were given randomly assigned one of the two toothpastes after received tooth brushing instruction at baseline. Some clinical indices(PI, GI, PD), verbal rating score(VRS) for sensitivity to stimulus, the effect in relieving sensitivity and visual analogue scale(VAS) for sensitivity at baseline, week 2, week 4 and week 8 were assessed. All data were evaluated by intention-to-treat analysis. RESULTS: Overall, PI and GI scores were significantly reduced compare baseline in all groups(p<0.05). In addition, there was significant difference in PI at 4 weeks and in GI at 4, 8 weeks between groups. The proportions of subjects relieved sensitivity were 70.4% in experimental group and 57.1% in control group at 8 weeks respectively. The VRS for sensitivity to three kinds of stimuli and VAS for sensitivity decreased according to time, there was no overall difference between two groups(p>0.05). CONCLUSION: This study demonstrated that the new hydroxyapatite containing toothpaste was similarly effective in reducing dentine hypersensitivity with pre-existing benchmark toothpaste.
Dentin ; Dentin Sensitivity ; Durapatite ; Strontium ; Tooth ; Toothpastes

PURPOSE: The present study was performed to evaluate the effect of hydroxyapatite dental paste on tooth hypersensitivity compared to other materials. MATERIALS AND METHODS: In the general fluoride dental paste, strontium fluoride dental paste and hydroxyapatite dental paste, patient-performed VAS and VAS(ice test) were measured at baseline, 1weeks and 4weeks. RESULTS: 1. In patient-performed VAS, there were significant differences reducing of tooth hypersensitivity between general fluoride toothpaste and hydroxyapatite toothpaste. 2. In operator-performed VAS(ice test), there were significant differences reducing of tooth hypersensitivity among each group, between general fluoride toothpaste and hydroxyapatite toothpaste and between general fluoride toothpaste and strontium fluoride toothpaste. CONCLUSION: In conclusion, hydroxyapatite toothpaste can be applied for control of tooth hypersensitivity.
Durapatite ; Fluorides ; Hypersensitivity ; Strontium ; Tooth ; Toothpastes

PURPOSE: The purpose of this study was to evaluate the effects of hydroxyapatite containing toothpaste for patients who received periodontal therapy and felt hypersensiptivity. MATERIAL AND METHODS: After application of toothpaste, patients were evaluated for VAS(Visual Analog scale) scores to a cold stimulate on baseline, 1 week, and 4 weeks. VAS scores were analyzed by statistical methods. RESULTS: The results of this study were as follows. 1. VAS scores in control group on baseline, 1 week, 4 weeks were 5.39+/-2.05, 4.75+/-2.00, 4.21+/-1.75. 2. VAS scores in experimental group on baseline, 1 week, 4 weeks were 5.61+/-2.37, 4.81+/-2.46, 4.08+/-2.54. 3. Decrease of VAS scores on hypersensitivity after 1week was 0.64+/-0.49(p<.0001) in control group, 0.80+/-1.65 (p<.0001) in experimental group. 4. Decrease of VAS scores on hypersensitivity after 4weeks was 1.18+/-1.60(p<.0001) in control group, 1.53+/-1.88 (p<.0001) in experimental group. 5. When compared, decrease of VAS scores after 1 week between 2 groups were not statistically different(p=0.2622). 6. When compared, decrease of VAS scores after 4 weeks between 2 groups were not statistically different(p=0.1219). CONCLUSION: It was confirmed that hydroxyapatite containing toothpaste have the similar effect with pre-existing proven dentifrice for relieving teeth hypersensitivity.
Cold Temperature ; Dentifrices ; Durapatite ; Humans ; Hypersensitivity ; Tooth ; Toothpastes

Many researches are being done to study the effect of toothpaste containing natural extracts. The aim of this study was to evaluate the plaque control effect and therapeutic effect of toothpaste products containing chitosan extract. 120 healthy subjects with gingivitis or early periodontitis were divided into two groups. Subjects in the experimental group only used toothpaste containing chitosan and subjects in the control group used toothpaste without chitosan. At first, subjects received scaling and tooth brushing instruction. Gingival index, bleeding index, probing pocket depth, probing attachment level were scored at baseline, 2 months, and 3 months, and plaque index were scored at baseline, 1month, 2months, 3months. Gingival index of experimental group and control group at baseline, 2 months, and 3 months use were 0.71+/-0.66, 0.49+/-0.55, 0.36+/-0.49 and 0.62+/-0.58, 0.51+/-0.52, 0.48+/-0.50 (mean+/-SD), respectively (statistically significant different at p<0.05 ). Plaque index of experimental group and control group at baseline, 1 month, 2 months, and 3 months were 0.52+/-0.50, 0.43+/-0.50, 0.39+/-0.49, 0.29+/-0.46 and 0.49+/-0.50, 0.50+/-0.50, 0.51+/-0.50, 0.45+/-0.50, respectively (statistically significant different at p<0.05 ). Bleeding index of experimental group and control group were 0.40+/-0.49, 0.33+/-0.47, 0.24+/-0.43 and 0.40+/-0.49, 0.38+/-0.49, 0.30+/-0.46, respectively (statistically significant different at p<0.05 ). Probing depth of experimental group and control group were 2.41+/-0.64, 2.31+/-0.60, 2.28+/-0.55 and 2.51+/-0.67, 2.47+/-0.63, 2.42+/-0.62, respectively (statistically significant different at p<0.05 ). Attachment level of experimental group and control group were, 2.46+/-0.70, 2.36+/-0.66, 2.32+/-0.62 and 2.54+/-0.70, 2.51+/-0.69, 2.46+/-0.66, respectively (statistically significant different at p<0.05 ). From these finding, it can be concluded that toothpaste containing chitosan have better plaque control effect and therapeutic effect on gingivitis and early periodontitis compared to conventional toothpastes.
Chitosan* ; Gingivitis ; Hemorrhage ; Periodontal Index ; Periodontitis ; Tooth ; Toothpastes*

