OBJECTIVETo observe the postburn changes in the plasma levels of ICAM-1, IL-10 and TNFalpha during early postburn stage.

METHODSNineteen burn patients were enrolled in the study. The plasma levels of the above 3 kinds of factors were determined with ELISA in the peripheral plasma of the patients, plasma samples from 11 healthy volunteers were taken as the control.

RESULTSThe plasma levels of ICAM-1, IL-10 and TNFalpha increased obviously postburn, especially in those patients who were complicated with hypovolumic shock, sepsis and MODS (P < 0.05 - 0.01).

CONCLUSIONThe monitoring of the postburn changes in plasma levels of ICAM-1, IL-10 and TNFalpha might be helpful in the forecast of postburn sepsis and the development of MODS.

Adult ; Burns ; immunology ; Female ; Humans ; Intercellular Adhesion Molecule-1 ; blood ; Interleukin-10 ; blood ; Male ; Middle Aged ; Multiple Organ Failure ; immunology ; Sepsis ; immunology ; Shock ; immunology ; Time Factors ; Tumor Necrosis Factor-alpha ; analysis