1.The role of tumor-associated macrophages on microvessel density after neoadjuvant chemotherapy in tongue cancer.
Bong Wook PARK ; In Kyo CHUNG ; Jong Ryoul KIM ; Uk Kyu KIM ; Bong Soo PARK ; Gyoo Cheon KIM ; June Ho BYUN
Journal of the Korean Association of Oral and Maxillofacial Surgeons 2006;32(3):209-215
r cells, and the efficacy of drug delivery can be high in richly vascularized tumors. So, this study was conducted to evaluate the effect of neoadjuvant chemotherapy on microvessel density from 11 patients with tongue cancers. Our results showed that neoadjuvant chemotherapy was seemed to decrease VEGF expression in tumor cells, however, it did not significantly alter VEGF expression in tumor-associated macrophages. Also, Neoadjuvant chemotherapy had little effect on the microvessel density using CD34, and tumor-associated macrophage level using CD68. Thus, tumorassociated macrophages seem to be the key factor associated with the maintenance of microvessel density after neoadjuvant chemotherapy in tongue cancer.
Drug Therapy*
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Humans
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Macrophages*
;
Microvessels*
;
Tongue Neoplasms*
;
Tongue*
;
Vascular Endothelial Growth Factor A
2.PHOTODYNAMIC THERAPY FOR EARLY TONGUE CANCER.
Yong Kack KIM ; Hyung Kook PARK ; Jae Hoon HYUN ; Jae Hwan KIM ; Byung Ho CHO
Journal of the Korean Association of Oral and Maxillofacial Surgeons 1998;24(2):222-225
The standard methods of treatment in oral and maxillofacial cencer are surgery, radiotherapy and chemotherapy. But all of them can induce significant morbidities, surgery in this area can cause remarkable junctional and esthetic problems. The applications of photodynamic therapy(PDT) has been studying and trying in these days to minimize post-treatment complications. It can almost directly affect tumor cells except surrounding normal tissues, so we are able to reduce post-operative complications. But there can be a couple of complications after PDT, as like skin photosensitivity, so therapists must attend to its use and completely understand their mechanism before doing it. In our clinic, PDT was tried in an early tongue cancer patient using topically applied delta-aminolaevulinic acid (delta-ALA). The 64-year-old man was gargled with 5% delta-ALA 4 hours before irradiation. The previous punched biopsy was reported as well differentiated squamous cell carcinoma(T1N0M0). Light of 635nm wave-length from argon-pumper dye laser was used. Total 150J/cm2 was applied. After 10 days, PDT was applied again in a small suspicious area, 10 days after then, small area was excised and examined histologically. It was revealed as cancer free. Now, the patient was periodically checked up. Conclusively, PDT can be thought to be a acceptable alternative and promising method in treating of early oral and maxillofacial cancer.
Biopsy
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Drug Therapy
;
Humans
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Lasers, Dye
;
Middle Aged
;
Photochemotherapy*
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Radiotherapy
;
Skin
;
Tongue Neoplasms*
;
Tongue*
3.Cordycepin, a metabolite of Cordyceps militaris, inhibits xenograft tumor growth of tongue squamous cell carcinoma in nude mice.
Qingwei ZHENG ; Yidan SHAO ; Wanting ZHENG ; Yingxu ZOU
Journal of Southern Medical University 2023;43(6):873-878
OBJECTIVE:
To evaluate the inhibitory effect of cordycepin on oral cancer xenograft in nude mice and explore the underlying mechanisms.
METHODS:
Sixteen BALB/c mice bearing subcutaneous human tongue squamous cell carcinoma (TSCC) TCA-8113 cell xenografts were randomized into model group and cordycepin treatment group for daily treatment with saline and cordycepin for 4 weeks. After the treatment, the tumor xenografts were dissected and weighed to assess the tumor inhibition rate. Histological changes in the heart, spleen, liver, kidney, and lung of the mice were evaluated with HE staining, and tumor cell apoptosis was examined using TUNEL staining; The expressions of Bax, Bcl-2, GRP78, CHOP, and caspase-12 in the xenografts were detected using RT-qPCR and Western blotting.
RESULTS:
Cordycepin treatment resulted in a tumor inhibition rate of 56.09% in the nude mouse models, induced obvious changes in tumor cell morphology and significantly enhanced apoptotic death of the tumor cells without causing pathological changes in the vital organs. Cordycepin treatment also significantly reduced Bcl-2 expression (P < 0.05) and increased Bax, GRP78, CHOP, and caspase-12 expressions at both the RNA and protein levels in the tumor tissues.
