Objective: To assess the efficacy and safety of thiazolidinediones combined with metformin in treatment of polycystic ovary syndrome. Methods: Electronic database searching was performed on Medline, Cochrane Library, EMbase, EBSCO, ScienceDirect, OVID, Springer LINK, Wiley, Chinese biology and medicine (CBM), China National Knowledge Infrastructure (CNKI), and Chongqing VIP Database; meanwhile, unpubished literature, conference papers and dissertations were also searched manually. The data included those from the establishment to November 2009. Randomized or clinical controlled trials concerning the thiazolidinediones and metformin combination therapy for PCOS were selected and assessed for the methodological quality, and Meta-analysis was performed using statistical software Revman 5. 0. Results: Five randomized controlled trials met the inclusion criteria and were included. Compared to metformin group, thiazolidinediones combined with metformin significantly improved insulin resistance(P<0.000 01, WMD=-0.21, 95%CI[-0.27, -0.15]) and ovulation rates (P=0.003, OR=2.76, 95%CI[1.14, 5.42]). There was no difference in WHR(P=0.51, WMD=0.02, 95%CI[-0.04, 0.08]) and serum testosterone(P=0.20, WMD=-31.14, 95%CI[-79.21, 16.92]) between the combination and metformin groups. However, single metformin therapy was shown to have more benefit in ameliorating BMI(P=0. 02, WMD=0.54, 95% CI[0.08, 1.00]) than the combination group. There were no serious adverse events during the treatment. Conclusion: Thiazolidinediones combined with metformin can greatly improve of insulin resistance and ovulation rates in PCOS women; besides, it is comparatively safe.

Objective: To conduct a numerical taxonomy research on the origin plants of Fructus Xanthii and to identify this crude drug, so as to provide evidence for the classification, identification and germplasm optimization of Xanthium genus. Methods: Fruits of Xanthium plants from 25 populations in China were collected and cultivated in the same location. Their growing conditions and morphological characteristics were observed after seedling emergence. And 20 taxonomic characters of the plants such as growth cycle, height of the whole plant, length of leafstalk, length and density of involucre, thorn, length of beak and color of ripe fruits, etc. were selected for detailed observation, recording and analysis. Original data matrix X= {Xii} 25×20 was established by means of 25 operational taxonomic units(OTU) and related 20 groups of characteristic data. The established matrix was analyzed using hierarchical cluster analysis on SPSS 13.0 software. Results and Conclusion: The origin plants of Fructus Xanthii from 25 populations of China fell into four groups, largely consistent with the morphological identification results of this study. The first group was identified as Xanthium sibiricum, the second as X. mongolicum, the: third as X. sibiricum var. subinerme, and the fourth was temporarily named as Shenzhen-type cocklebur Xanthium sp.. The Shenzhen-type cocklebur was special in some taxonomic characters and was possibly a cultivated variety of Xanthium genus. The origin plants of Fructus Xanthii in China can be systematized into 3 species and 1 type, which has been added to the existing taxonomic criteria. The cluster analysis method in this study can be applied for discrimination of Xanthium plants and crude drugs.

Whey protein has high biologic value and absorption rate.In its purest form, whey protein contains little fat,lactose or cholesterol and is a rich source of branched chain amino acid and bioactive peptides.The broad application prospect of whey protein on nutrition,medical care and food making are stressfully discussed.It provides a number of benefits in areas including cardiovascular, diabetes,immune support,infant nutrition,aging postpone,and general wellness etc.

