Acute Disease ; Adult ; Female ; Humans ; Male ; Organometallic Compounds ; poisoning ; Poisoning ; therapy

OBJECTIVE:To provide reference for the development of online drugstores in China based on mobile port. METH-ODS:The development of online drugstores in China based on mobile port was analyzed by SWOT(strengths,weaknesses,oppor-tunities,threats)analysis to put forward suggestions. RESULTS & CONCLUSIONS:Online drugstores based mobile port included vertical management in which pharmaceutical E-commerce manager directly participate,non-vertical management which mainly pro-vide information inquiry and price comparison. It has advantage in breaking through time and space obstacle,optimizing informa-tion display,integrating consumer’s information accurately,improving human efficiency,etc. They are weak in timeliness,busi-ness scope and sale function,the quality of pharmaceutical care,user activity,etc. They have the opportunities as annual increase of mobile E-commerce market scale and huge market development potential;they also face various threats,such as the inconformi-ty between main users of mobile port and main purchasers,consumer low-trust,health-care polity barrier breakthrough failure,the lack of legal regulations for medical and pharmaceutical software,etc. It is suggested that companies operate further accurately and the government speed up the formulation and implementation of laws and regulations.

AIM:To discuss the causes and therapeutic measures of Descemet's membrane detachment during phacoemulsification ( Phaco) .
METHODS:A retrospective analysis of 997 patients who had operations of Phaco and intraocular lens ( IOL ) implantation at the eastern part of Yangzhou No. 1 People's Hospital during 2007-2012. The treatment and prognosis of 21 patients who had the complication of Descemet's membrane detachment during the surgery were observed.
RESULTS: The vision acuity of all the 21 patients had improved to different extent after therapy, no one had the decompensation of corneal endothelium.
CONCLUSION:Early detection and treatment is decisive for the vision acuity of the patients who had the Descemet's membrane detachment.

As a subset of Inhibitory T cells,CD4+ CD25+ Foxp3+ regulatory T (Treg) cells could strongly inhibit the activation,proliferation and function of effector T lymphocytes cells.Treg cells play an important role in downregulate autoimmune and mediating transplantation tolerance.Treg cells concerntrations could be markedly increased expression in tumor issues and peripheral blood of lung cancer.The clinical staging of lung cancer and lung cancer pathological types.Treg cells are important for lung cancer diagnosis and treatment.

Traditional Chinese medicineZhizi is the dry ripe fruit of Gardenia jasminoides Ellis, which belongs to the family of Rubiaceae. The main effective constituents of gardenia include iridoid, gardenia yellow pigment and organic acid. Modern pharmaco-logical studies showed that the main pharmacological effects of gardenia included anti-inflammatory, antipyretic and analgesic effects, liver protection, cholagogue, antilipidemic effect, antithrombus, nerve protection and anti-Alzheimer' s disease. In this paper, the ef-fective constituents and pharmacological effects of Gardenia jasminoides Ellis were reviewed to provide available information for further research.

Child ; Clinical Laboratory Techniques ; Humans ; Microbiological Techniques ; Viral Load ; Virus Cultivation ; Virus Diseases ; diagnosis

