The incidence of gastric carcinoma is increasing and lymphatic metastasis is one of the major causes of death.Vascular endothelial growth factor-C(VEGF-C),Vascular endothelial growth factor D(VEGF-D)linking their receptor(VEGFR-3)can increase lymphangiogenesis,advance lymphatic metastasis,and relate to lymphatic vessel density of tumor.More and more studies of lymphatic vessel of gastric carcinoma cause great attention.We summarizeed the mechanism of lymphangiogenesis,the new development of relationship between lymphangiogenesis and lymphatic vessel density and their clinical significance.

Objective To explore the situation and the impact of early postnatal sucking and health educa-tion on early maternal lactation physical rehabilitation of primipara.Methods 100 primiparas were randomly divided into two groups,50 cases in each group.The control group received routine care,the observation group was given suck and health care education on the basis of the control group.The maternal lactation and physical rehabilitation was compared between the two groups.Results The good rate of the maternal health knowledge in the observation group was 92.00%,the good rate of ability of nursing master was 86.00%,the lactation time was (16.46 ±2.43)h,which were significantly better than the control group(χ2 =14.03,14.89,t =10.22,all P <0.05).The postpartum rehabil-itations of the observation group were better than those of the control group(t =3.86,4.42,4.68,5.67,677,5.46, 571,4.27,3.98,508,all P <0.05).The incidence rate of complication of the observation group was 6.00%,which was significantly lower than 22.00% of the control group(χ2 =5.24,P <0.05).Conclusion First mothers receive early postnatal sucking and health education can increase their milk production capacity,promote physical rehabilitation.

Objective To observe the therapeutic effect of the integration of Longji-Huoluo pill and mild manipulations Tuina therapy for the teenagers with lumbar intervertebral disc protrusion. Methods Eligible teenager patients with lumber intervertebral disc protrusion were randomly classified into two groups according to the single blind method and the treating sequence, 69 patients in the treatment group and 58 patients in the control group. The Longji-Huoluo pill and mild Tuina manipulations were adopted on the basis of the convertional treatment in the treatment group. While ibuprofen sustained release capsules and mecobalamin were given to the control group beside the convertional treatment. Both groups were treated for 4 weeks. The CT examinations were applied before and after the treatments to observe the absorption of the prolapsed lumber intervertebral disc. The Visual Analogue Scale (VAS) was used to test the pain degree and to estimate the clinical effect. Results The VAS scores in the treatment group (4.03 ± 1.67 vs. 5.41 ± 1.55, t=10.121) and the control group (3.61 ± 1.34 vs. 5.96 ± 1.71, t=11.086) after treatment were significantly lower than those before treatment (P<0.05). The sagittal diameters of the prominence in the treatment group (2.12 ± 1.89 mm vs. 4.62 ± 0.34 mm, t=2.281) after treatmentwas significantly lower than that before treatment (P<0.05). The total effective rate of the treatment group was 87.0%(60/69), and the control group was 72.4%(42/58). Statistical significance was detected on the difference of the two groups (U=1.913, P=0.043). Conclusions The integration of manipulations can effectively relieve the pain and can return the prominent disc. The therapeutic effect is considered equivalent to western medicine.

Abstract: Objective To summary and analyze the epidemic situation of imported malaria and the prevention and control measures implemented during the new crown pneumonia epidemic in Shenzhen, so as to provide reference for the prevention and control of imported malaria under COVID-19 epidemic. Methods　The data on the prevention and control of malaria epidemic in Shenzhen from 2017 to 2021 were collected for analyzing the epidemic situation of malaria, measures taken and the effect of prevention and control with descriptive epidemiological methods. Results　From 2017 to 2021, a total of 104 confirmed malaria cases were reported in Shenzhen, all of which were imported from abroad. 97.1% were imported from Africa, mainly falciparum malaria, accounting for 80.8%. The age of onset was mainly young adults, the age group 20-49 years accounted for 81.7%, and most of the patients were overseas migrant workers, accounting for 59.6%. Imported malaria cases were reported in each month, the most was 13 cases in July, then 12 cases in September. From 2017 to 2021, 709 mosquito trap lamps were placed, and 3 523 mosquitoes were captured, with an average mosquito density of 2.60 per lamp and night. Anopheles were not found, and the dominant species were Culex quinquefasciatus. During the outbreak of COVID-19, Shenzhen has implemented a series of measures in terms of improving the working mechanism of multi-departmental cooperation and joint defense, strengthening screening and monitoring, personnel training, mosquito vector control, and material security, so as to achieve early detection, early transfer, early isolation and early treatment. Conclusions　A series of measures have been comprehensively implemented to prevent and control imported malaria in Shenzhen while preventing and controlling imported new coronary pneumonia, and achieved positive results. It has realized the timely identification of cases and effective treatment, and prevented the occurrence of severe and fatal malaria cases, as well as halting the spread and spread of malaria outbreaks.

