Objective To explore the application effect of epidural labor analgesia for primipara.Methods 176 labor primipara were divided into observation group and control group by digital table.The control group was given non-drug labor analgesia,the observation group was given epidural labor analgesia.The analgesic effects of the two groups of childbirth way were recorded.Results After the intervention,in the observation group,the anxiety self-assessment rating scale,depression self rating scale score were (42.65 ±1.87)points,(45.76 ±3.05)points, which in the control group were (46.34 ±3.88)points,(51.93 ±4.95)points,there were statistically significant differences between the two groups(t=8.036,9.954,all P<0.05).In the observation group,the activematernal plasma cortisol,the first stages of VAS score,the second labor VAS score,the third labor VAS score were (31.06 ± 3.67)nmol/L,(1.88 ±0.45)points,(3.54 ±1.32)points,(2.43 ±1.19)points,which in the control group were (38.76 ±5.22)nmol/L,(2.78 ±0.96)points,(4.86 ±3.15)points,(3.85 ±2.21)points,there were statistically significant differences between the two groups(t=11.319,7.963,3.625,7.963,all P<0.05).In the observation group,the maternal postpartum haemorrhage amount,episiotomy rate,neonatal asphyxia rate were (186.71 ± 32.18)mL,14.78%,1.14%,which in the control group were (254.82 ±45.96)mL,35.23%,7.95%,there were statistically significant differences between the two groups(t=11.387,χ2 =9.818,4.714,all P<0.05).Conclusion Epidural labor analgesia application in primipara can reduce maternal negative psychological stress,relieve labor pain degree,reduce episiotomy rate and postpartum hemorrhage occurs,improve and outcomes and improve maternal and child safety,it is worth popularization and application in clinic.

Objective To investigate the influence of different excipients on the stability of baicalin solution.Methods The thermostatic accelerated test was used to observe the effect of solubilizing agent (Meglumine and Glucose), solubilizer (Pluronic F- 68) and stabilizer (HP- ? - CD) on baicalin stability and the concentration of baicalin was determined by HPLC. Results The valid period of baicalin solution with solubilizing agent added was shortened, and that with solubilizer and stabilizer added prolonged. Conclusion It is feasible to increase the stability of baicalin solution with Pluronic F- 68 or HP- ? - CD added. 

Adult ; Electrolysis ; Humans ; Lipid Peroxidation ; drug effects ; Male ; Middle Aged ; Nickel ; adverse effects ; blood ; pharmacokinetics ; Occupational Exposure ; adverse effects

Animals ; Cricetinae ; DNA Damage ; physiology ; Genes, p53 ; physiology ; Humans ; Mice ; Signal Transduction ; physiology

Background The pathogenesis of pterygium has been in the study.Relative molecular biology study showed that pterygium is a tumor-like lesion,and based on overseas literatures,human papillomavirus (HPV) is positively expressed in 100％ patients with pterygium in some region.However,if this result is suitable for Chinese patients is unclear.Objective This study was to identify the role of human HPV in the pathogenesis of pterygia in Wuxi area.Methods Forty-eight pterygium specimens including 7 recurrent pterygia and 41 primary pterygia were collected during the operation,and these patients were from Wuxi area.Two cervical carcinoma specimens and 2 conjunctiva specimens from normal donors were obtained as positive control and negative control respectively.The fluorescent quantitative polymerase chain reaction (FQ-PCR) was used to detect HPV DNA of specimens.Results The amplified curves of HPV 6,11 of pterygium specimens,cervical carcinoma specimens and normal specimens were all below the positive quality control curve,but the amplified curves of HPV16,18 were above the quality control curve in cervical carcinoma specimens; while those of pterygium specimens and normal conjunctival specimens were all below the quality control curve.HPV16/18 was identified in 2 cervical carcinoma specimens,but no HPV6/11 was detected in 2 cervical carcinoma specimens.However,HPV DNA expression in primary and recurrent pterygias were absent.Conclusions According to these results,HPV is not the primary cause for the pathogenesis of pterygium in Wuxi region.

AlM:To compare the functional and cosmetic effects of two different surgical techniques for congenital ptosis.
METHODS: The patients were divided into four groups according to the operation method: Patients undertook bilateral fascial suspension surgery as Group A ( 42 eyes of 21 cases ); Patients undertook bilateral levator muscle shortening surgery as Group B ( 38 eyes of 19 cases );Patients undertook unilateral fascial suspension surgery as Group C ( 24 eyes of 24 cases ); Patients undertook unilateral levator muscle shortening surgery as Group D (29 eyes of 29 cases). Each group patients were followed for postoperative function and appearance effect.
RESULTS: 1 ) Early postoperative of two operation function success rate was up to 100%, the function of levator muscle shortening surgery was 97. 01% in the late postoperative, was higher than bilateral fascial suspension surgery (87. 88%), with statistical difference in both surgerys (P<0. 05). 2) Appearance effect of two kinds of operation method in early postoperative had no statistical difference (P >0. 05); ln the late postoperative, the mean grades for “Lid Contour” and “Lid Crease” of Group B were better than that of Group A (P<0. 01). While the mean grades for “Lid Contour”, “Symmetry of Lid Height” and “Lid Crease” of Group D were similarly better than that of Group C (P<0. 01).
CONCLUSlON: Two kinds of operation method have good effects on the treatment of congenital ptosis. ln terms of cosmetic effect, levator muscle shortening surgery is better.

Objective To investigate the potential role of FoxP3-expressing CD4+CD25+ regulatory T cells in children with asthma.Met-hods Intracellular 3-colour flow cytometry and real time PCR were used to assess the expression of FoxP3 in peripheral blood mononuclear cell(PBMC)of asthma,repectively.Results There were similar frequencies of CD4+ CD25+ T cells in peripheral blood of asthma patients and healthy subjects.However,the percentage of CD4+CD25high and CD4+CD25+FoxP3+ in asthma group were lower than those in healthy subjects(Pa

Objective To explore the effect of early screening and psychotherapy on post stroke depression. Methods 80 patients with stroke at first onset were assessed with Hamilton Rating Scale for Depression (HAMD-17). Patients with depression were divided into control group (n=21) and intervention group (n=21). Both groups received rehabilitation therapy and the intervention group received psychotherapy in addition. They were assessed with HAMD again 2 months after treatment. All of them were evaluated with modified Barthel index (MBI). Results 52.5% patients had post stroke depression. The score of HAMD-17 was lower in the intervention group than in the control group (P<0.01). There was no significant difference in MBI between 2 groups after treatment (P>0.05). Conclusion Early screening and psychotherapy can facilitate the recovery of patients with depression after stroke.

OBJECTIVE: To study the potential targets and action mechanism of apatinib-treated breast cancer. METHODS: Combination with bioinformatic analysis, PharmMapper reverse docking technology was used to predict potential targets of apatinib and docking was performed using Autodock 4. 0 to examine the interaction of aptinib wih predicted protein targets. RESULTS: Cell division protein kinase 2,GTPase HRas, NONE and cytochrome P450 2C9 were found to be the potential targets of apatinib-treated breast cancer. Stable hydrogen bonds were formed between apatinib and the four predicted targets, and the binding free energy was low. CONCLUSION: Apatinib maybe participate the functional regulation or biological action of cell division protein kinase 2, GTPase HRas, NONE and Cytochrome P4502C9 to treat breast cancer, which provides a theoretical basis and a clue for further exploration of the mechanism research of apatinib-treated breast cancer.