OBJECTIVE:To study the mechanisms of GJKL(Gujikang liniment) in treatment of soft tissue injury METHO_DS:The effects of intraperitoneal injection of acetic acid solution on capillary permeability were observed;An animal model of soft tissue injury was established by striking The effects of GJKL on hemorheological parameters were observed RESULTS:GJKL markedly inhibited capillary permeability and decreased hemorheological parameters CONCLUSION:GJKL takes therapeutic effects on soft tissue injury through inhibiting the increased capillary permeability and reducing the hemorheological parameters

Objective Cancer radio-therapy may induce bone damage of the patients.collagen type I gene expressions in osteoblast after radiation indicates the influence of radiation on the function of early and late osteoblast.Methods Bone marrow stromal cells were differentiated into osteoblasts in vitro.and the characteristics was indentified.The collagen type I expressions in early and late stage osteoblasts exposed to 1～4Gy radiation were examined by RT-PCR.Results Compared to control group,collagen type I gene expressions increased in early osteoblast after 1～3 Gy radiation (P＜0.05),while the gene expressions in late osteoblast that cultured 10 days decreased.Collagen type I gene expression in late stage ostoblast after 4 Gy irradiation was greatly higher than that in early stage osteoblast (P＜0.01).Conclusion After 1～3 Gy irradiation,the collagen type I expression in early osteoblast was enhanced,indicating the increased ability of bone formation.The exposure to 1～3 Gy decreased collagen type I expression in late osteoblast and weakened the ability of bone formation.The result of high expression of collagen type I in late osteoblast after 4 Gy irradiation may be the manifestation of compensatory function.