1.Evaluation of hypothermic neonates: a risk factor for death in a regional hospital for mother and neonate in Morocco
Tomoyuki KOBAYASHI ; Sami. GHITA ; E. AMINA
Journal of International Health 2010;25(3):155-160
Objectives
The objective of this study is to find the easily measurable associated factor for hypothermic neonatal mortality in a regional Moroccan hospital.
Methods
A retrospective study was carried out in PAGNON hospital. 52 patients admitted to PAGNON hospital neonatal unit for hypothermia between October 1st, 2005, and June 30, 2007, were included in this study. Clinical features including gestational age, body weight at hospitalization, rectal temperature, the day after birth, place of delivery were recorded at the time of hospitalization. Hypothermia was classified as per WHO classification.
Results
In 52 hypothermic neonates, 36 patients (69.3%) survived and 16 patients (30.7%) died. There was a significant statistical difference between survival group and no survival group regarding rectal temperature (31.1±2.7°Cvs. 28.7±2.3°C; mean±SD, p=0.003). All patients who died during hospitalization had below 33°C of rectal temperature at hospitalization. As for WHO classification, the severe hypothermic group had higher mortality rate than the moderate hypothermic group (45.2% vs. 9.5%, p=0.006). There was no significant statistical difference for body weight at hospitalization, the day after birth and gestational age in two groups. The severe hypothermic group was higher in the ratio of delivery at the domicile than those of moderate hypothermic group (22.6% vs. 0%, p=0.020). In multiple logistic regression analysis accounting for rectal temperature, the day after birth and body weight at hospitalization, only rectal temperature was significantly associated with survival rate (odds ratio 1.408, 95% confidence interval 1.088−1.821, p=0.009).
Conclusion
Between the moderate hypothermic neonates and the severe hypothermic neonates classified WHO classification, there was a significant difference between the mortality rate. It is important to keep the rectal temperature more than 32°C. The rectal temperature is an associated factor for hypothermic neonatal mortality which is easily measured at hospitalization in rural hospital in morocco.
2.Practice and Educational Effects of a Simulated Randomized Controlled Trial for Acupuncture School Teachers
Tomoyuki NABETA ; Rina KOBAYASHI ; Yoshihisa KOJIMA ; Hitoshi YAMASHITA
Journal of the Japan Society of Acupuncture and Moxibustion 2010;60(2):182-189
[Objective]To motivate acupuncture school teachers to introduce higher-quality methodology in clinical acupuncture research.
[Methods]Twenty-eight teachers from 18 acupuncture schools participated in the simulated randomized, subject and evaluator-blinded, and sham-controlled trial of acupuncture for low back pain. Twenty of them played a role as subjects, four of them were raters, and another four were therapists. Before and after conducting the trial, all the participants were asked several questions using the Visual Analogue Scale (VAS) regarding necessity of Evidence-Based Medicine (EBM) in acupuncture and their level of understanding of several terms related to a Randomized Controlled Trial (RCT),
[Results]After the simulated RCT, the understanding level of all terms related to RCT increased significantly ("RCT":from 58.0 ± 27.2 to 75.5 ± 25.7, "informed consent":from 88.1 ± 15.4 to 99.2 ± 10, "recruitment":from 43.0 ± 41.0 to 74.8 ± 31.3, "random allocation":from 55.5 ± 35.0 to 78.7 ± 25.8, "masking":from 54.7 ± 35.0 to 79.0 ± 26.0) (mean ±SD). Nineteen teachers answered that they would try to conduct RCT and introduce it to their education program.
[Conclusion]The results suggest that the practice of simulated RCT is effective in understanding RCT and motivating acupuncture teachers to introduce it to their education program.
4.A Case of Acute Arterial Occlusion of the Lower Extremity Caused by Huge Vegetation of Prosthetic Valve Endocarditis
Kizuku Yamashita ; Tomoyuki Fujita ; Hiroki Hata ; Yusuke Shimahara ; Shunsuke Sato ; Junjiro Kobayashi
Japanese Journal of Cardiovascular Surgery 2013;42(4):284-288
A 79-year-old woman with prosthetic valve endocarditis (PVE) on aortic position underwent re-aortic valve replacement. Although emergency operation was indicated due to huge vegetation over 20 mm in diameter attached to the prosthesis shown by preoperative transesophageal echocardiography, intraoperative transesophageal echocardiography showed disappearance of the vegetation. The prosthesis was carefully removed and replaced by a new bioprosthesis, though only small vegetation was observed on the removed prosthesis. Sudden blue toe 11 h after the operation and diminished pulse on right pedal artery suggested an acute arterial occlusion of a right lower extremity, requiring an emergency thrombectomy. Pathology diagnosed bacterial embolus with fresh thrombus that was considered apart from the prosthesis at the time of operation.
