Small for gestational age (SGA) infants are defined as infant with a birth weight below the 10th percentile of the average weight for gestational age or below 2 standard deviations for gestational age.More evidences have suggested that compared with the appropriate for gestational age infants,besides the short stature,there are also higher risks of lower intelligence,poor academic performance,low social competence,behavioral problems in SGA infants.

Objective To investigate the clinical efficacy of laparoscopic myomectomy surgery and open myomectomy surgery for the patients with uterine fibroids.Methods 78 patients with uterine fibroids in our hospital were divided into observation group and control group by random serial number,and each group had 39 cases.The observation group was given laparoscopic myomectomy,while the control group was given open myomectomy surgery.The average time,average blood loss,postoperative exhaust time and average postoperative hospitalization days were compared between the two groups.Results The operative time,blood loss,postoperative exhaust time and hospital stay time of the observation group were (113.3 ± 15.1) min,(50.5 ± 27.5) ml,(19.5 ± 5.1) h and (4.6 ± 0.5) d,while those in the control group were (61.5 ± 12.7) min,(100.9 ± 35.7) ml,(37.6 ± 4.9) h and (7.7 ± 0.6) d,the differences were significant between the two groups (t =11.79,10.35,8.06,7.11,all P ＜ 0.05).Conclusion Compared with open myomectomy surgery,laparoscopic myomectomy can not only shorten the hospital stay,but also reduce the time of discharge,and it is worth to be further promoted in clinical.

Objective To explore the value of hepcidin measurement in differential diagnosis of iron deficiency anemia(IDA) and anemia of chronic diseases(ACD) .Methods Serum hepcidin was measured by using ELISA .Serum iron(SI) and total iron binding capacity(TIBC) were determined by using Ferro zine colorimetric method .Results Hepcidin expression increased in ACD group (P<0 .05) ,but decreased in IDA group(P<0 .05) .The area under the curve of ROC for hepcidin ,SI and TIBC were 0 .97 ,0 .66 and 0 .85 respectively .Conclusion Hepcidin is a simple and safe indicator in differential diagnosis of IDA and ACD ,and its diagnos-tic accuracy is better than SI and TIBC .

Objective To investigate the clinical efficacy and safety on treatment of unstable angina pectoris (UAP) with low-molecular-weight heparins calcium .Methods 64 cases in our hospital from February 2012 to January 2013 with UAP were random-ly divided into treatment group and control group ,and 32 cases in each group .The control group was treated with routine drugs such as aspirin ,and the treatment group was treated with low-molecular-weight heparins calcium on the basis of routine therapy . The clinical efficacy and safety were evaluated by the frequency and duration of angina attacks ,the improvement of electrocardio-gram(ECG) and adverse reactions .Results The frequency and duration of angina attacks of the two groups were significantly re-duced and the performances of ECG were improved .The clinical improvement and performance of ECG were better in treatment group than those in the control group(P<0 .05) .And the total efficiency of the treatment group and control group were 93 .8%(30/32) and 84 .4% (27/32) ,respectively ,the difference had statistically significant (P<0 .05) .There was no serious adverse reac-tion in the two groups .Conclusion Low-molecular-weight heparins calcium can effectively control the frequency and duration of UAP and has less adverse reaction in treatment of UAP .It is worthy to be recommended in clinical .

OBJECTIVE:To construct a fuzzy optimized model based on entropy weight and to discuss the application of the model on the risk management of new drug research&development project.METHODS:Risk management model of new drug research&development projects was established by combining fuzzy mathematics and entropy weight theory.RESULTS:The new drug research&development projects can be optimized and ranked based on the evaluation results on the model.CONCLUSION:The fuzzy optimized entropy weight model can be applied for the evaluation in the risk management of new drug research&development projects,which serves as scientific base for the administrative decision.

Pseudoexfoliation syndrome (PEX) is an age-related systemic disease,with the features of fibrous stripped content widely deposit on the eye and other systemic organizations,which is associated with a rapid progress of cataract and secondary glaucoma in partial patients.The present study showed that the basement membrane injury,autoimmune disorders,and genetic factors were related to PEX,but the exact pathogenesis of PEX is still unclear.The purpose of this review was to discuss the recent progress in the pathogenesis and histopathology,expecting to contribute to the prevention and treatment of PEX.