OBJECTIVES: To assess the absorption of α-tocopherol acetate and 18β-glycyrrhetinic acid, which are used as active ingredients in toothpaste, into a reconstructed gingival tissue. METHODS: EpiGingival™ tissues were treated with a 25% slurry of toothpaste containing 2% α-tocopherol acetate and 0.3% 18β-glycyrrhetinic acid, for 2 minutes. The treatment was repeated up to 6 times, with 1 hour intervals. After completion of all treatments, the active ingredients in the tissue extracts and receiver solutions were measured by high performance liquid chromatography. RESULTS: Although α-tocopherol acetate was not detected, α-tocopherol was detected in the tissue extracts, indicating that α-tocopherol acetate was bioconverted to α-tocopherol after absorption. We could detect 18β-glycyrrhetinic acid both in the tissue extracts and in the receiver solutions, with a positive correlation to the number of treatments. CONCLUSIONS: We found that our toothpaste effectively delivered α-tocopherol acetate and 18β-glycyrrhetinic acid to a reconstructed gingival tissue in vitro.
Absorption* ; Chromatography, Liquid ; In Vitro Techniques* ; Periodontal Diseases ; Tissue Extracts ; Toothpastes

OBJECTIVETo evaluate the effect of an arginine-containing antihypersensitivity polishing paste on Streptococcus mutans (S. mutans) adhesion to treated dentin.

METHODSDentin discs were treated with acid to expose dentin tubules, and then polished with either pumice or a polishing paste containing arginine. The surface roughness of the treated dentin was measured. The effects of dentin treatment on S. mutans adhesion and glucosyltransferase (GTFs) gene expression were also evaluated.

RESULTSThe surface roughness decreased after polishing with both pumice and arginine-containing polishing paste. Moreover, the polishing paste affected gtfB and gtfC expressions.

CONCLUSIONThe arginine-containing polishing paste affects S. mutans adhesion, as well as gtfB and gtfC expressions. The polishing paste may be used to prevent caries in exposed dentin areas.

OBJECTIVETo evaluate the reliability of a method of measuring the total fluoride in fluoride-containing toothpastes with acid diffusion and fluoride selective electrode.

METHODSFour brands of commercially available non-fluoride toothpastes and fluoride-containing toothpastes were sampled. Fluoride was extracted from the toothpastes in 2 mol/L HC10(4) at room temperature overnight and then subjected to the measurement with fluoride electrode.

RESULTSFluoride recovery of the non-fluoride toothpastes containing calcium as abrasive by this method was 99.5%-100.5%, more than 94% of total fluoride was measured from the marketed fluoride toothpastes, and the variation coefficient of this method was less than 1.54%. While the abrasive was silicon, the fluoride recovery of the non-fluoride toothpastes was 83.4%, and 89.7% of total fluoride was measured from the marketed fluoride-containing toothpastes.

CONCLUSIONThe amount of total fluoride in the calcium containing toothpaste can be detected simply and accurately measured by acid diffusion and fluoride selective electrode.

OBJECTIVES: To examine the tooth whitening effects of a 3% hydrogen peroxide gel.METHODS: Twenty participants were given experimental tooth whitening gels containing 3% hydrogen peroxide, and another 20 participants, who served as the control group, were given tooth whitening gels that contained no hydrogen peroxide. Both groups used their respective whitening agents for 1 week, and tooth lightness was examined at baseline and 4 and 7 days after the experiment.RESULTS: Compared with the control group, in the experimental group, lightness values, determined using VITA classical A1-D4® and VITA SYSTEM 3D-MASTER®, were significantly increased after using the 3% hydrogen peroxide whitening agent (P < 0.01) both 5 and 7 days post-application (P < 0.05).CONCLUSIONS: The study findings confirmed that an improved tooth whitening effect could be expected with the use of a new type of whitening gel containing 3% hydrogen peroxide.
Bleaching Agents ; Gels ; Hydrogen Peroxide ; Hydrogen ; Tooth Bleaching ; Tooth ; Toothpastes