Objective To investigate the relationship between the single nucleotide polymorphism in exon 7(G894T) or the insert/deletion polymorphism of variable number of tandem repeat in intron 4(4b/a) of the endothelial constitutive nitric oxide synthase(ecNOS) gene and the coronary disease in patients with type 2 diabetes.Methods In 80 patients with type 2 diabetes(group DM),92 type 2 diabetic patients with coronary disease(group DH) and 119 healthy controls(group NC),the polymorphism G894T was determined by polymerase chain reaction-restriction fragment length polymorphism analysis, while the polymorphism 4b/a was determined by polymerase chain reaction-variable number of tandem repeat analysis.Results The frequencies of allele T or genotype containing with allele T(GT or TT) in group DH were significantly higher than those in group DM or group NC(all P

In patient with primary biliary cirrhosis,the metabolism of calcium and vitamin D could be affected and osteomalacia and secondary hyperparathyroidism might occurr.Besides,hypoalbuminemia may mask the real level of serum calcium and thus lead to misdiagnosis of coexisting parathyroid adenoma.Therefore,a rare case of parathyroid adenoma associated with primary biliary cirrhosis was herewith presented to call attention to the effect of hypoalbuminemia on serum calcium.

Objective To explore the clinical therapeutic effect of inverted DHS and PFNA in the treatment of femoral intertrochanteric fractures. Methods A total of 97 patients with intertrochanteric fracture in our hospital from Mar. 2011 to Mar 2013 in the department of orthopaedics were randomly divided into two groups. 48 cases were included into DHS group,another 49 cases were included into PFNA group.And then the perioperative index and the average healing time,postoperative fracture reduction loss, the excellent rate of joint function recovery and the incidence of complications between the two groups were compared. Results Theoperative time,intra-operative blood loss,postopera-tive drainage,the average healing time of PFNA group were better than that in DHS group (P<0.05).The postoperative fracture reduction loss,complication incidence of PFNA group was significantly lower than that in DHS group,and the excellent rate of joint function recovery of PFNA group was significantly higher than that in DHS group (P<0.05). Conclusion PFNA is a reliable and effective therapy for femoral intertrochanteric fractures,it is of worthy of clinical application.

Objective This study was conducted to analyze the clinical characteristics and pituitary function of patients with primary empty sella (PES).Methods The clinical data from 123 hospitalized adult patients with PES from January 2010 to May 2016 were retrospectively studied.Results (1) The average age of the 123 (male 43,female 80) PES patients was (59.2 ± 13.6) years (ranging 24-92 years),among whom 61％ patients were in the age group between 50-69 years.(2) The symptoms of the patients included fatigue (56.1％),headache (34.1％),nausea and vomiting (17.9％),gonadal dysfunction (17.1％),visual disturbance (5.7％) and hypopituitarism crisis (3.3％).(3) Hypopituitarism was found in 66 of the 123 patients.Among them,36.6％,31.7％ and 17.1％ were central hypoadrenalism,hypogonadism,and hypothyroidism,respectively.The percentage of hypopituitarism in complete PES was significantly higher than that in partial PES (P ＜ 0.05).(4) Sixteen patients were concomitant with other autoimmune diseases including 11 patients with Graves' disease and 2 with Cushing's syndrome due to adrenal adenoma.Conclusions The incidence of hypopituitarism in PES was 53.7％,in which the pituitary-adrenal axis hypofunction was more common.An overall evaluation of the pituitary function was essential for the patients who had headache and fatigue,or with suspected PES.The patients with hypopituitarism should be given hormone replacement therapy in time and followed up afterword.