CONCLUSION
Cordycepin treatment can induce apoptotic death of TCA-8113 cell xenografts in nude mice via the endogenous mitochondrial pathway and endoplasmic reticulum stress pathways.
Humans
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Animals
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Mice
;
Carcinoma, Squamous Cell/drug therapy*
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Heterografts
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Mice, Nude
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Tongue Neoplasms/drug therapy*
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Cordyceps
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Caspase 12
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Endoplasmic Reticulum Chaperone BiP
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bcl-2-Associated X Protein
;
Tongue
4.Deep lingual arterial chemoembolization of tongue carcinoma with microcapsuled anticancer drug.
Hong HE ; Jian-qi HUANG ; Fei-yun PING ; Guan-fu CHEN ; Su-zhan ZHANG
Journal of Zhejiang University. Science. B 2007;8(10):704-708
OBJECTIVEMicrocapsule chemoembolism is a promising treatment of tumors. We describe a deep lingual arterial embolization of tongue carcinoma with microcapsuled carboplatinum.
METHODSLingual artery cast specimens from cadavers were microscopically examined, and 78 patients with tongue cancer were recruited and treated with the deep lingual arterial embolization therapy.
RESULTSMicrocapsule embolism occurred approximately at the fifth or sixth level of the deep lingual artery branches. The five-year survival rate was 88.5% (69 out of 78), and the ten-year survival rate 52.6% (41 out of 78).
CONCLUSIONThe deep lingual arterial embolization of tongue carcinoma with microcapsuled carboplatinum is an effective therapy to treat carcinoma in mid-margin or mid-body of the tongue.
Antineoplastic Agents ; administration & dosage ; Capsules ; Carboplatin ; administration & dosage ; Chemoembolization, Therapeutic ; methods ; Drug Carriers ; administration & dosage ; Humans ; Injections, Intra-Arterial ; Tongue ; drug effects ; Tongue Neoplasms ; therapy
5.Survival and Functional Outcome after Treatment for Primary Base of Tongue Cancer: A Comparison of Definitive Chemoradiotherapy versus Surgery Followed by Adjuvant Radiotherapy.
Sangjoon PARK ; Yeona CHO ; Jeongshim LEE ; Yoon Woo KOH ; Se Heon KIM ; Eun Chang CHOI ; Hye Ryun KIM ; Ki Chang KEUM ; Kyung Ran PARK ; Chang Geol LEE
Cancer Research and Treatment 2018;50(4):1214-1225
PURPOSE: The purpose of this study was to compare the clinical and functional outcomes in patients with primary base of tongue (BOT) cancer who received definitive radiotherapy (RT) or surgery followed by radiotherapy (SRT). MATERIALS AND METHODS: Between January 2002 and December 2016, 102 patients with stage I-IVB primary BOT cancer underwent either definitive RT (n=46) or SRT (n=56), and treatment outcomes were compared between two groups. The expression of p16 was also analyzed. RESULTS: The RT group had more patients with advanced T stage (T3-4) disease (58.7% vs. 35.7%, p=0.021) and who received chemotherapy (91.3% vs. 37.5%, p < 0.001) than the SRT group. At a median follow up of 36.9 months (range, 3.3 to 181.5 months), the 5-year overall survival (OS) and disease-free survival (DFS) were 75.5% and 68.7%, respectively. With respect to treatment group, the 5-year OS and DFS in the RT and SRT groups did not differ significantly (OS, 68.7% vs. 80.5%, p=0.601; DFS, 63.1% vs. 73.1%, p=0.653). In multivariate analysis, OS differed significantly according to p16 expression (p16-negative vs. p16-positive; hazard ratio [HR], 0.145; 95% confidence interval [CI], 0.025 to 0.853; p=0.033). Regarding DFS, p16 expression (p16-negative vs. p16-positive; HR, 0.164; 95% CI, 0.045 to 0.598; p=0.006) showed a significant effect in multivariate analysis. Functional defects (late grade ≥ 3 dysphagia or voice alteration) were more frequently reported in the SRT than in the RT group (16.1% vs. 2.2%, p=0.021). CONCLUSION: Despite advanced disease, patients in the RT group showed comparable survival outcomes and better functional preservation than those in the SRT group.
Chemoradiotherapy*
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Deglutition Disorders
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Disease-Free Survival
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Drug Therapy
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Follow-Up Studies
;
Humans
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Multivariate Analysis
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Organ Preservation
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Radiotherapy
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Radiotherapy, Adjuvant*
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Tongue Neoplasms*
;
Tongue*
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Treatment Outcome
;
Voice
6.Modulation of Chinese regimen granules of Shenyang on peripheral blood lymphocyte subsets of SD rats with SCC of tongue.
