Hypertrophic cardiomyopathy(HCM)is an inherited cardiomyopathy characterized by left ventricular hypertrophy without ventricular enlargement,which is one of the main causes of athletic sudden death in adolescents. Early detection of symptoms and timely diagnosis and treatment are of great value in preventing athletic sudden death and improving the prognosis. The diagnosis of HCM is based on medical history,physical examination and echocardiography,as well as family history and genetic testing in recent years. In recent years,cardiac magnetic resonance(CMR)and CT examination have become more and more important in the diagnosis of HCM. The aim of the article is to explore the characteristics of CMR and CT in the diagnosis of HCM.

OBJECTIVE: To investigate the influence of pre-pregnancy parental body mass index (BMI), maternal weight gain during pregnancy, and their interaction on neonatal birth weight. METHODS: A total of 1 127 pregnant women who underwent regular prenatal examinations and full-term singleton delivery in the First Hospital of Xi'an Jiaotong University from January 2017 to October 2018 were enrolled. The data on their pre-pregnancy BMI, maternal weight gain during pregnancy, pre-pregnancy BMI of the husband, and neonatal birth weight were collected. The interaction between pre-pregnancy parental BMI and maternal weight gain during pregnancy was analyzed, and their correlation with neonatal birth weight was analyzed. RESULTS: Among the 1 127 full-term neonates, the detection rates of low birth weight neonates and macrosomia were 2.22% (25/1 127) and 3.82% (43/1 127) respectively. There were significant differences in pre-pregnancy parental BMI and maternal weight gain during pregnancy among the low birth weight, normal birth weight, and macrosomia groups (P<0.05). Neonatal birth weight was positively correlated with pre-pregnancy parental BMI and maternal weight gain during pregnancy (r=0.097-0.322, P<0.05). Low maternal weight before pregnancy increased the risk of low birth weight (RR=4.17, 95%CI: 1.86-9.38), and maternal overweight/obesity before pregnancy (RR=3.59, 95%CI: 1.93-6.67) and excessive weight gain during pregnancy (RR=3.21, 95%CI: 1.39-7.37) increased the risk of macrosomia. No interaction between pre-pregnancy maternal BMI and maternal weight gain during pregnancy was observed. CONCLUSIONS Pre-pregnancy parental BMI and maternal weight gain during pregnancy are related to neonatal birth weight, and there is no interaction between pre-pregnancy maternal BMI and maternal weight gain during pregnancy.
Birth Weight ; Body Mass Index ; Female ; Gestational Weight Gain ; Humans ; Infant, Newborn ; Pregnancy ; Pregnancy Complications ; Risk Factors ; Weight Gain

Humans ; Uric Acid ; Sleep Apnea, Obstructive ; Risk Factors

Objective:To investigate the safety and efficacy of sacral neuromodulation(SNM)therapy for the treatment of lower urinary tract dysfunction(LUTD)in elderly patients.Methods:Clinical data of 91 elderly patients with LUTD from multiple medical institutions who received SNM during the period from January 2012 to December 2016 were retrospectively analyzed.Patients were divided into four groups: the interstitial cystitis(IC)group(n=28), the neurogenic bladder(NB)group(n=36), the overactive bladder syndrome(OAB)group(n=13)and the idiopathic dysuria(ID)group(n=14). Different sets of evaluation parameters were used for different diseases.Patients’ baseline data and data in stage I(test phase)and stage Ⅱ(permanent SNM)were recorded, statistically analyzed and compared.Results:Ninety-one people underwent SNM treatment.Of them, 53 patients received permanent implants(stage Ⅱ), and the total conversion rate of stage I to stage Ⅱ was 58.2%(53/91). Patients receiving permanent implants(stage Ⅱ)had a preoperative period ranging from 3 months to 30 years, and were followed up for 2 to 58 months after treatment, with an average follow-up of 19.6 months.The improvement rates in stage I for urinary urgency, daily urination frequency, daily nocturnal urination frequency, maximum urine volume, daily average urine volume, daily urine leakage frequency, and quality of life score were 35.4%, 31.6%, 33.7%, 32.6%, 49.2%, 43.2% and 13.2%, respectively.The improvement rates in stage Ⅱ for urinary urgency, daily urination frequency, daily nocturnal urination frequency, maximum urine volume, daily average urine volume, daily urine leakage frequency, and quality of life score were 43.2%, 40.0%, 37.8%, 50.5%, 70.5%, 70.4% and 43.2%, respectively.Three adverse events occurred, including 1 case of recurrent symptoms, 1 case of moderate infection, and 1 case of electrical lead dislocation.Conclusions:Sacral nerve stimulation has definitive and consistent curative effects on LUTD in elderly people.The follow-up time should be extended to further study the safety of sacral nerve stimulation.

OBJECTIVE: To explore the effects and results of temporary cardiac pacing in children with bradyarrhythmia.METHODS: The clinical data of 55 children with bradyarrhythmia who received temporary cardiac pacing between June2007 and May 2018 in Children's Hospital of Chongqing Medical University were analyzed retrospectively. The clinical characteristics and curative effects were summarized and statistically analyzed. RESULTS: A total of 55 cases of bradyarrhythmia included 29 cases of severe atrioventricular block(AVB),sinus bradycardia or cardiac arrest caused by myocarditis,5 cases of Ⅲ°AVB or sick sinus syndrome caused by cardiomyopathy,6 cases of Ⅲ°AVB caused by congenital heart disease after surgery,5 cases of congenital Ⅲ°AVB,and 10 cases of perioperative temporary pacing Ⅲ°AVB.Among them,39 cases were compared in Adams-Stokes syndrome(P=0.003),34 cases were compared in ejection fraction and fractional shortening(P=0.000,P=0.001),and 26 patients were compared in left ventricular end diastolic diameter(P=0.001)before and after temporary pacing,and there were statistically differences. After treatment,18 cases were clinically cured,36 cases were improved,and 1 case died,among which 45% arrhythmia were improved or recovered,and 10 cases of perioperative children all passed through the anesthesia period. Kruskal-Wallis H(K)test showed that the clinical and arrhythmia prognosis of different basic cardiovascular diseases were not completely the same(P=0.001,P=0.000);Mann-Whitney U test indicated a better prognosis in the myocarditis group(P=0.001,P=0.000).CONCLUSION: Temporary cardiac pacing can effectively relieve the clinical symptoms of severe bradyarrhythmia caused by various etiologies,promote the recovery of acute conduction system injury,and reduce Ⅲ°AVB perioperative risk.Temporary cardiac pacing is a safe and effective prevention and first-aid technique.