5.Computer-Assisted Rotational Acetabular Osteotomy for Patients with Acetabular Dysplasia.
Yutaka INABA ; Naomi KOBAYASHI ; Hiroyuki IKE ; So KUBOTA ; Tomoyuki SAITO
Clinics in Orthopedic Surgery 2016;8(1):99-105
Rotational acetabular osteotomy (RAO) is a well-established surgical procedure for patients with acetabular dysplasia, and excellent long-term results have been reported. However, RAO is technically demanding and precise execution of this procedure requires experience with this surgery. The usefulness of computer navigation in RAO includes its ability to perform three-dimensional (3D) preoperative planning, enable safe osteotomy even with a poor visual field, reduce exposure to radiation from intraoperative fluoroscopy, and display the tip position of the chisel in real time, which is educationally useful as it allows staff other than the operator to follow the progress of the surgery. In our results comparing 23 hips that underwent RAO with navigation and 23 hips operated on without navigation, no significant difference in radiological assessment was observed. However, no perioperative complications were observed in the navigation group whereas one case of transient femoral nerve palsy was observed in non-navigation group. A more accurate and safer RAO can be performed using 3D preoperative planning and intraoperative assistance with a computed tomography-based navigation system.
Acetabulum/diagnostic imaging/*surgery
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Adult
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Female
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Hip Dislocation/diagnostic imaging/*surgery
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Humans
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Imaging, Three-Dimensional
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Male
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Osteotomy/*methods
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Surgery, Computer-Assisted/*methods
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Tomography, X-Ray Computed
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Young Adult
6.Sublingual Immunotherapy for Japanese Cedar Pollinosis Attenuates Asthma Exacerbation
Sayaka KIKKAWA ; Kazuyuki NAKAGOME ; Takehito KOBAYASHI ; Tomoyuki SOMA ; Atsushi KAMIJO ; Makoto NAGATA
Allergy, Asthma & Immunology Research 2019;11(3):438-440
No abstract available.
Asian Continental Ancestry Group
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Asthma
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Cryptomeria
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Humans
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Rhinitis, Allergic, Seasonal
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Sublingual Immunotherapy
7.A Case of Immunoglobulin G4-Related Thoracic Aortic Aneurysm Initially Diagnosed as Aortic Intramural Hematoma
Minoru MATSUHAMA ; Takuma KOBAYASHI ; Takashi KUNIHARA ; Tomoyuki GOTO
Japanese Journal of Cardiovascular Surgery 2018;47(2):88-92
Immunoglobulin G4 (IgG4)-related disease is a chronic disease characterized by fibrotic mass and/or thickened lesions with elevated serum IgG4 concentrations, and infiltrations of IgG4 positive plasma cells. Since it has recently been reported to occur in the cardiovascular system, therapeutic strategy needs to be established. We report a case of IgG4-related thoracic aortic aneurysm (IgG4-R TAA) which was diagnosed postoperatively though suspected as aortic intramural hematoma preoperatively. A 70-year-old man who has medical histories of retroperitoneal fibrosis twice visited our hospital with chief complaints of cough and a CT scan was performed. Though there had been no episodes related to the onset of aortic dissection such as chest pain, an ascending aortic intramural hematoma of 52 mm in diameter was suspected and we planned to perform hemi-arch replacement. Intraoperative findings suggested that it was a true aneurysm and there was no sign of dissection. Histopathologically, the adventitia was obviously thickened with infiltrations of IgG4 positive plasma cells without infiltrations and dissection findings in the tunica media. In addition, serum IgG4 exceeded the normal value, thus it was diagnosed as IgG4-R TAA on the basis of the comprehensive diagnostic criteria. Great caution should be taken in IgG4-R TAA because it may show intramural hematoma on imaging and may develop aortic dissection and rupture as well.
