Chromatography, Gas ; methods ; Humans ; Toluidines ; blood

Demodex mites are considered part of the normal skin flora. Typically, Demodex is harmless and causes no clinical symptoms. We present a 43-year-old woman with pruritic erythematous plaque and papulopustular eruptions on the right cheek. The patient was treated seborrheic dermatitis in face from several years ago. However, the lesion was aggravated after continuous topical steroid usage for several months at a local clinic. Histological examinations revealed Demodex mites in the follicular ostia with perivascular and perifollicular lymphohistiocytic inflammation. Treatment was initiated with metronidazole at a dose of 250 mg three times per day and then crotamiton ointment once daily. The lesion showed marked improvement after six weeks of treatment with mild residual erythema. The findings presented here indicate that Demodex infestation should be considered in the differential diagnosis of unilateral follicular eruptions of the face.
Adult ; Cheek ; Dermatitis, Seborrheic ; Diagnosis, Differential ; Erythema ; Female ; Humans ; Inflammation ; Metronidazole ; Mites ; Skin ; Toluidines

Crusted (Norwegian) scabies is a clinical variant of human infestation with Sarcoptes scabiei, and is characterized by extensive, heavily crusted skin lesions. It usually affects immunocompromised patients. The diagnosis is commonly missed, and can lead to mismanagement. Here we report a case of crusted scabies misdiagnosed as a cutaneous side reaction due to allopurinol in a 48 year old male patient with acquired perforating dermatosis who had been treated with allopurinol for about 20 weeks. The lesion showed pruritic, excessive hyperkeratotic scaly crusts and fissures on the hands, and on pelvic, genital and inguinal areas. His skin lesions disappeared after treatment with 10% crotamiton cream for 2 weeks.
Allopurinol ; Hand ; Humans ; Immunocompromised Host ; Male ; Sarcoptes scabiei ; Scabies ; Skin ; Skin Diseases ; Toluidines

Acute Disease ; Chemical and Drug Induced Liver Injury ; etiology ; Humans ; Male ; Middle Aged ; Toluidines ; poisoning ; Young Adult

Objective: A method for the determination of acetochlor and its metabolites in urine by liquid chromatography-tandem mass spectrometry (LC-MS/MS) was established. Methods: After cleaned-up by a HLB extraction cartridges, the urine was eluted with 1% acetic acid acetonitrile solution. The target compounds were separated by ACQUITY UPLC®HSS T3 Column (2.1 mm×100 mm×1.8 μm) by using 1% formic acid solution and acetonitrile as mobile phase with gradient elution program, and analyzed in positive electrospray ionization mode by liquid chromatography tandem mass spectrometry. Results: All the target compounds showed good linear relationships in the range of 1-50 μg/L, and the correlation coefficients (r) were higher than 0.997. The recoveries rates at three different spiked levels for all target compounds in blank matrices were 107.6%-129.1%, and the relative standard deviations (RSD) were 1.5%-9.9% (n=6) . The limits of detection and quantitation of the method were 0.04-0.11 μg/L and 0.15-0.42 μg/L, respectively, and target substances were detected in all urine samples from occupational exposure workers to acetochlor. Conclusion: This method is suitable for rapid screening and analysis of acetochlor and metabolites in urine with the advantages of accuracy, rapidity, simplicity, high sensitivity and good specificity.
Acetonitriles ; Chromatography, High Pressure Liquid ; Chromatography, Liquid ; Humans ; Solid Phase Extraction ; Tandem Mass Spectrometry ; Toluidines

PURPOSE: To evaluate of the range and relationship between intraocular pressure (IOP), and central corneal thickness (CCT) in premature infants. METHODS: To investigate the correlation of IOP and CCT with gestational age and body weight, 58 premature infants 37 weeks-old or younger were examined. Under topical anesthesia, IOP was measured with Tono-Pen(R) XL (Medtronic Solan, Jacksonville, FL) and the CCT with pachymeter (SP-2000, TOMEY(R), Japan). The fundus was examined in infants with a risk of retinopathy of prematurity (ROP). RESULTS: Average gestational age of the subjects was 33 weeks and 6 days and body weight was 1506+/-520 grams (mean+/-standard deviation). Forty-five subjects had oxygen therapy, and 10 patients were found to have any one of the stages of ROP. Average IOP was 15.14+/-4.64 mmHg in the right eye and 15.29+/-3.70 mmHg in the left eye. CCT was 594.72+/-74.87 micrometer in the right eye and 599.78+/-74.17 micrometer in the left eye. No statistically significant correlation was found between IOP or CCT and gestational age or body weight. CONCLUSIONS: Gestational age and body weight did not appear to affect IOP or CCT in the gestational age between 26 and 37 weeks. The maturing eye in the neonate is known for fast development in the first year after birth. There are, however, few reports in the literature regarding the changes in dimensions of ocular structures in the premature neonate. These normative values may aid ophthalmologists in assessing IOP and CCT in premature infants.
Anesthesia ; Body Weight ; Diterpenes ; Eye ; Gestational Age ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Intraocular Pressure ; Oxygen ; Parturition ; Retinopathy of Prematurity ; Toluidines