Blindness ; etiology ; Embolism ; Endoscopy ; adverse effects ; Humans ; Male ; Middle Aged ; Paranasal Sinuses ; surgery ; Postoperative Complications ; Retinal Artery ; physiopathology ; Retinal Artery Occlusion ; complications ; etiology

Objective Severe preeclampsia (sPE), which is usually complicated by small-for-gestational-age (SGA) and immature labor , remains a leading cause of maternal and neonatal mortality and morbidity. This study was to investigate the risk factors of SGA in sPE. Methods We retrospectively analyzed 100 cases of sPE, 35 with SGA (the case group) and the other 65 without it ( the control group ) .We conducted single-factor analysis on the general characteristics and potential impact factors of the patients , i-dentified the independent risk factors of SGA using the un-conditional stepwise logistic model , and assessed the value of umbilical arter-y S/D ratio and proteinuria ration in the diagnosis of sPE with SGA with the ROC curve . Results Compared with the control group , the case group had more cases of early-onset sPE ( P =0.010 ), earlier gestational and delivery weeks (P<0.001), lower neonatal weight at birth ( P<0 .001 ) , higher rate of admission to and longer stay in the neonatal ICU (P<0.001), and higher incidence of neo-natal complications (P<0.05).The case group also showed signifi-cant increases in comparison with the control in the umbilical artery S/D ratio (2.95 ±0.75 vs 2.31 ±0.47, P<0.05), frequency of S/D ratio ≥95th percentile (22.86% vs 6.15%, P<0.01), and rate of proteinuria ≥5 g/24 h (42.86% vs 20.00%, P<0.05).The S/D ratio ≥95th percentile (OR=6.02, 95%CI:2.32-16.78) and proteinuria≥5 g/24 h (OR=1.65, 95%CI:1.56-3.01) were found to be the risk factors of sPE with SGA.The area under the curve was 0.852 for the combination of S/D ra-tio and proteinuria ration in the diagnosis of sPE with SGA (P<0.05). Conclusion Umbilical artery S/D ratio≥95th percentile and proteinuria ≥5 g/24 h contribute to the early prediction, prevention, and prognosis of sPE, and is valuable for the diagnosis of sPE with SGA.

Objective Toinvestigatetheclinicalfeaturesandsurgicalprognosisofmoyamoya syndromeinchildren.Methods Theclinicaldataof12childrenwithmoyamoyasyndromeadmittedto the 307th Hospital of People′s Liberation Army from December 2002 to October 2013 were analyzed retrospectively. Eleven of them underwent encephalo-duro-arterio-synangiosis (EDAS). A total of 550 children with moyamoya disease in the same period were used as a control group. The clinical characteristics and surgical efficacy of the children with moyamoya syndrome were summarized and concluded by comparing the clinical data of the two groups,including sex,age of onset,initial symptom,progress symptoms, Suzukiinstallments,imagingfeatures,andsurgicalefficacy.Results Themaleandfemaleratioof the children with moyamoya syndrome was 1∶2. Their mean age of onset was 12 ± 5 years old. There were significant differences in the initial symptom (cerebral infarction and cerebral hemorrhage )and disease progress between the children with moyamoya syndrome group and the control group (5/12 vs. 14. 5%[80/550], 3/12 vs. 61. 8%[340/550],and 5/12 vs. 8.7%[48/550],respectively;all P<0. 05). Within the follow-up period,of the 11 children underwent EDAS,7 cases had no further attack,and 4 cases were improved significantly. There was significant difference in the modified Rankin scale (mRS)between the beforeandaftersurgery(0[0,1]vs.2[1,2];P<0.05).Conclusions Theclinicalfeaturesofthe children with moyamoya syndrome have some differences with those with moyamoya disease. Timely and effective EDAS treatment may effectively prevent disease progression and improve the prognosis of patients.

