Objective To study the effect of recombinant human thrombopoietin(rh TPO)for the treatment of post-chemotherapy thrombocytopenia in adult patients with acute myeloid leukemia(AML). Methods A total of 60 newly diagnesed AML patients ,law-and Intermediate-Rist with post-chemotherapy thrombocytopenia were randomly divided into experimental group (30 cases,rh TPO treatment)and control group(30 cases,no rhTPO treatment). Comparisons were made on the blood platelet recovery degree,the days of the blood platelet counting less than 20 × 109/L,the recovery days of the blood platelet counting more than 50 × 109/L,and incidence of adverse reac-tions of experimental group. Results After treatment,blood platelet recovery level between the experimental group and the control group has no difference(P>0.05). The days of the blood platelet counting less than 20 × 109/L and the recovery days of the blood platelet counting more than 50 × 109/L of experimental group were less than the control group separately(P < 0.05). The experimental group had low incidence of adverse reactions(6.7%). Conclusion rhTPO can not significantly increase the level of platelet recovery of AML patients after chemotherapy ,but can obvi-ously shorten the time of platelet recovery without obvious adverse reactions. The specific time needs further studied.

Phenylketonuria,an autosomal recessive inherited disease characterized by amino acid metabolism abnormality,has been listed as a screening program for neonatal genetic metabolic diseases in China.Eearly screening and treatment can reduce or even avoid the disease,However,delayed intervention can influence social functioning and psychological development.The research of life quality including psychological and social functioning in phenylketonuria patients has atlracted the increasing attention along with the medical model transformation.In order to study quality of life in patients with phenylketonuria,life quality questionnaires have been developed.It reveals that early and long-term treatments can improve the quality of life.The assessment and present condition as well as the impact factors of quality of life in phenylketonuria patients have been reviewed in this article,which have important value to evaluate the quality of life and guide clinical treatments as well as judge the prognosis of patients with phenylketonuria.

Objective To investigate the safety and feasibility of laparoscopic surgery in the treatment of common bile duct stones after subtotal gastrectomy.Methods A retrospective analysis was performed for the clinical data of 46 patients with gallstones and common bile duct stones after subtotal gastrectomy who underwent surgical treatment in Luoyang Central Hospital Affiliated to Zhengzhou University from January 2010 to October 2016.Among these patients,25 underwent laparoscopic cholecystectomy + common bile duct exploration (laparoscopic group),and 21 underwent open cholecystectomy + common bile duct exploration (open group).The surgical conditions and postoperative complications were compared between the two groups.The t-test was used for comparison of continuous data between groups,and the chi-square test was used for comparison of categorical data between groups.Results No patients died during the perioperative period and 2 patients (8.0％) in the laparoscopic group were converted to open surgery.There were significant differences between the laparoscopic group and the open group in time to ambulation after surgery (1.2 ± 0.6 d vs 2.4 ± 1.2 d,t =4.395,P ＜ 0.001),time to passage of gas by anus after surgery (1.8 ±0.5 d vs 2.8 ±0.8 d,t =5.168,P ＜0.001),and length of postoperative hospital stay (5.2 ± 1.1 d vs 7.5 ±2.3 d,t =4.439,P ＜ 0.001).There were no significant differences between the two groups in time of operation,intraoperative blood loss,hospital costs,T tube placement,and rate of residual stones (all P ＞ 0.05).After surgery,2 patients (8.0％) in the laparoscopic group and 3 (14.3％) in the open group experienced complications,and there was no significant difference between the two groups (P =0.495).Conclusion Laparoscopic surgery is safe and feasible in the treatment of common bile duct stones after subtotal gastrectomy and has the advantages of minimally invasive surgery.

Cardiovascular disease (CVD) is a leading global cause of mortality and morbidity. Risk assessment of asymptomatic individuals plays an important role in the primary prevention of CVD and its complications by guiding management decisions, in particular the decision to use statins or antiplatelet agents, as well as more controversially, the target level for risk factors such as hypertension and cholesterol. Timely and regular risk assessments also identify the development of physiological disturbances such as pre-hypertension, pre-diabetes, dyslipidaemias, clinical obesity and metabolic syndrome, which can be asymptomatic in the early stages, but may lead to increased risk for many ageing-related degenerative diseases, including CVD. These physiological mal-adaptations are remarkably responsive to behavioural lifestyle interventions at an early stage, and may be stabilised or even reversed without medications. This article describes the why and how of assessing CVD risk and a suggested framework for management, including the appropriate use of behavioural lifestyle interventions as first-line treatment. It also describes the various risk scores available, their differences and limitations and how to best use them in clinical practice. More research is required regarding the use of non-traditional and emerging markers of CVD risk such as carotid intima-media thickness, coronary artery calcium scoring, hsCRP, ankle brachial index, Apo-B, albuminuria, and how they may be incorporated into existing risk models.

Autosomal dominant optic atrophy(ADOA),also called Kjer-type optic atrophy,is the most decrease of visual acuity,color vision deficit,visual field defects,and it is also characterized by temporal pallor of the optic disc.Deafness,cataract,ophthalmoplegia,ptosis and so on,can also accompany ADOA.Up to now,it has been verified that four known genetic loci are associated with ADOA,including OPA1(3q28-29),OPA3(19q13.2-13.3),OPA4(18q12.2-12.3)and OPA5(22q12.1-13.1).The OPA1 and OPA3 genes have been cloned.But genotypephenotype correlations and pathogenic mechanisms of ADOA are not very clear.The recent researches about clinical features,relevant candidate gene and loci,differentiation diagnosis were reviewed.

Objective:To study the expression of cbf?1 on mouse MDPC-23 cell line,and discuss the role of cbf?1 in the regulation of dental embryo development. Methods:By transient transfection,immunofluorescence,and western blot,the expression of cbf?1 on mouse MDPC-23 cells were studied. Results:The control MDPC-23 cells didn't express cbf?1.After transient transfected for 48 h,cbf?l expression was significantlly increased.BMP_(2)could induce low level expression of cbf?1. Conclusion:cbf?l expression was significantly increased 48h after transient transfection.

Basic English is the cornerstone that built the bridge between the world and the national treasure,the Traditional Chinese Medicine (TCM).With the increasing internationalization of the TCM,higher requirement is put forward by the society to the students as well as English teachers.In this paper,from the angle of students,author analyzes some problems in English teaching in the college of TCM.Meanwhile,author concludes some experiences from these years of teaching practices for solving those problems.

The theory of multiple intelligences put forward by Gardner has brought us enlightenment in different aspects.The theory maintains that every individual has eight intelligences,among which the advantageous one may be transferred to the others in a certain situation,and this greatly inspires multimedia EFL teaching at college.

Concluded from the research,the main stream of current medical university students'concept of honor and disgrace is positive,including correct political conviction and good outlook on life.However,at the same time there also exist some negative aspects,such as wrong ideas on world outlook,value concept,moral concept and legal outlook.The negligence of school education and the negative influence of social environment are the main reasons.

Current researches have provided theoretical basis.Problems in life education and the corresponding strategies are proposed to boost the quality of life education.