Objective:To evaluate the value of platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR) in predicting short-term prognosis of acute severe carbon monoxide poisoning.Methods:Clinical data of 180 patients with acute severe carbon monoxide poisoning admitted to Hanzhong Central Hospital from October 2021 to May 2023 were retrospectively analyzed. According to the prognosis of the patients within 6 months, they were divided into poor prognosis group ( n=37) and good prognosis group ( n=143). The baseline data and laboratory indicators of the two groups were compared, and the risk factors of short-term poor prognosis in acute severe carbon monoxide poisoning patients were analyzed by multivariate logistic regression. The value of neutrophils (NEU), platelets (PLT), lymphocytes (LYM), PLR and NLR in predicting short term poor prognosis in patients with acute severe carbon monoxide poisoning was analyzed by receiver operating characteristic (ROC) curve. Results:The proportion of ≥60 years old, stroke history, exposure time >8 h and the levels of NEU, PLR and NLR in the poor prognosis group were higher than those in the good prognosis group, while the PLT and LYM were lower than those in the good prognosis group (all P<0.05). Multivariate logistic regression analysis confirmed that ≥60 years old, stroke history, exposure time >8 h, PLT, LYM, NEU, PLR, NLR levels were the risk factors for short-term poor prognosis in acute severe carbon monoxide poisoning patients (all P<0.05). According to ROC curve analysis, the areas under ROC curve of PLT, LYM, NEU, PLR and NLR to predict the short-term prognosis of acute severe carbon monoxide poisoning patients were 0.684, 0.702, 0.720, 0.889 and 0.801, respectively. Conclusions:Age, stroke history, exposure time, PLT, LYM, NEU, PLR and NLR levels are all factors affecting the short-term poor prognosis of patients with acute severe carbon monoxide poisoning. Increasing PLR and NLR levels will increase the risk of short-term poor prognosis of patients with acute severe carbon monoxide poisoning.

The laboratory physicians are high-level laboratory medicine talents who are in short supply in China at present. They should possess solid clinical and laboratory knowledge, skilled clinical laboratory techniques, clinical and laboratory analyzing ability, and good communicating skills. In our country, the resident training system for laboratory physicians has been basically established, but there is still room for improvement in the implementation of the training. In order to adapt to the needs of the new situation, focusing on the purpose of training and guided by the rules of standardized residency training, the clinical laboratory training base has kept exploring and practicing integrated teaching based on organ system in standardized residency training of clinical laboratory. Through the exploring and practicing, the clinical laboratory training base has tried to fulfill the integration of clinical disease diagnosis and treatment and laboratory analysis, to gradually establish a distinctive training and teaching model for laboratory physicians, and to train laboratory physicians to get competent to the work with initial ability. Meanwhile, the clinical laboratory training base has explored characterized experience for the training of master′s degree of clinical laboratory diagnostics in"Laboratory physician training experimental class".