Can-hua JIANG ; Dong-xia YE ; Wan-tao CHEN ; Xiu-li ZHANG ; Zhi-yuan ZHANG ; Wei-liu QIU
Chinese Journal of Stomatology 2005;40(2):118-121
OBJECTIVEProspective research demonstrated that Chinese regimen granules of Shenyang could prolong survival time and improve survival rate of patients with oral squamous cell carcinoma (SCC). But the mechanism was not clear. The purpose of this study was to investigate Shenyang's effect on peripheral blood lymphocyte subsets of SD rats with SCC of tongue and explore immunological mechanism.
METHODSAmong 80 SD rats fed by 0.002% 4-nitroquinoline-1-oxide (4NQO) drinking water for 36 weeks, 61 rats with SCC of tongue had been found and were randomly divided into 4 groups, namely Shenyang A, Shenyang B, positive and blank control groups. Before and after high and normal dosage of Shenyang, acanthopanax senticoside and water had been given for 15 days respectively, peripheral blood lymphocyte subsets were detected with flow cytometry. The data were statistically analyzed with paired t Test.
RESULTSPercentage of CD3+ CD4+ T cell and CD3-CD161a+ NK cell, ratio of CD4+/CD8+ were increased. Percentage of CD3+CD8+ T cell was decreased, and the effect was better than that of acanthopanax senticoside in improving the percentage of CD3-CD161a+ NK cell.
CONCLUSIONAmong anti-tumor mechanisms of Shenyang it is that corrects disorder of lymphocyte subsets and increases percentage of CD3-CD161a+ NK cell.
Animals ; Carcinoma, Squamous Cell ; drug therapy ; immunology ; Drugs, Chinese Herbal ; pharmacology ; Female ; Lymphocyte Subsets ; drug effects ; immunology ; Rats ; Rats, Sprague-Dawley ; Tongue Neoplasms ; drug therapy ; immunology
7.Study on drug release after arterial embolism with cisplain-loaded albumin microspheres in treating carcinoma of tongue.
Hongwei LI ; Yuming WEN ; Changmei WANG
West China Journal of Stomatology 2003;21(2):112-139
OBJECTIVEThe purpose of this study was to investigate the cisplatin release in peripheral blood and tumor tissue after cisplatin-loaded albumin microspheres (CDDP-AMS) were infused through lingual artery for treating carcinoma of tongue.
METHODSAnticancer agent cisplatin was encapsulated with biodegradable and non-antigenic albumin. The cisplatin-loaded albumin microspheres, which were 56.3 microns in diameter, were used for treating 7 patients with squamous carcinoma of tongue by infusing through lingual artery. The cisplatin in peripheral venous blood and carcinoma tissue were measured for analyzing the drug release in vivo.
RESULTSConcentration of the drug in peripheral venous blood increased to the highest level in 90 minutes after CDDP-AMS was infused through lingual arterial and still could be detected until 10th day. The cisplatin concentration in tumor tissue kept considerably stable and could be detected until 17 days.
CONCLUSIONCDDP-AMS had the effect of controlled release in vive. Effective and steady local drug concentration played the role of killing tumor cells, the low concentration in peripheral blood reduced the side effects of cisplatin to minimum as well. It is concluded that CDDP-AMS is a useful and recommendable method for treating the carcinoma of tongue.
Adult ; Aged ; Albumins ; Antineoplastic Agents ; administration & dosage ; blood ; Arteries ; Carcinoma, Squamous Cell ; drug therapy ; Cisplatin ; administration & dosage ; blood ; Delayed-Action Preparations ; Drug Carriers ; Female ; Humans ; Infusions, Intra-Arterial ; Male ; Microspheres ; Middle Aged ; Tongue ; blood supply ; Tongue Neoplasms ; drug therapy
8.Objective tongue inspection on 142 liver cancer patients with damp-heat syndrome.
Yue CHEN ; Ting-hui JIANG ; Wei-zhe RU ; Ai-wu MAO ; Yan LIU
Chinese journal of integrative medicine 2014;20(8):585-590
OBJECTIVETo establish the diagnosis evidence of objective tongue inspection for liver cancer (LC) patients with damp-heat syndrome (DHS) by dynamically observing their tongue figures using modern tongue image analytic apparatus, and to explore the effect of intervention on the tongue figures.
METHODSTongue figures were collected from 142 LC patients with DHS by tongue image analytic apparatus. Red (R), green (G) and blue (B) values were analyzed. The r and g values were calculated requesting r=R/(R+G+B), g=G/(R+G+B), and b=1-r-g, and scored in combination with Chinese medical symptoms scale. The tongue figure and correlated scores were collected from 59 of them 3 days after transcatheter arterial chemoembolization intervention.