BACKGROUND:The studies about biomechanics of total knee arthroplasty were more, but the research on finite element analysis of the effect of total knee arthroplasty on proximal tibial reconstruction was not much.
OBJECTIVE:To study the effect of total knee arthroplasty on proximal tibial reconstruction using finite element analysis.
METHODS:We designed knee models of two materials:one was functional y graded material models of col agen and titanium composite materials;another was titanium al oy material model. We created two prosthesis material tibia-knee prosthesis model, and analyzed bone density distribution of proximal tibia, the maximum stress value of the medial tibia and the lateral tibia, and the maximum stress value of medial tibia and prosthesis junction, as wel as lateral tibia and prosthesis junction after knee arthroplasty.
RESULTS AND CONCLUSION:(1) Bone density of proximal tibia after total knee arthroplasty:The bone density of the knee prosthesis handle with medial and lateral tibia at the junction of tibial plateau was decreased than that of the initial state. Stress shielding effect was lower in col agen and titanium composite materials of functional y graded material models than that of titanium al oy material model. The bone density of shank end of the tibial prosthesis was obviously increased compared with the medial and lateral tibia, showing stress concentration. (2) The maximum stress value of the medial and the lateral tibia:The maximum stress value of the medial and the lateral tibia in col agen and titanium composite models was lower than that of titanium al oy material model. The maximum stress values of the lateral tibia of col agen and titanium composite models and titanium al oy material model were lower than that of medial tibia. (3) The maximum stress of medial tibia, lateral tibia and prosthesis junction:The stress distribution of col agen and titanium composite models was relatively uniform. The stress distribution of titanium al oy material model showed fluctuation. Stress concentration appeared in pal ets and prosthesis junction and the shank end of the prosthesis. The maximum stress values of lateral tibia and prosthesis junction of col agen and titanium composite models and titanium al oy material model were lower than that of medial tibia and prosthesis junction. (4) These findings showed that knee prosthesis has a certain stress shielding effect on tibia after total knee arthroplasty. The stress shielding effect of col agen and titanium composite material prosthesis was lower than titanium al oy material prosthesis, and could improve tibial incurred stress.

Objective: To investigate the inhibition of luteoloside on the proliferation of human esophageal carcinoma cell line Eca109 and its mechanism. Methods: MTT assay was used for detecting the influence of luteoloside at different concentration on the proliferation of Eca109. The morphological changes of cells were observed under inverted microscope. The cell cycle and apoptosis were detected by flow cytometry. RT-PCR was used to detect the mRNA expression of cyclin D1, survivin, and c-myc genes. Results: The results of MTT assay showed different doses (80, 120, 160, 200, and 240 μmol/L) of luteoloside could inhibit the cell proliferation of Eca109 cells in a dose-response manner. Luteoloside could also change the morphological characteristics of cells, reduce the cell size, and separate from peripheral cells. Treated with 240 μmol/L luteoloside, the cells were sprouting and some of them developed multiple pseudopodia-like protrusions. Treated with luteoloside (160 and 240 μmol/L), the cell cycle of Eca109 cells was blocked in G2/M phase and apoptosis was induced (P < 0.05). Compared with the control group, the gene expression of cyclin D1, survivin, and c-myc was decreased after treated with 240 μmol/L luteoloside for 48 h (P < 0.05). Conclusion: Luteoloside could significantly inhibit the proliferation of Eca109 cells by changing the cell cycle and inducing the apoptosis. Moreover, it could decrease the mRNA expression of relative genes.

Malignant lymphoma is a common malignant tumor of the lymphatic system. In recent years, immunotherapy is a new direction in the field of lymphoma treatment after targeted therapy, radiotherapy and chemotherapy. Immune checkpoint inhibitors (ICPi) have achieved significant efficacy in Hodgkin lymphoma (HL), with an overall response rate of about 80%, which makes the clinical application of ICPi in patients with malignant lymphoma become the focus of attention. This article reviews the recent progress in the biological mechanism of programmed cell death 1 (PD-1) and cytotoxic T lymphocyte-associated antigen (CTLA-4), and the application of ICPi in the treatment of HL and non-Hodgkin lymphoma.

Objective: The study examined adolescents' obedience,justifications,and feelings to parental authority as well as their interrelation in parent-adolescent conflict situations.Methods: 538 adolescents aged 10-to 18-year-old were investigated by questionnaires in light of different domains(personal,conventional,and friendship domains)selected from Smetana(2000).Results: ①The results suggested that their obedience to parental authority changed with different domains,as well as their justifications and feelings;②Adolescents' justifications of obedience focused on conventional rules,knowledgeable attributes,reciprocal relationships and physical consequences;③There were more negative feelings than neural or positive ones accompanied with their obedience;④Their justifications and feelings were different between obedience and disobedience groups,the conventional-rule-attribute was significantly correlated with negative feelings in both of obedience and disobedience groups,and the knowledgeable-attribute was significantly correlated with positive feelings in obedience group.Conclusion: Adolescents' conceptions of parental authority are domain-specific,and their obedience,justifications and feelings interrelate with each other.