8.Influence of Skeletal Muscle Mass and Spinal Alignment on Surgical Outcomes for Lumbar Spinal Stenosis
Yawara EGUCHI ; Munetaka SUZUKI ; Hajime YAMANAKA ; Hiroshi TAMAI ; Tatsuya KOBAYASHI ; Sumihisa ORITA ; Kazuyo YAMAUCHI ; Miyako SUZUKI ; Kazuhide INAGE ; Kazuki FUJIMOTO ; Hirohito KANAMOTO ; Koki ABE ; Masaki NORIMOTO ; Tomotaka UMIMURA ; Yasuchika AOKI ; Masao KODA ; Takeo FURUYA ; Tomoaki TOYONE ; Tomoyuki OZAWA ; Kazuhisa TAKAHASHI ; Seiji OHTORI
Asian Spine Journal 2018;12(3):556-562
STUDY DESIGN: Retrospective observational study. PURPOSE: We considered the relationship between spinal alignment and skeletal muscle mass on clinical outcomes following a surgery for lumbar spinal stenosis (LSS). OVERVIEW OF LITERATURE: There are no reports of preoperative factors predicting residual low back pain following surgery for LSS. METHODS: Our target population included 34 women (mean age, 74.4 years) who underwent surgery for LSS. Prior to and 6 months after the surgery, systemic bone mineral density and lean soft tissue mass were measured using dual-energy X-ray absorptiometry. Skeletal muscle mass index (SMI) was calculated as the sum of the arm and leg lean mass in kilograms divided by height in meters squared. The spinal alignment was also measured. Clinical outcomes were evaluated using the Japanese Orthopedic Association scoring system, leg and low back pain Visual Analog Scale, and Roland–Morris Disability Questionnaire (RDQ). Additionally, we examined the bone mineral density, skeletal muscle mass, and spinal alignment before and after the surgery. We used the Spearman correlation coefficient to examine the associations among clinical outcomes, preoperative muscle mass, and spinal alignment. RESULTS: Sarcopenia (SMI <5.46) was observed in nine subjects (26.5%). Compared with normal subjects (SMI >6.12), RDQ was significantly higher in subjects with sarcopenia (p=0.04). RDQ was significantly negatively correlated with SMI (r=−0.42, p<0.05). There was a significant positive correlation between postoperative RDQ and pelvic tilt (PT; r=0.41, p<0.05). SMI and PT were significantly negatively correlated (r=−0.39, r<0.05). CONCLUSIONS: Good postoperative outcomes were negatively correlated with low preoperative appendicular muscle mass, suggesting that postoperative outcomes were inferior in cases of decreased appendicular muscle mass (sarcopenia). Posterior PT due to decreased limb muscle mass may contribute to postoperative back pain, showing that preoperatively reduced limb muscle mass and posterior PT are predictive factors in the persistence of postoperative low back pain.
Absorptiometry, Photon
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Arm
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Asian Continental Ancestry Group
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Back Pain
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Bone Density
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Extremities
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Female
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Health Services Needs and Demand
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Humans
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Leg
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Low Back Pain
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Muscle, Skeletal
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Observational Study
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Orthopedics
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Retrospective Studies
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Sarcopenia
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Spinal Stenosis
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Visual Analog Scale
9.Predicting outcomes to optimize disease management in inflammatory bowel disease in Japan: their differences and similarities to Western countries.
Taku KOBAYASHI ; Tadakazu HISAMATSU ; Yasuo SUZUKI ; Haruhiko OGATA ; Akira ANDOH ; Toshimitsu ARAKI ; Ryota HOKARI ; Hideki IIJIMA ; Hiroki IKEUCHI ; Yoh ISHIGURO ; Shingo KATO ; Reiko KUNISAKI ; Takayuki MATSUMOTO ; Satoshi MOTOYA ; Masakazu NAGAHORI ; Shiro NAKAMURA ; Hiroshi NAKASE ; Tomoyuki TSUJIKAWA ; Makoto SASAKI ; Kaoru YOKOYAMA ; Naoki YOSHIMURA ; Kenji WATANABE ; Miiko KATAFUCHI ; Mamoru WATANABE ; Toshifumi HIBI
Intestinal Research 2018;16(2):168-177
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is a chronic inflammatory disease of the gastrointestinal tract, with increasing prevalence worldwide. IBD Ahead is an international educational program that aims to explore questions commonly raised by clinicians about various areas of IBD care and to consolidate available published evidence and expert opinion into a consensus for the optimization of IBD management. Given differences in the epidemiology, clinical and genetic characteristics, management, and prognosis of IBD between patients in Japan and the rest of the world, this statement was formulated as the result of literature reviews and discussions among Japanese experts as part of the IBD Ahead program to consolidate statements of factors for disease prognosis in IBD. Evidence levels were assigned to summary statements in the following categories: disease progression in CD and UC; surgery, hospitalization, intestinal failure, and permanent stoma in CD; acute severe UC; colectomy in UC; and colorectal carcinoma and dysplasia in IBD. The goal is that this statement can aid in the optimization of the treatment strategy for Japanese patients with IBD and help identify high-risk patients that require early intervention, to provide a better long-term prognosis in these patients.
Asian Continental Ancestry Group
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Colectomy
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Colitis, Ulcerative
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Colorectal Neoplasms
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Consensus
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Crohn Disease
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Disease Management*
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Disease Progression
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Early Intervention (Education)
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Epidemiology
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Expert Testimony
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Gastrointestinal Tract
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Hospitalization
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Humans
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Inflammatory Bowel Diseases*
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Japan*
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Prevalence
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Prognosis