Prepulse inhibition(PPI)of the startle response is a complex auditory-behavioral re-sponse that provides a valuable method for assessing the auditory-sensory gating system in humans and experimental animals.Its neural pathway involves the central auditory cortex and is therefore important for exploring developmental changes in the auditory cortex of animals and humans,especially in infants and children.In this paper,we will summarize the research of PPI in the field of auditory science in re-cent years and discuss the future development trend.