1.SIRT6 as a key event linking P53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation.
Yanying ZHOU ; Xiaomei FAN ; Tingying JIAO ; Wenzhou LI ; Panpan CHEN ; Yiming JIANG ; Jiahong SUN ; Yixin CHEN ; Pan CHEN ; Lihuan GUAN ; Yajie WEN ; Min HUANG ; Huichang BI
Acta Pharmaceutica Sinica B 2021;11(1):89-99
Acetaminophen (APAP) overdose is the leading cause of drug-induced liver injury, and its prognosis depends on the balance between hepatocyte death and regeneration. Sirtuin 6 (SIRT6) has been reported to protect against oxidative stress-associated DNA damage. But whether SIRT6 regulates APAP-induced hepatotoxicity remains unclear. In this study, the protein expression of nuclear and total SIRT6 was up-regulated in mice liver at 6 and 48 h following APAP treatment, respectively.
Result Analysis
Print
Save
E-mail