Objective:To investigate the curative effect and prognostic factors of primary liver cancer(PHC) treated with radical resection combined with transcatheter arterial chemoembolization (TACE).Methods:A retrospective analysis was used to analyze the clinical data of 136 cases of PHC patients treated in Qianjiang Central Hospital of Hubei Province from January 2008 to January 2012,the 86 cases received radical resection and postoperative adjuvant TACE treatment of patients as the observation group,and the remaining 50 cases only with radical resection in the treatment of patients were selected as control group.After 6 months of treatment,the level of tumor markers Carcinoembryonic antigen(CEA),alpha fetoprotein(AFP),CA199 and alanine aminotransferase(ALT) in two groups were observed and compared.The survival status and prognostic factors of the two groups were compared.Results:After 6 months of treatment,the leve of tumor markers CEA,AFP,CA199 and ALT in the observation group were significantly lower than those in the control group(P＜0.05);The 1-year,2-year,and 3-year survival rate of the observation group were significantly higher than those in the control group;Univariate analysis showed that the differentiation degree,tumor size,lymph node metastasis,vascular tumor thrombus,CA199 concentration factors and the observation group patients (radical resection and postoperative adjuvant TACE) postoperative survival period (P＜0.05);Further multivariate analysis showed that the degree of differentiation,lymph node metastasis and CA199 concentration were the important factors influencing the prognosis of patients with TACE after radical resection (P＜0.05).Conclusion:Radical resection combined with TACE in the treatment of PHC has well clinical curative effect,which can effectively improve the postoperative long-term survival rate.Degree of differentiation,lymph node metastasis,and CA199 concentration are important factors impacting the radical resection operation adjuvant TACE prognosis.

Objective: To investigate the sexual function, urinary function and quality of life in patients of ulcerative colitis(UC) and familial adenomatous polyposis(FAP) after total proctocolectomy and ileal pouch anal anastomosis (IPAA). Methods: The clinical data of patients with UC and FAP undergoing IPAA at Zhongnan Hospital of Wuhan University from Jan 2006 to Sep 2018 were reviewed , postoperative sexual function, urinary function, and long-term quality of life were assessed. Results: There were 45 patients with median age of 35 years , median follow-up time of 31 months. 18 were UC, 27 were FAP, 5 did 1-stage surgery, 37 did 2-stage surgery, 3 for 3-stage surgery, 13 underwent open surgery, and 32 underwent laparoscopic surgery. 7 patients suffered sexual dysfunction after IPAA, and there was no statistical difference between male and female (P=0.992), UC and FAP (P=0.153), 1-stage , 2-stage , and 3-stage surgery (P=0.363) , with statistically significant difference between the open group and the laparoscopic group (P=0.025). 6 patients complicated with urinary dysfunction after IPAA , and there was no statistical difference between male and female (P=0.562), UC and FAP (P=0.325), 1-stage, 2-stage, and 3-stage surgery (P=0.286) , with statistically significant difference between the open group and the laparoscopic group (P=0.007). The Cleveland Global Quality of Life (CGQL) score after IPAA was 0.696±0.085. There were no statistical difference on CGQL scores in males and females (P=0.635), UC and FAP (P=0.664), 1-stage, 2-stage, and 3-stage (P>0.05), open group and laparoscopic group (P=0.205), postoperative long-term QOL was significantly associated only with age at the time of surgery (P=0.001). Conclusions Compared with open surgery, laparoscopic TPC-IPAA patients had better postoperative sexual function and urination function.