Child ; Chromobacterium ; Female ; Humans ; Sepsis ; drug therapy ; etiology ; microbiology ; mortality

Objective To introduce the Chinese version of short Falls Efficacy Scale International (short FES-I) and test its reliability and validity in patients with cerebral infarction. Methods The English version and the traditional Chinese version of short FES-I were ob-tained from the Prevention of Falls Network Europe, and the simplified Chinese version was developed after a further revision. A sample of 105 inpatients with cerebral infarction from December 2014 to May 2015 were recruited from 2 tertiary hospitals in Tianjin. They were in-vestigated with the simplified Chinese version of short FES-I, modified Falls Efficacy Scale (MFES), Generalized Anxiety Disorder-7 (GAD-7) and Patient Health Questionnaire-9 (PHQ-9). At the same time, the laboratory indexes of the patients were collected. Results The Cronbach'sαcoefficient of short FES-I was 0.98 and the score of short FES-I was negatively correlated with MFES (r=-0.41, P<0.001). Short FES-I was correlated wtih GAD-7 score (r=0.52, P<0.001), PHQ-9 score (r=0.46, P<0.001) and the level of C reaction protein (r=0.21, P=0.032), but uncorrelated with other laboratory indexes (P>0.05). There was significant difference in the score of short FES-I be-tween the patients with or without falling. Conclusion Short FES-I is valid and internal consistant, and can be used as an assessment tool to screen fear of falling among patients with cerebral infarction.

Objective To investigate whether a novel mucosal adjuvant (DNA containing six base pair motifs consisting of an unmethylated CpG dinucleotide flanked by two 5′ purines and two 3′ pyrimidines, CpG Oligodeoxynucleotide, CpG ODN),which has not been shown to have significant toxicity,could be an ideal mucosal adjuvant for the development of a H. pylori vaccine in mice model. Methods C57BL/6 mice were orally or intranasally immunized with H. pylori whole cell sonicate(WCS) / cholera toxin (CT) or WCS /CpG ODN, and the corresponding control groups were set. Mice were dosed once a week for four weeks. One week after the last immunization, all animals were challenged by live H. pylori (5?10 8) three times in a five day duration. Two and 8 weeks after the last challenge, all animals were sacrificed to examine infection of H. pylori. Sera, saliva, gastric juice were collected to measure the concentrations of IgG, IgG1, IgG2a and IgA by ELISA. Results The protecting rates against H. pylori infection were 75%(9/12), 70% (7/10) and 0 (0/10) in the group of WCS/CT orally, WCS/CpG ODN intranasally and WCS/CpG ODN orally, respectively. Significantly higher levels of serum IgG2a antibody was found in the group immunized with WCS plus CpG ODN than those found in the sham immunized controls ( P

Objective To explore the clinical results of minimally invasive therapy for femoral intertrochanteric fractures with proximal femoral nail anti-rotation(PFNA) in 25 elderly patients.Methods A total of 25 patients with intertrochanteric fractures were treated by PFNA in our hospital from February 2007 to June 2008.The patients received close reduction and minimal invasive operation.Based upon the Tronzo-Evans classification,type Ⅰ fractures were diagnosed in 2 cases,type Ⅱ fractures in 2 cases,type Ⅲ in 16,and type Ⅳ in 5.Results The mean operation time in this series was 50.3 min(30-70 min),an the mean intraoperative blood loss was 100.2 ml(70-200 ml).All the 25 patients completed a follow-up of 3 to 12 months(average time 7.1 months),during which all the fractures healed in 10 to 14 weeks with a mean of 11 weeks,without occurrence of varus deformity,hardware loosening or hardware cutting.According to the Harris Hip Score,20 cases achieved excellent results,4 were good,and 1 was fair. Conclusions It is a reliable and ideal method to treat intertrochanteric fractures with PFNA in elderly patients,for the procedure is convenient and minimally invasive,resulting in firm fixation,less blood loss,short operation time,and high healing rate.

Objective To investigate the molecular mechanism of Helicobacter pylori (H.pylori) resistance to clarithromycin. Methods The E test was used to determine clarithromycin resistant strains of H.pylori , and PCR Restriction Fragment Length Polymorphism (RFLP) analysis for 23S rRNA domain V gene mutations. Results Of nine clarithromycin resistant stains of H.pylori , including six primary and three acquired resistant strains, eight were found to have an A to G mutation in 23S rRNA domain V at position 2144. Conclusions The results indicated that the majority (88.8%) of clarithromycin resistant isolates of H.pylori in Shanghai have an A2144G mutation in 23S rRNA domain V.

Objective To compare the effects of oral Sildenafil(SIL)and intravenous prostaglandin E_1(Alprostadil,PGE_1)in treatment of postoperative pulmonary hypertension(PH)associated with congenital heart defects(CHD).Methods Data were collected from 24 children with postoperative mPAP≥35 mmHg in our hospital between August 2004 and March 2005.These children were randomly divided into three groups:8 children(group A)initially received SIL(0.35 mg/kg,orally by nasal gastric tube),followed by the addition of intravenous PGE_1(20 ng/kg per min)at 40 min.The second group of 8 children(group C)initially received intravenous PGE_1 followed by the addition of SIL at 20 min(dose as above).And remains(group B)were placebo-controlled.The changes of hemodynamic variables,arterial blood gas,lung static compliance(C)and work of breathing(W)were measured after drugs were given.Results Compared with group B,the mPAP and mPAP/mSAP was significantly reduced(P