1.High quality reconstruction algorithm for cardiac magnetic resonance images based on multiscale low rank modeling.
Yang HENG ; Feng CHEN ; Jianfeng XU ; Min TANG
Journal of Biomedical Engineering 2019;36(4):573-580
Taking advantages of the sparsity or compressibility inherent in real world signals, compressed sensing (CS) can collect compressed data at the sampling rate much lower than that needed in Shannon's theorem. The combination of CS and low rank modeling is used to medical imaging techniques to increase the scanning speed of cardiac magnetic resonance (CMR), alleviate the patients' suffering and improve the images quality. The alternating direction method of multipliers (ADMM) algorithm is proposed for multiscale low rank matrix decomposition of CMR images. The algorithm performance is evaluated quantitatively by the peak signal to noise ratio (PSNR) and relative norm error (RLNE), with the human visual system and the local region magnification as the qualitative comparison. Compared to L + S, kt FOCUSS, k-t SPARSE SENSE algorithms, experimental results demonstrate that the proposed algorithm can achieve the best performance indices, and maintain the most detail features and edge contours. The proposed algorithm can encourage the development of fast imaging techniques, and improve the diagnoses values of CMR in clinical applications.
Algorithms
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Heart
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diagnostic imaging
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Humans
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Magnetic Resonance Imaging
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Signal-To-Noise Ratio
2.Design, synthesis, and biological evaluation of multiple targeting antimalarials.
Yiqing YANG ; Tongke TANG ; Xiaolu LI ; Thomas MICHEL ; Liqin LING ; Zhenghui HUANG ; Maruthi MULAKA ; Yue WU ; Hongying GAO ; Liguo WANG ; Jing ZHOU ; Brigitte MEUNIER ; Hangjun KE ; Lubin JIANG ; Yu RAO
Acta Pharmaceutica Sinica B 2021;11(9):2900-2913
Malaria still threatens global health seriously today. While the current discoveries of antimalarials are almost totally focused on single mode-of-action inhibitors, multi-targeting inhibitors are highly desired to overcome the increasingly serious drug resistance. Here, we performed a structure-based drug design on mitochondrial respiratory chain of