Objective To study the changes of Vasodilator-stimulated Phosphoprotein phosphorylation which was dynamically regulated by cell adhesion to extracellular matrix,and to investigate the roles of VASP in the process of tumor cell adhesion and de-adhesion.Methods HeLa cells were divided into four groups: stably adherent cells,cells held in suspension,cells replated onto dishes coated with collagen I and positive control(cells treated with Forskolin).Changes in cell morphology were observed in inverted phase contrast microscope.Phosphorylation of VASP was detected by Western blot,and PKA activity was measured by PKA assay kit.(Results In) untreated,stably adherent cells,VASP was predominantly in the unphosphorylated form; Detachment of cells stimulated PKA activity and induced PKA-dependent phosphorylation of VASP;VASP was phosphorylated gradually following reattachment but returned to base level of phosphorylation during active cell spreading.Conclusion During the process of HeLa cell adhesion and de-adhesion,dynamical changes of VASP from the form of phosphorylation to dephosphorylation via PKA have been observed.

Objective:To investigate the effect of curcumin on the proliferation and the protein expression of Pleiotrophin(PTN) in cervical cancer Caski cells. Methods:MTT was used to assay the proliferation of Caski cells which were treated with different concentrations of curcumin. The immunocytochemistry was used to assay the distinctive expression of PTN in Caski cells which were treated by curcumin or not. The effects of curcumin with different concentrations on the protein levels of PTN were tested by Western blotting. Results:The proliferation of Caski cells were inhibited by curcumin in a does-dependent manner.Immunocytochemistry assessment showed the expression of PTN was significant down-regulated after treated with curcumin. Western blotting showed the curcumin could down-regulate the expression of PTN,and this was a does-dependent action. Conclusion:Curcumin could inhibit the proliferation and the PTN expression of Caski cells significantly,which may be one of the molecular mechanisms anticancer of curcumin.

Objective To investigate the value of serum apolipoprotein M (APOM)concentration in the diagnosis of bacterial pneumonia and its disease severity evaluation.Methods The serum APOM concentration was examined in 250 cases of pneumonia and 50 healthy controls by using the double antibody sandwich ELISA.The ROC curve was used to evaluate the diagnostic value of APOM on bacterial pneumonia and the Bayes discriminant analysis was adopted to construct the discriminant equation based on APOM concentration for evaluating its discriminant significance to the disease severity.Results The serum APOM concentration in the bacterial pneumonia group was (28.9±10.5)μg/mL,which was significantly higher than (19.4±8.93)μg/mL in viral pneu-monia group,(16.4±5.62)μg/mL in the other pneumonia group and(18.1 ±6.15)μg/mL in the healthy controls,the differences had statistical significance(P <0.01).The area under ROC curve for APOM in diagnosing bacterial pneumonia could reach 0.843, showing the good sensitivity and specificity.Moreover,the serum APOM concentration was positively correlated with the disease severity of bacterial pneumonia.The discriminant equation based on APOM concentration as well as sex,age,systolic pressure,body temperature and heart rate could better conduct the classification on the disease severity of bacterial pneumonia and its accuracy could reach to 86.7%.Conclusion The serum APOM concentration has an important clinical value for the diagnosis of bacterial pneumonia and its disease severity evaluation.

Obesity is mostly recognized as a chronic inflammatory condition in which the balance of normal state is destroyed and it is a risk of cardiovascular disease and many other chronic metabolic disease.Heme oxygenase-1 (HO-1),a major cytoprotective enzyme,exerts significant antioxidant and anti-inflammatory effects.It also can improve the function of fat cells and enhanced insulin sensitivity in obese individuals.The researches of HO-1 for the anti-inflammatory effects and its intervention have great significance in improving the inflammatory state and its related diseases in obesity.This paper elaborates the change of HO-1 and its effect for macrophage infiltration in obesity.