Objective]To investigate the effect of improving the treatment of hyperlipidemia simvastatin treatment. [Methods] From October 2012 to February 2014 in our hospital 80 cases of patients with hyperlipidemia were randomly divided into four groups, each of 20 cases, namely group A (simvastatin), group B(Xinmaitong capsule and simvastatin), group C(acupuncture and simvastatin group) and group D(acupuncture, Xinmaitong capsule and simvastatin group), for 1 consecutive month of treatment, patients were observed before and after total cholesterol, triglycerides esters, LDL and HDL changes. [Results] Group A was 70%;the effective rate was 85% in group B; group C, the effective rate was 80%; D group was 95%, the difference was statistically significant(P<0.05), and the combined group of high-density lipoprotein increased significantly. [Conclusion] Combination therapy medicine was more efficient than single, the enhanced effect of high-density lipoprotein was obvious, what ’s more,the effect of acupuncture, Xinmaitong capsule and simvastatin group was better than others.

Objective]To observe and understand the effect and mechanism of QingReYangYin Recipe(QRYYR) on the ovary hormone level and mRNA expressions of PI3K and PKB in adipose tissue around womb and ovary in rat model of polycystic ovary syndrome(PCOS).[Methods]Rat PCOS model was established by Poretsky method and divided randomly into four groups: model group, western medicine group,low dose QRYYR group and high dose QRYYR group. Normal rats were used as normal group. All rats were orally administrated for 14 days and were weighed every day.After 14 days treatment, serum sample of each rat was obtained for analysis of estradiol(E2),progesterone(P), testosterone(T) contents. Each ovary was collected and weighed for measurement of the ovarian index. The fat pad around womb and ovary was obtained for analyzing the mRNA expressions of PI3K and PKB by PCR. [Results]Compared with the model group, the serum E2 and P levels in QRYYR group were significantly higher but T level was significantly lower(P<0.05) than the model group. The levels of E2, P and T in high dose QRYYR group had no difference from that in the western medicine group and the normal group(P>0.05).The ovarian index in the QRYYR groups was significantly decreased as compared with the model group(P<0.05),and that in the high dose QRYYR groups had no difference with the normal group(P>0.05).The mRNA expressions of PI3K and PKB were significantly increased in the QRYYR groups as compared with the model group(P<0.05),and the expressions in high dose QRYYR group, western medicine group and the normal group had no significant difference from each other(P>0.05). [Conclusion] QRYYR could significantly increase the content of E2 and P in the rat serum, significantly decrease the content of T and the ovarian index. Meanwhile, it could significantly increase the mRNA expressions of PI3K and PKB in adipose tissue. It could improve the ovarian function and decrease the local insulin resistance. The effect of the high dosage group on PCOS was superior or similar to Metformin.

A series of changes of maternal thyroid hormones occur during pregnancy.The growth and development of offspring,especially the growth of the thyroid gland,depends a lot on maternal normal thyroid function.If the thyroid dysfunction of pregnant women is not diagnosed and treated properly,the children may suffer with serious consequences,including fetal loss (abortion,stillbirth),premature birth,congenital malformation,hyperthyroidism or hypothyroidism,delayed development of the nervous system,etc.Maternal thyroid dysfunction even influences the long-term growth of offspring.Therefore,we should detect and control thyroid dysfunction of pregnant women and their children as early as possible,in order to improve the survival rate and life quality of the offspring.

Traditional Chinese medicineZhizi is the dry ripe fruit of Gardenia jasminoides Ellis, which belongs to the family of Rubiaceae. The main effective constituents of gardenia include iridoid, gardenia yellow pigment and organic acid. Modern pharmaco-logical studies showed that the main pharmacological effects of gardenia included anti-inflammatory, antipyretic and analgesic effects, liver protection, cholagogue, antilipidemic effect, antithrombus, nerve protection and anti-Alzheimer' s disease. In this paper, the ef-fective constituents and pharmacological effects of Gardenia jasminoides Ellis were reviewed to provide available information for further research.

Pneumonia is the primary cause of death in children under five-years old.About 2 million children younger than 5 years die of pneumonia each year worldwide,accounting for 19％ of the total number of deaths.According to the survey in 2008,7％ to 13％ of the children with pneumonia were severe pneumonia.Currently,the early diagnosis and treatment of severe pneumonia is often difficult.In order to improve the early diagnosis an prognosis cognition level of severe pneumonia,here is to make a review on the recent literatures on the biomarkers like brain natriuretic peptide,D-Dimer,C-reactive protein,lactate,zinc,procalcitoin,prealbumin,platelet count,endothelin-1 and high mobility group box 1 in children with severe pneumonia.

