Experimental retinal detachment was attempted in albino rabbits by the injection of hyaluronidase (2 TRU) between the retina and vitreous body. Retinal detachment was successfully induced in 12 eyes(62.5%) after 1-4 days. Hyaluronidase injection combined with mechanical injuries of the retina produced retinal detachment in 5 eyes(60.0%). When the retinal detachment was produced, amplitudes of the a- and b-waves decreased, maximum reduction being 41.6%(a-wave) and 34.5%(b-wave). Ten to 14 days after the treatment ERG waves began to increase gradually. ERG waves rose slightly in cases in which no detachment had been successfully produced.
Hyaluronoglucosaminidase ; Rabbits* ; Retina ; Retinal Detachment* ; Retinaldehyde* ; Vitreous Body