Objective To evaluate the effects of renin-angiotensin system (RAS) blockades [angiotensin-converting enzyme inhibitors (ACEI) and angiotensin Ⅱ type 1 receptor blockers (ARB)]on contrast-induced nephropathy (CIN) in patients undergoing angiography.Methods Pubmed,Embase,Cochrane library,Wanfang database and CNKI were searched.The literature limited range was from their start year to July 2015.Randomized controlled trials (RCTs) and non-randomized controlled trials of renin-angiotensin system blockades in influencing CIN were assessed.Two investigators extracted data and performed quality analysis independently from all trims included.Rev man 5.3 software was used.Results 16 trials with a total of 15 897 patients were identified.There were 7490 patients who received renin-angiotensin system blockades and 8407 patients in control group.The meta analysis revealed a higher CIN incidence in ACEI/ARB group than that in control group (14.35％ vs 12.13％,P=0.04,OR=1.44,95％CI 1.01-2.04).For patients with renal insufficiency,ACEI/ARB group had a higher CIN incidence than control group (12.23％ vs 7.32％,P=0.02,OR=1.80,95％CI 1.10-2.94),and the serum creatinine changes in ACEI/ARB group were higher than those in control group.There was statistical difference in serum creatinine changes between groups (P=0.02,MD=0.08,95％CI 0.02-0.15).Conclusions Renin-angiotensin system blockades can increase theincidence of CIN in patients undergoing angiography.Renin-angiotensin system blockades can contribute to CIN for patients with renal insufficiency.

Objective To verify the feasibility and application value of arsenic-cerium catalytic spectrophotometry for determination of iodine in serum.Methods The blood samples of adults were collected and the iodine standard curve of 0-300 μg/L was prepared.Referring to "The Method for Determination of Chemical Substances in Biomaterials",the present method was tested in terms of linear relationship,minimum detection limit,precision and accuracy.Results The correlation coefficient of the method was-0.999 7--0.999 4 (n =6) and the minimum detection limit was 5.13 μg/L in the range of 0-300 μg/L standard curve.Precision verification displayed that the variable coefficient of three different iodine concentration serum samples were 0.89％,1.88％,0.67％.And the accuracy verification displayed that the recovery of iodine standard was 93.90％-107.04％,and the total average recovery was 99.48％.Conclusion The method has been proved to be of good linearity,high precision and high accuracy in the determination of serum iodine,which meets the requirements of biological sample analysis.