OBJECTIVE: To analyze the situation and the related problems of Chinese patent drugs including toxicity components used in pediatrics, and to provide the suggestion for the development of Chinese patent drugs for pediatrics. METHODS: 264 Chinese patent drugs which were used in pediatrics were collected from national drug standards, and compared with toxicity drug list. The utilization of toxicity drugs were analyzed statistically. RESULTS: About half of Chinese patent drugs for pediatric included toxicity components. Major problems are complex resource of toxicity components, overdose of toxicity components, single disease and pattern, unscientific determination of amount, etc. CONCLUSION: The in-depth study of Chinese patent drugs requires perfecting national drug standards, to developing more rigorous special approval requirements, to establishing the re-evaluation system and to eliminating unsuitable category of Chinese patent drugs.

OBJECTIVE:To establish quality criteria for Bushenqiangshen capsule. METHODS:TLC was employed to identify Herba Epimedii and Fructus Ligustri Lucidi. HPLC was applied for the determination of content of Icariin. The chromatographic separation was performed on octadecylsilane chemically bonded silica packed column (250mm?4.6mm,5?m). The mobile phase was composed of acetonitrile and methyl alcohol (30∶70) at a flow rate of 1.0mL?min-1. The detection wavelength was 270nm and the column temperature was 30℃. RESULTS:Herba Epimedii and Fructus Ligustri Lucidi were well-separated and clear spots were noted in their TLC. The linear range of icariin was 0.266 4～0.932 4?g (r=0.999 9,n=6), and the average recoveries was 99.77%(RSD=1.89%). CONCLUSION:The established criteria can be used for the quality control of Bushenqiangshen capsules.

Objective To describe the status of resilience and self-care behaviors in chronic heart failure patients and to explore the relationship between resilience and self-care behaviors. Methods It was a cross-sectional survey. The Connor-Davidson Resilience Scale, the self-care behaviors with heart failure questionnaire and the demographic scale were delivered to 150 chronic heart failure patients in Shanghai Changhai Hospital. Results The score of self-care behaviors was (2.63 ± 2.01) points for chronic heart failure patients. The resilience score was (57.56 ± 8.51) points. The resilience was significantly related to the self-care behaviors(r=0.427, P<0.01), and which explained 32.4%of the total variation. Conclusions The chronic heart failure patients have poor self-care behaviors and resilience. More attention should be paid and more action be taken to improve the resilience, then improve the self-care behaviors of patients.

OBJECTIVE:To improve the teaching quality of Natural Medicine Foundation and help students better grasp the ba-sic skills of distinguishing common natural medicines. METHODS:Comparison method was used to integrate teaching contents and organize classroom teaching,and the effectiveness of teaching was evaluated. RESULTS:The traditional teaching material system was broke to integrate comparable content together by comparing the common and difference to integrate the content of the compara-bility,comparison of differences in similarities included the comparison of herbal medicinal parts of similar finishing,the compari-son of Chinese medicinal herbs with the same typical characters;comparison of differences in similarities included the comparison of similar overall properties of the herbs,characters of traditional Chinese medicinal materials from different sources,drug name medicine approximation comparison,precious medicinal herbs genuine and counterfeit goods traits. Infiltration comparison method was used in different types of courses and the teaching of different teaching links to guide students to learn to use the comparative thinking to obtain knowledge. CONCLUSIONS:According to the application of comparative method in the teoching of Natural Med-icine Foundation,students have improved the performance and learning ability. It is suggested to apply the comparative method moderately and timely and insist in student-centered,in addition,comparative method shoud be researched and applied with develop-ment view.

This paper probes into problems about the change of hospital economic interest and moral relation etc. brought by trying out medical insurance system in Zhengjiang, Jiujiang City. Also in points out that economic states have influence on ethical concept. Ethical concepts have a role on economic behaviour, which are two sides of cause and effect chain. For these reasons, medical insurance system is mutual movement results of economic & ethical factors, It can coordinate the relationships between hospital economic interest and morality embody medical service fairness and economic moral principles.