1.Efficacy and Safety of Goreisan for Chronic Heart Failure Patients with Chronic Kidney Disease
Ryudo KAWAHARA ; Koki CHIBA ; Hiroko TAKAHASHI ; Kazuhiko NARA ; Koichiro TANAKA ; Tomoyuki ATA ; Hiroshi HASHIDOMI ; Hiroshi DOUMAE
Kampo Medicine 2019;70(1):57-64
Although evidence of Western therapy for heart failure has been established, evidence of treatment for heart failure with chronic kidney disease (CKD) has still not been established. The efficacy of additional Oriental medicine to standard therapy for heart failure with CKD is unclear. To address this issue, we retrospectively evaluated 20 consecutive heart failure patients with CKD (≧stage 3) who were orally administered goreisan (7.5 g/day) due to insufficient efficacy of standard therapy in our hospital from November 2015 to December 2017. We assessed symptoms, chest X-ray, BNP concentration, serum electrolytes, eGRF, plasma osmolality, and side effects. Goreisan improved heart failure in 11 of 20 patients, did not significantly deteriorate renal function, plasma osmolality, and did not clinically affect electrolytes. In conclusion, the present study suggested that additional use of goreisan to Western standard therapy is safe and useful for heart failure with CKD.
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