This paper reviews the clinical research on the treatment of chronic prostatitis with traditional Chinese medicine in recent years. It is believed that the core of the etiology and pathogenesis of this disease lies in the deficiency of spleen and kidney, dampness heat, phlegm turbid and blood stasis toxin. If the disease lasts for a long time, the spleen and kidney become to the deficiency from excess. The internal treatment of traditional Chinese medicine includes syndrome differentiation, disease differentiation or single prescription, while the external treatment mainly includes herbal bathing, enema, anal administration and acupuncture. Traditional Chinese medicine has advantages in the treatment of this disease. We should continue to study the the mechanism of traditional Chinese medicine for this disease, standardize the syndrome differentiation and treatment and outocmes evaluation, and carry out research on famous prescriptions on prostatitis.

The “eighteen antagonisms” of Chinese medicinals have been regarded as taboos in the field of traditional Chinese medicine （TCM）， and the connotations have gradually been narrowed down in the development of TCM. From the historical perspective， “eighteen antagonisms” are not an absolute taboo in terms of the combination of medicinals， and the existing types of antagonism medicinals are also worth further discussion. From the perspective of toxicological effects， the toxicology of the “eighteen antagonisms” mainly comes from the enhancement of the toxic and side effects of a certain herb， rather than the combination of two herbs. From the perspective of pharmacodynamic actions， the combination of some antagonism medicinals can achieve therapeutic effects that cannot obtained by conventional medicinals， which is feasible and reasonable in clinical practice. Therefore， it is believed that the application of combining some antagonism medicinals based on “eighteen antagonisms” is of positive significance. Moreover， strict combination， processing and decoction methods should be noted in the use of antagonism medicinals. All mentioned above will provide reference for the correct recognition and use of the combination of “eighteen antagonisms”， and broaden the combination thinking for the treatment of clinical diseases with TCM.

The “eighteen antagonisms” of Chinese medicinals have been regarded as taboos in the field of traditional Chinese medicine （TCM）， and the connotations have gradually been narrowed down in the development of TCM. From the historical perspective， “eighteen antagonisms” are not an absolute taboo in terms of the combination of medicinals， and the existing types of antagonism medicinals are also worth further discussion. From the perspective of toxicological effects， the toxicology of the “eighteen antagonisms” mainly comes from the enhancement of the toxic and side effects of a certain herb， rather than the combination of two herbs. From the perspective of pharmacodynamic actions， the combination of some antagonism medicinals can achieve therapeutic effects that cannot obtained by conventional medicinals， which is feasible and reasonable in clinical practice. Therefore， it is believed that the application of combining some antagonism medicinals based on “eighteen antagonisms” is of positive significance. Moreover， strict combination， processing and decoction methods should be noted in the use of antagonism medicinals. All mentioned above will provide reference for the correct recognition and use of the combination of “eighteen antagonisms”， and broaden the combination thinking for the treatment of clinical diseases with TCM.