Objective To investigate the perioperative treatment and reduce the surgical risk in patients after pancreaticoduodenectomy (PD).Methods We retrospectively analyzed the clinical data of 213 PD patients operated at the PLA General Hospital from January 2012 to December 2012.Results The postoperative complications included pancreatic fistula (51 cases,24%),biliary fistula (8 cases,3.8%),intestinal fistula (8 cases,3.8%),gastroparesis (35 cases,16.4%),abdominal infection (16 cases,7.5%),and postoperative bleeding (16 cases,7.5%).The perioperative mortality was 1.9% (4/213).Conclusion Strengthening the perioperative management of PD patients plays an important role in improving surgical safety and reducing postoperative complications.