PURPOSE: To evaluate of the range and relationship between intraocular pressure (IOP), and central corneal thickness (CCT) in premature infants. METHODS: To investigate the correlation of IOP and CCT with gestational age and body weight, 58 premature infants 37 weeks-old or younger were examined. Under topical anesthesia, IOP was measured with Tono-Pen(R) XL (Medtronic Solan, Jacksonville, FL) and the CCT with pachymeter (SP-2000, TOMEY(R), Japan). The fundus was examined in infants with a risk of retinopathy of prematurity (ROP). RESULTS: Average gestational age of the subjects was 33 weeks and 6 days and body weight was 1506+/-520 grams (mean+/-standard deviation). Forty-five subjects had oxygen therapy, and 10 patients were found to have any one of the stages of ROP. Average IOP was 15.14+/-4.64 mmHg in the right eye and 15.29+/-3.70 mmHg in the left eye. CCT was 594.72+/-74.87 micrometer in the right eye and 599.78+/-74.17 micrometer in the left eye. No statistically significant correlation was found between IOP or CCT and gestational age or body weight. CONCLUSIONS: Gestational age and body weight did not appear to affect IOP or CCT in the gestational age between 26 and 37 weeks. The maturing eye in the neonate is known for fast development in the first year after birth. There are, however, few reports in the literature regarding the changes in dimensions of ocular structures in the premature neonate. These normative values may aid ophthalmologists in assessing IOP and CCT in premature infants.
Anesthesia ; Body Weight ; Diterpenes ; Eye ; Gestational Age ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Intraocular Pressure ; Oxygen ; Parturition ; Retinopathy of Prematurity ; Toluidines

MOUTH DISEASES PROSPECTIVE STUDIES BIOPSY STAINS AND STAINING HISTOLOGICAL TECHNICS TOLUIDINES PHENOTHIAZINES SULFUR COMPOUNDS ORGANIC CHEMICALS EARLY DIAGNOSIS DIAGNOSIS TOLONIUM CHLORIDE

This article reviews newly available knowledge regarding occupational cancer based on an assessment of International Agency for Research on Cancer (IARC) Monograph program from 2006 to 2010. The IARC reviewed the agents to evaluate the carcinogenicity in humans according to their priority. During the last five years, the IARC has reviewed many kinds of agents, including all of the Group 1 carcinogenic agents. Agents belonging to groups other than Group 1 were also reviewed. A few agents, such as shiftwork and firefighting, were reviewed for the first time after introducing the IARC Monograph Program. Most of the reassessed Group 1 agents were reaffirmed, showing that there was sufficient evidence to prove their carcinogenicity to human beings. However, some carcinogens were correlated to the new cancer site, since it was deemed that sufficient evidence was present. For example, larynx and ovary cancer deemed to have sufficient evidence of carciongenicity relating to asbestos exposure, joining lung cancer and mesothelioma. Some agents, such as benzo(a)pyrene, ortho-toluidine, 1,3-butadiene, and others belonging to Group 2A were upgraded to Group 1 based on newly identified epidemiologic findings, along with sufficient animal and mechanistic evidence. Benzo(a)pyrene and benzidine-based dyes were classified as human carcinogens based on sufficient animal and pervasive mechanistic evidence. This new data shows that not only chemical agents but also working conditions, such as stress and shiftwork were found to apply to human carcinogenicity. The IARC listed these agents in order to prioritize their review regarding their carcinogenicity to humans. There is a great need to study these newly emerging agents suspected to relate human carcinogenicity, and deem they are worthy of notice.
Animals ; Asbestos ; Benzo(a)pyrene ; Butadienes ; Carcinogens ; Coloring Agents ; Firefighters ; Humans ; International Agencies ; Larynx ; Lung Neoplasms ; Mesothelioma ; Ovarian Neoplasms ; Polymethacrylic Acids ; Toluidines

Amitraz is acaricidal and insecticidal pesticide used worldwide to control ticks and mites in plants and animals. Amitraz poisoning is characterized by clinical toxidrome such as central nervous system, respiratory depression, bradycardia, hypotension, hypothermia, and hyperglycemia. Toxic mechanism of amitraz is mainly alpha2-agonistic function and poisonings may occur by any route. Such clinical symptoms and signs of acute amitraz poisoning were possible to be thought as a toxidrome of acute organophosphate poisoning. We reported a 68-year-old woman that initially was misdiagnosed as acute organophosphate poisoning on the ground of symptoms and signs of mental change, respiratory depression, bradycardia, and hypotension. However, the serum level of pseudocholinesterase level at emergency room admission was within normal level and a vacant bottle of amitraz pesticide was founded around the yard of the patient. The patient was totally recovered from acute amitraz poisoning 2 days later after mechanical ventilation and conservative cares including atropine injection.
Animals ; Atropine ; Bradycardia ; Central Nervous System ; Emergencies ; Female ; Humans ; Hyperglycemia ; Hypotension ; Hypothermia ; Mites ; Organophosphate Poisoning ; Organophosphates ; Pseudocholinesterase ; Respiration, Artificial ; Respiratory Insufficiency ; Ticks ; Toluidines