Research in the field of tissue regeneration is a new focus in life science and medicine in the 21st century, hereby I express my personal expectations of its research and translational application in the future.
Regenerative Medicine ; trends ; Tissue Engineering ; Wound Healing

Micro- and nano-structured surfaces of scaffold materials have important effects on cells' adhesion and proliferation. Nano-structured surfaces can improve cells' adhesion and biocompatibility of materials. The effects of nano-biomaterials on the development of tissue engineering and the methods of preparation of nano-biomaterials such as molecular self-assemble and template technology are discussed.
Biocompatible Materials ; Humans ; Nanotechnology ; trends ; Tissue Engineering

It is no doubt that the gene therapy using recombinant engineering cells provides a novel approach to many refractory diseases. However, the transplant rejection from the host's immune system against heterogeneous cells has been the main handicap of its clinical application. The modern cell micro-encapsulation technique with good immune isolation makes it possible to overcome this problem and has shown potential application foreground in clinical therapies for a lot of diseases such as Parkinson's disease and Hemophiliac disease. This article reviews mainly the relative materials and techniques in processing micro-encapsulation, the host cells used to construct the recombinant genetic engineering cells and application of cell micro-encapsulation technique in the field of gene therapy.
Biomedical Engineering ; methods ; trends ; Cell Transplantation ; methods ; trends ; Genetic Therapy ; trends ; Humans ; Miniaturization ; Tissue Engineering ; methods ; trends

In recent years, the applications of atomic force microscopy (AFM) have underpinned the fast progress in the area of tissue engineering. Besides the study of surface morphology in the dimension of micro- and nano-, AFM has played an important role in the fabrication of micro- and nano-structure as well as in the investigation of mechanical properties of material and cell. This overview is aimed to introduce the principle of AFM and to review its recent applications in tissue engineering.
Humans ; Microscopy, Atomic Force ; Nanotechnology ; Tissue Engineering ; trends ; Tissue Scaffolds

Tissue engineering has typically been such an approach that relies on isolation and culture of primary cells (seed cells), seeding these cells onto porous scaffolds, maintaining under static or flow condition (Bioreactor) for a period of time prior to implantation. However, experience of almost thirty years in this research field tells us that the typical tissue engineering approach relies on autologous cells, expensive and time consuming. Tissue engineering products do not function very well and are difficult to get FDA approval. In recent years biomaterial scientists created a new concept "Tissue Inducible Biomaterials". The concept is based on designing of microstructure of scaffolds, chemical modification and incorporation of bioactive molecule to scaffolds. Thus the scaffolds gain tissue induction activity, and will facilitate tissue regeneration and repair in vivo. The concepts of "In Vivo Tissue Engineering" and "Tissue Inducible Biomaterials" are been recognized by the Society, and are becoming the new approaches in tissue engineering: Based on the research of the related references within the past three years, the present paper summarized the strategy of tissue inducible biomaterials.
Animals ; Biocompatible Materials ; chemistry ; Guided Tissue Regeneration ; Humans ; Tissue Engineering ; trends ; Tissue Scaffolds ; trends

As one of the key factors for tissue engineering, scaffolds affect the spread and proliferation of seeded cells and the formation of new tissue. Although conventional methods can produce porous scaffolds with different porosities, they are lack controls the porous structures of the scaffolds. In recent years, rapid prototyping (RP) techniques have been developed and have successfully applied to fabricate TE scaffolds. RP techniques can provide accurate control over internal pore architectures and complex-shapes. As a result of these techniques, ideal tissue-engineered constructs could be prepared. This paper reviewed the advantages, potential and future directions of RP techniques in the design and fabrication of TE scaffolds.
Computer-Aided Design ; Porosity ; Tissue Engineering ; methods ; trends ; Tissue Scaffolds ; trends

Bladder has many important functions as a urine storage and voiding organ. Bladder injury caused by various pathological factors may need bladder reconstruction. Currently the standard procedure for bladder reconstruction is gastrointestinal replacement. However, due to the significant difference in their structure and function, intestinal segment replacement may lead to complications such as hematuria, dysuria, calculi and tumor. With the recent advance in tissue engineering and regenerative medicine, new techniques have emerged for the repair of bladder defects. This paper reviews the recent progress in three aspects of urinary bladder tissue engineering, i.e., seeding cells, scaffolds and growth factors.
Humans ; Intercellular Signaling Peptides and Proteins ; Regenerative Medicine ; trends ; Tissue Engineering ; trends ; Tissue Scaffolds ; Urinary Bladder

Tissue engineering technology and stem cell research based on tissue engineering have made great progresses in overcoming the problems of tissue and organ damage, functional loss and surgical complications. Traditional method is to use biological substitute materials to repair tissues, while tissue engineering technology focuses on combining seed cells with biological materials to form biological tissues with the same structure and function as its own to repair tissue defects. The advantage is that such tissue engineering organs and tissues can solve the problem that the donor material is limited, and effectively reduce complications. The purpose of tissue engineering is to find suitable seed cells and biomaterials which can replace the biological function of original tissue and build suitable microenvironment . This paper mainly describes current technologies of tissue engineering in various fields of urology, and discusses the future trend of tissue engineering technology in the treatment of complex urinary diseases. The results of this study show that although there are relatively few clinical trials, the good results of the existing studies on animal models reveal a bright future of tissue engineering technology for the treatment of various urinary diseases.
Animals ; Biocompatible Materials ; Humans ; Tissue Engineering ; trends ; Tissue Scaffolds ; Urology ; trends

Heart Failure ; therapy ; Humans ; Myocardium ; Tissue Engineering ; methods ; trends

Application research on human amniotic membrane has been carried out for nearly a hundred years and people found that there were more than dozens of kinds bioactive substances in the amniotic membrane. It has been proved that the amniotic membrane has a lot of functions, such as anti-inflammatory, anti-bacterial, anti-virus, anti-angiogenic and promoting cell apoptosis, and soon. As effective treatments, amniotic membrane has been used for adjunctive therapy of burns, trauma, ophthalmic damage, dermatopathya. Recent advances of amniotic membrane and amniotic membrane-derived cells research have led to enormous progress in skin tissue engineering, vascular tis- sue engineering, biological scaffold material, and biological sustained-release materials. Amniotic membrane and amniotic membrane derived cells have a significant advantage and unique charm in medical field. Therefore, they have higher research value and broad prospects in the applications.
Amnion ; Biomedical Research ; trends ; Humans ; Tissue Engineering ; Treatment Outcome