RESULTSThe range of objective tongue inspection of LC patients with DHS was as follows: as for tongue fur, 0.360
CONCLUSIONThe range of objective tongue inspection of LC patients with DHS could be known by collecting and analyzing objective indicator of tongue figures, thus laying foundation for further studies with analysis of correlation between intervention and Chinese medicine based on tongue figures.
Hot Temperature ; Humans ; Image Processing, Computer-Assisted ; Liver Neoplasms ; diagnosis ; drug therapy ; Middle Aged ; Observation ; Syndrome ; Tongue ; pathology
9.Dysphagia in Tongue Cancer Patients.
Yu Ri SON ; Kyoung Hyo CHOI ; Tae Gyun KIM
Annals of Rehabilitation Medicine 2015;39(2):210-217
OBJECTIVE: To identify risk factors for dysphagia in tongue cancer patients. Dysphagia is a common complication of surgery, radiotherapy, and chemotherapy in tongue cancer patients. Previous studies have attempted to identify risk factors for dysphagia in patients with head and neck cancer, but no studies have focused specifically on tongue cancer patients. METHODS: This study was conducted on 133 patients who were diagnosed with tongue cancer and who underwent a videofluoroscopy swallowing study (VFSS) between January 2007 and June 2012 at the Asan Medical Center. Data collected from the VFSS were analyzed retrospectively. Patients with aspiration were identified. RESULTS: Patients showed a higher incidence of inadequate tongue control, inadequate chewing, delayed oral transit time, aspiration or penetration, vallecular pouch and pyriform residue, and inadequate laryngeal elevation after surgery. Moreover, male gender, extensive tumor resection, a higher node stage, and more extensive lymph node dissection were major risk factors for aspiration in tongue cancer patients. CONCLUSION: Tongue cancer patients have difficulties in the pharyngeal phase as well as the oral phase of swallowing. These difficulties can worsen after tongue cancer surgery. Gender, the extent of tumor resection, and lymph node metastasis affect swallowing in tongue cancer patients. Physicians should take these risk factors into account when administering swallowing therapy to tongue cancer patients.
Chungcheongnam-do
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Deglutition
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Deglutition Disorders*
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Drug Therapy
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Head and Neck Neoplasms
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Humans
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Incidence
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Lymph Node Excision
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Lymph Nodes
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Male
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Mastication
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Neoplasm Metastasis
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Radiotherapy
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Retrospective Studies
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Risk Factors
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Tongue
;
Tongue Neoplasms*
10.Skeletal Muscle Metastasis and Elevated beta-HCG Level Secondary to Tongue Cancer: a Case Report and Review of Literature.
Jun Soo HAM ; Keum Bit HWANG ; Subin HWANG ; Suk Hyeon JEONG ; Ji Yun LEE ; Se Hoon LEE ; Keunchil PARK
Korean Journal of Medicine 2015;89(6):719-722
Metastases to skeletal muscle and paraneoplastic syndromes involving beta-human chorionic gonadotropin (HCG) production are an extremely rare manifestation of head and neck squamous cell carcinoma. We report a patient with a beta-HCG-secreting squamous cell carcinoma of the tongue with diffuse metastases involving skeletal muscle. A 47 year old female, who was being treated heavily with palliative chemotherapy for metastatic tongue cancer, was admitted with a palpable thigh mass and pain. A magnetic resonance image showed an intramuscular metastasis in the thigh. Ultrasound-guided biopsy of the thigh mass confirmed metastatic squamous cell carcinoma. She was scheduled for enrollment into a clinical trial; however, a positive serum beta-HCG test was noticed. There was no evidence of pregnancy or a trophoblastic or non-trophoblastic tumor secreting beta-HCG. Finally, she was revealed to have a paraneoplastic syndrome with diffuse metastases and was ultimately referred for palliative care. We review the literature of previously reported cases of an increase of beta-HCG in patients with head and neck cancer.
Biopsy
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Carcinoma, Squamous Cell
;
Chorionic Gonadotropin
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Chorionic Gonadotropin, beta Subunit, Human
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Drug Therapy
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Female
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Head
;
Head and Neck Neoplasms
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Humans
;
Muscle, Skeletal*
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Neck
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Neoplasm Metastasis*
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Palliative Care
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Paraneoplastic Syndromes
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Pregnancy
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Thigh
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Tongue Neoplasms*
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Tongue*
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Trophoblasts