Objective To explore the clinical therapeutic effects of visual cystoscope combined with ureteroscope in the treatment of closed posterior urethral injury. Methods A total of 68 patients with closed posterior urethral injury who were admitted to inpatient department from September 2008 to September 2013 were compared and studied clinically. They were assigned to two groups according to different treatment approaches, with 34 patients in each group. The con-trol group received the operation under ureteroscope, while the research group received the operation under visual cys-toscope combined with ureteroscope. Clinical efficacy and safety between the two groups of patients were analyzed and summarized. Results Surgical time, bleeding volume during surgery, hospitalization time, scores of CPSI-U, residual urine volume, urine flow rate and life quality index in the two groups were compared, and the differences were signifi-cant (t=3.89, 3.62, 2.88, 9.16, 16.16, 15.88 and 15.01 respectively, P<0.05). Total rate of complications in the two groups was compared, and the difference was significant (χ2=12.93, P<0.05). Conclusion Visual cystoscope combined with ureteroscope in the treatment of closed posterior urethral injury has a magnificent curative effect, and shows its edges of minimal invasion, short surgical time, rapid recovery and low rate of complications, which is safe, effective and has a great clinical value.