Objective To discuss the effect of whole course comprehensive nursing intervention on postoperative pain of patients with joint replacement.Methods 116 cases who had joint replacement were randomly divided into the control group (n =57) and the intervention group (n =59).Both groups received conventional nursing before and after surgeries,and the intervention group received whole course comprehensive nursing intervention in addition,which included preoperative nursing intervention according to patient' s social background,standard of culture and psychological quality,whole course accompany during surgery,postoperative pain nursing intervention and follow-up after discharge.Intervention effect was compared between two groups.Results Pain degree was lower in the intervention group than in the control group.Pain score 8 hours after operation was (6.54 ± 1.65) in the intervention group and (9.63 ± 1.73) in the control group,and the difference was statistically significant (t =9.84,P ＜ 0.01).The first leaving bed time was (13.62 ± 4.28) h in the intervention group and (19.83 ±5.27) in the control group,hospitalization time was (14.17 ±2.43) d in the intervention group and (17.67 ± 3.51)d in the control group,treatment cost was (17.67 ± 3.51) yuan in the intervention group and (7 581.38 ± 55.24) yuan in the control group,and the differences were statistically significant (t =6.95,6.22,183.64,respectively ; P ＜ 0.01).Score of life quality was (5.92 ± 0.33) in the intervention group and (3.78 ± 0.25) in the control group,and the difference was statistically significant (t =39.45,P ＜ 0.01).Conclusions The implementation of whole course comprehensive nursing intervention for joint replacement patients can effectively relieve their postoperative pain,enhanced their pain tolerance,improve their comfort,quality of life and sleep quality,reduce postoperative complications,shorten average hospital stay,and raise their satisfaction and treatment effect,thereby improving the quality of holistic nursing care.

BACKGROUNDGenome-wide association studies for type 2 diabetes mellitus (T2DM) identified FTO gene as a locus conferring increased risk for common obesity in many populations with European ancestry. However, the involvement of FTO gene in obesity or T2DM related metabolic traits has not been consistently established in Chinese populations. The objective of this study was to investigate the association of FTO genetic polymorphisms with metabolic syndrome (MetS) in Han Chinese.

METHODSWe tested 41 FTO single nucleotide polymorphisms (SNPs) for association between FTO and MetS-related traits. There were a total of 236 unrelated subjects (108 cases and 128 controls), grouped according to the International Diabetes Federation (IDF) criteria.

RESULTSOf the 41 SNPs examined, only SNP rs8047395 exhibited statistical significance (P = 0.026) under a recessive model, after Bonferroni adjustment for multiple testing (OR 1.64, 95%CI 1.11-2.42; P = 0.014). The common distributions of this polymorphism among Chinese--with a minor allele frequency (MAF) of 36% in the control group versus 48% in the MetS group--greatly improved our test power in a relatively small sample size for an association study. Previously identified obesity- (or T2DM-) associated FTO SNPs were less common in Han Chinese and were not associated with MetS in this study. No significant associations were found between our FTO SNPs and any endophenotypes of MetS.

CONCLUSIONSA more common risk-conferring variant of FTO for MetS was identified in Han Chinese. Our study substantiated that genetic variations in FTO locus are involved in the pathogenesis of MetS.

Alpha-Ketoglutarate-Dependent Dioxygenase FTO ; Asian Continental Ancestry Group ; Female ; Genetic Predisposition to Disease ; genetics ; Genetic Variation ; genetics ; Genotype ; Haplotypes ; genetics ; Humans ; Male ; Metabolic Syndrome ; genetics ; Middle Aged ; Polymorphism, Single Nucleotide ; genetics ; Proteins ; genetics