1.Expression level and significance of TGF-β1 and CTGF in cerebrospinal fluid of patients with subarachnoid hemorrhage
Journal of Chinese Physician 2008;10(4):439-440
Objective To explore the expression and significance of TGF-β1 and CTGF in the occurrence and development of patients with subarachnoid hemorrhage. Methods Cerebrospinal fluid TGF-β1 and CTGF concentrations in all subjects were serially detected by ELISA. Results Mean total TGF-β1 and CTGF in patients were elevated more than that in controls at the first day(P<0.05).Thereafter the levels of TGF-β1 and CTGF fell by the third day, then rose to the second peak at the tenth day and remained significantly increase until the sixteenth day(P<0.05).The levels of TGF-β1 was positive correlated CTGF. Conclusion The expressions of TGF-β1 and CTGF in patients with subarachnoid hemorrhage showed two peaks character. After SAH, the concentration of TGF-β1 and CTGF concentration is related to chronic communicating hydrocephalus.
2.Sister chromatid exchanges(SCE), chromosomal aberrations and micronuclei of cultured peripheral lymphocytes in miners, nonmining workers of Dachang Tin Mine in Guangxi
Chinese Journal of Pathophysiology 1986;0(03):-
Determination of SCE frequency, chromosomal aberration and micronucleus rate of cultured peripheral lymphocytes of 38 miners who worked in the well, and 40 non-miners who worked outside the well in Dachang Area and 27 other workers who didn't work and live there (as control group) was carried out. The result showed that the miners had higher SCE incidence and chromosomal aberration rate. The nonmining workers and the control group had much lower rates. There was a significant difference between the miners and non-miners or control group, but no statistically differences were found between the non-miners and the control group. Micronucleus rate among the miners, the non-miners and the control group were all the same level statistically. We proposed that some toxic substances in the Dachang Tin Mine might be respousible for the genetic damages in the miners. We suggested that a combined assay of SCE with chromosomal aberration or micronucleus might be a good screening method for the high risk population such as the miners in Dachang Tin Mine.
3.Preliminary Study of A Volume-depending Staging System for ONFH Based on Three-dimensional CT
Journal of Zhejiang Chinese Medical University 2014;(11):1311-1314
Objective]To establish a new volume-depending staging system for ONFH through an analysis software developed by ourselves, referring to Ficat staging system. [Method]With the help of the necrosis score calculated by our software, a new 0~6 volume-depending staging system for ONFH was established referring to Ficat staging system. The correlation analysis was conducted between the Ficat stages and necrosis scores of 22 ONFH cases. [Result]According to Ficat staging system, there were 4 stage Ⅰ, 2 stage Ⅱa, 3 stage Ⅱb, 9 stage Ⅲ, 4 stage Ⅳ. According to the volume-depending staging system, there were 4 cases of stage 1, 3 stage 2, 2 stage 3, 3 stage 4, 5 stage 5, 5 stage 6. A strong linear correlation was observed between the necrosis scores of volume-depending staging system and Ficat staging system(r=0.976,P<0.01). [Conclusion]The new volume-depending staging system might be accurate and feasible. It could indicate the whole condition of ONFH more objective than Ficat staging system, which would be helpful for early diagnosis of ONFH.
4.Clinical application of atomoxetine in children with attention deficit hyperactivity disorder
Journal of Clinical Pediatrics 2009;(11):1093-1094,1100
Atomoxetine as a nonstimulant medicine was approved by the Chinese Food an Drug Administration and provide a new selection of treatment drugs for attention deficit hyperactivity disorder (ADHD). Tomoxetine is a noradrenaline transmitter reuptake inhibitor which can selectively inhibit synapsis noradrenaline transport protein, strengthen noradrenaline's resupination effect, and increase noradrenaline's activity released by synaptic cleft to improve the symptoms of the ADHD patients. Compared with methylphenidate, atomoxetine does not affect the concentration of the neurotransmitter dopamine and does not induce or increase the Tourettes' syndrome, therefore atomoxetine is more suitable to treat ADHD together with Tourettes syndrome. In this article the treatment of atomoxetine for ADHD, including the indications, dosage as well as adverse reactions and efficacy assessment are reviewed.