Objective To investigate the proliferation effects induced by triiodothyronine (T3) in thyroid cancer cell lines,including follicular thyroid carcinoma cells (WRO),interstitial thyroid cancer cells (ARO) and papillary thyroid cancer cells (FB-2) and relationship with the thyroid receptor.Methods Different concentrations of thyroid hormone T3 inter acted on the three thyroid cancer cell lines,detected by MTT assay,achieved effective biological dose.To detect proliferation rates in all the cell lines using MTT assay,under the effective biological dose.RT-PCR and Western blot were used to detect the mRNA and protein expression of thyroid receptor.Results Cell proliferation induced depend on different concentrations (10 nmol/L,100 nmol/L and 1 μmol/L) thyroid hormone T3 in thyroid cancer cells FB-2,the proliferation rates were (128.78±0.31) ％,(171.94±0.40) ％,(178.04±0.14) ％,had dose-dependent relationship,which was the most effective physiological dose of 100 nmol/L,cell proliferation was significantly in WRO and ARO under 100 nmol/L[(149.06±0.06) ％,(158.87±0.03) ％],obviously in FB-2 [(167.92±0.08) ％].The expression in mRNA levels of thyroid receptor subtype TRα1 in WRO cells was more,low and no expression in the FB-2 and ARO,did not protein expression,mRNA and protein of subtype TRβ1 expressed in FB-2 and WRO cells,while expressed very little in ARO cells.Conclusion Thyroid hormone T3 can induce thyroid cell proliferation and expression of TRβ1 is relatively important.

Objective To study the expression of lectin-like oxidized LDL receptor-1 (LOX-1) protein in acute lung injury (ALI) and the effect of captopril on this expression in order to investigate its role in the process and preliminary intervention.Methods Sprague-Dawley rats were randomly divided into 3 groups,normal control group,lipopolysaccharide (LPS) groups,and a LPS+captopril group,each group 10 rats.ALI model was induced by intratracheal injection of LPS (5 mg/kg),then those of LPS+captopril group were give an intraperitoneal injection of captopril (1.25 mg/kg).The animals of normal control group received an intratracheal injection of normal saline.In 6 h after LPS injection,the level of p(O2),wet/dry ratio (W/D),concentration of total protein in bronchoalveolar lavage fluid (BALF) and lung tissue histopathological changes were examined.The expression of LOX-1 protein in the lung tissue was measured by Western blot analysis.HE staining was used to examine the pathological changes of the lung.Results Histological examination showed that extensive lung inflammation were seen in the LPS group,which manifested by accumulation of significant numbers of neutrophils.The level of p(O2) in LPS group [(6.86?0.75) kPa] was decreased compared with that in sham group [(12.14?0.60) kPa,P

Objective To investigate pathogenesis of liprd metabolism disorder in children with nephrotic syndrome. Methods Serum lipid and plasma llpoprotein lipase and hepatic lipase were detected in 62 nephrotic syndrome children and 30 normal children, respectively. Results The activity of lipoprotein lipase and hepatic lipase was lower than that in normal control group, while serum cholesterol, triglycerides and low -density lipoprotein in nephrotic group were higher than those in control group. Lipoprotein lipase and hepatic lipase were negative correlation with triglycerides and low - density lipoprotein, respectively. Conclusions Reduced activity of lipoprotein lipase and hepatic lipase is one of causes leading to hypertriglyceridemia in nephrotic syndrome.

Objective To explore the related factors on sore throat and pharyngeal xeransis during thyroid surgery.Methods Twenty-nine female patients, aged 24-67 years, BMI 18-30 kg/m2, falling into ASA physical status Ⅰ or Ⅱ, were scheduled for thyroid surgery.After anesthesia induction and tracheal intubation, the endotracheal intracuff was inflated to 20 mm Hg.Intracuff pressure was monitored every 5 minutes by a pressure transducer.At the time of 24 hours after tracheal intubation, the patients were asked about their throat complaints such as sore throat and pharyngeal xeransis.Results Endotracheal intracuff pressure during thyroid surgery was in a discrete distribution.Multiple linear regression model analysis found that age, BMI, anesthesia time and intracuff pressure had no obvious effects on sore throat.Decision tree model analysis found that patients undergoing thyroid surgery had higher probability of pharyngeal xeransis grade Ⅳ, when the average intracuff pressure was higher than 29 mm Hg.Conclusion Excessive endotracheal intracuff pressure during thyroid surgery due to operation causes pharyngeal xeransis.