5.Influence of Bioethics in Medical Education
Chinese Medical Ethics 1996;0(01):-
Higher medical education should bring the superiority of the course into play,and develop the bioethics education effectively.We should arouse medical undergraduate's respect and enthusiasm for bioethics,help them reevaluate their value concept and learn to use basic theory of bioethics to guide the medical service.Thus medical science can develop in a healthy way.
6.Advance in Metabolism of n-Alkane and Metabolic Engineering of Candida tropicalis
Microbiology 1992;0(02):-
Metabolism of n-alkane mainly includes ?-oxidation pathway and ?-oxidation pathway in Candida tropicalis,which are both catalyzed by a series of enzymes. The transformation from n-alkane to fatty acid is accomplished via ?-oxidation pathway,and the degradation of fatty acid is involved in ?-oxidation pathway. The mechanism on metabolism of n-alkane and studies on related enzymes are summarized in the review. Furthermore,some molecular genetics and metabolic engineering techniques related to Candida tropicalis developed in recent years are introduced.
7.ACTIVITY ASSAY OF ACYL COENZYME A OXIDASE(ACO) FROM CANDIDA TROPICALIS
Jing OUYANG ; Yuan-Tong CHEN ;
Microbiology 1992;0(05):-
Acyl Coenzyme A Oxidase(ACO) is the rate-limiting enzyme of the ?-oxidation of dicarboxylic acid in Candida tropicalis . Using strains with low Acyl Coenzyme A Oxidase activity to produce dicarboxylic acid on an industrial scale will facilitates the improvement of the yield and purity of dicarboxylic acid. In this research, we improved the method of Allain, so as to determine the activity of Acyl Coenzyme A Oxidase from Candida tropicalis easily and correctly. This method can be used as quantity criterion in the screen of industrial strains of dicarboxylic acid production, and this work established the basic of character study of Acyl Coenzyme A Oxidase. We determined the activities of Acyl Coenzyme A Oxidase from a series of Candida tropicalis strains with different ability of dicarboxylic acid production, and found the obvious relationship of ACO activity and ability of acid production.
8.Progress of research on hand hygiene and hospital infection
Qiaojing TONG ; Guanguan SU ; Yuhua YUAN
Chinese Journal of Hospital Administration 1996;0(04):-
The germs on the hands of medical personnel in medical institutions have become the chief pathogens for hospital infection. These pathogens can be acquired not only from infected wounds or drainage wounds but also from normal and whole skin regions. Hand washing and disinfection is one of the most important measures for preventing hospital infection. The paper describes the definitions of hand washing, hygienic hand disinfection and surgical hand disinfection and discusses the action mechanisms, effects and features of various hand hygiene products currently in use, such as alcohol, hibitane glucose saline and hexachlorophenol. It enumerates a number of problems inhand hygiene, including low rate of hand hygiene observance on the part of medical personel, insufficient attention to hand hygiene on the part of medical institutions, reduction of germs' sensitivity to disinfectants, and the occurrence of contact dermatitis in disinfectant usage. The paper also gives an account of some of the latest strategies and countermeasures aiming at improving the status of hand hygiene, These include ways of lowering the incidence of contact dermatitis, reducing the bad effects of germicides, and raising the rate of hand hygiene observance.
9.Advances in Studies on Serum Biomarkers and Susceptibility Genes in Differential Diagnosis of Inflammatory Bowel Disease
Yuan CAO ; Jinlu TONG ; Zhihua RAN
Chinese Journal of Gastroenterology 2014;(5):297-300
Inflammatory bowel disease (IBD)includes Crohn’s disease (CD)and ulcerative colitis (UC).The differential diagnosis between CD and UC mainly depends on clinical symptoms,endoscopy,pathological biopsy,laboratory and imaging examinations.In recent years,studies with a variety of IBD-related biomarkers develop rapidly because of its non-invasiveness,simple and easily acceptable.With the development of genome-wide association study (GWAS),great progress has been achieved in studies of gene mutations and susceptibility genes related with CD and UC,which provides new approach for diagnosis of the disease.This article reviewed the advances in studies on serum biomarkers and susceptibility genes in differential diagnosis of IBD.
10.The Genotoxicity Research of Huainan Reach Water of the Huaihe River
Guoli LIU ; Yuan TONG ; Zhi PENG
Journal of Environment and Health 1989;0(06):-
upper and they were all higher compared with the control (P