1.A Clinical Study of Tic Disorder in Korea.
Journal of the Korean Pediatric Society 1981;24(3):198-208
No abstract available.
Korea*
;
Tic Disorders*
;
Tics*
2.A Case of Sjögren Syndrome Involving Central Nervous System with Phonic Tic.
Journal of the Korean Neurological Association 2016;34(2):162-164
No abstract available.
Central Nervous System*
;
Sjogren's Syndrome
;
Tics*
3.A Study of Human Melanocytes Culture.
Ki Ho LEE ; Mu Hyoung LEE ; Jai Kyung PARK ; Choong Rim HAW
Korean Journal of Dermatology 1990;28(2):136-146
The author evaluated the optimal concentration of 3 compositions of TIC medium which has used as the melanacytes culture medium. The concentrations of placental extract and bovine pituitary extract, which have the ability to promote proliferation of melanocytes, were evaluated also. Modified TIC medium with above 5 components of evaluated concentration was very effective in melanocytes culture. The results were as follows : l. 12-0-tetradecanoyl-phorbol-13-acetate (TPA) showed effective melanocytes proliferating activity at the concentration of 30ngml (p(0.05) 2. Isobutylmet:hyl xanthine (IBMX) showed effective melanocytes proliferating activity at the concentration of 0.3mM (p(0.05) 3. Cholera toxin (CT) showed effective melanocytes proliferating activity at the concentration of )OnM (p(0.05) 4. Two percentages of placental extract in culture medium showed effective melanocytes proliferating activity. S. Two percentages of bovine pituitary extract in culture medium showed effective melanocytes proliferating activity. 6. Placental extract and isobutylmethyl xanthine proved to have high melanocytes proliferating activity. 7. Melanocytes proliferated rapidly on modified TIC medium (Proliferation doubling time . about 43 hours) 8. The peak time of melanocytes proliferation (7.2 X 10/cm) was observed on the seventh day of culture, From this data, this culture system can be recommended as a new melanocytes culture.
Cholera Toxin
;
Humans*
;
Melanocytes*
;
Tics
;
Xanthine
4.Treatment of Washboard Nail with Topical Tacrolimus Ointment.
Han Eul LEE ; Hong Ki CHO ; Sung Yul LEE ; Jong Suk LEE ; Young Lip PARK ; Kyu Uang WHANG
Korean Journal of Dermatology 2012;50(12):1054-1056
Washboard nail is a dystrophy that presents as a series of ridges that extends across the nail. It is often accompanied by a central depression that extends from the cuticle to the free edge. Washboard nail is often a result of frequently repeated trauma, but sometimes predisposing factors cannot be found. When habitual tic is the cause of the lesions, restraining the habit is the most important treatment. Here, we report a case of a 6-year-old male with washboard nails on both thumbnails and was treated with topical 0.1% tacrolimus ointment. Significant improvement was observed after 4 months of application. This case suggests that topical tacrolimus can be considered as a primary therapy in the treatment of washboard nails in the absence of trauma.
Depression
;
Humans
;
Male
;
Nails
;
Tacrolimus
;
Tics
5.Misdiagnosis of eyelid myoclonia as Tic's disorder: a case report.
Yan SUN ; Hao CHEN ; Hao CHANG ; Yi ZHU
Chinese Journal of Pediatrics 2004;42(11):839-839
6.Development of the Korean Form of Yale Global Tic Severity Scale: A Validity and Reliability Study.
Sun Ju CHUNG ; Jeoung Seop LEE ; Tae Ik YOO ; Young Jin KOO ; Seong Ill JEON ; Bong Seok KIM ; Kang E HONG
Journal of Korean Neuropsychiatric Association 1998;37(5):942-951
OBJECTIVES: This study was carried out to develop the Korean form of Yale Global Tic Severity Scale(YGTSS)-family & clinical rating version. The severity of motor and phonic tics was rated according to five separate dimensions : number, frequency, intensity, complexity,and interference. METHODS: The Korean form of YGTSS was applied to 100 children who visited psychiatric outpatient clinic with chief complaints of tic symptom. Together with YGTSS, Clinical Global Impression for Tourette's syndrome(CGI-TS), Obsessive-Compulsive disorder(CGI-OCD), At tention-Deficit/Hyperactivity Disorder(CGI-ADHD) were administered to all subjects for examining convergent and discriminant validities. RESULTS: We could confirm high internal consistency, convergent and discriminant validities and interrater reliability of YGTSS by analysing data from 100 children with tic disorder. In factor analysis, items were clusterd to 2 factors which were identical motor and phonic tic subscales. CONCLUSION : The results of this study indicate that the Korean form of YGTSS is a reliable and valid rating scale for rating tic symptom severity. It can be used to evaluate tic symptom objectively and to quantify the tic severity in the studies for tic disorder.
Ambulatory Care Facilities
;
Child
;
Humans
;
Reproducibility of Results*
;
Tic Disorders
;
Tics*
7.Effect of L - tyrosine on Proliferation and Melanization in Cultured Normal Human Melanocytes.
Mu Hyoung LEE ; Jin Hwan KIM ; Jai Kyung PARK ; Choong Rim HAW
Korean Journal of Dermatology 1996;34(1):25-30
BACKGROUND: The biosynthesis of melanin is initiated by the enzymatic oxidation of L-tyrosine to L-dopa by tyrosinase. Some precursors of melanin are cytotoxic, and melanoma cells are killed as a risk of exposare to excess tyrosine or dopa in the culture medium. However, there have been few observations of the effects of L-tyrosine on cultured normal human melanocyte. OBJECTIVE: In order to investigate whether exogenous tyrosine induces cytotoxicity in cultured normal human melanocytes as in melanoma cells, we examined the effects of L-tyrosine on proliferation and melanization in normal human melanocytes. METHODS: A melanocyte culture was produced with a modified TIC medium. L-tyrosine was added to the culture medium, 100, 200, 400, and 800uM. After 2 days of incubation, the proliferation was measured by methylthiazol tetrazolium(MTT) assay and sulforhodamine B(SRB) assay. The melanin contenis were also measured by the modified Whittaker's method. RESULTS: On MTT assay, the proliferation of melanocytes had been stirnulated significantly (p< 0.05) in all L-tyrosine added groups. On SRB assay, the proliferation of melanocytes had heen stimulated significantly (p<005) in 200, 400, 800uM of L-tyrosine added groups. The melanin contents had increased in all L-tyrosine added groups, and had increased significantly (p<0.05) in 400uM of L-tyrosine added group. CONCLUSION: L-tyrosine is not toxic to normal melanocytes, It stimulates the proliferation and melnization of cultured normal human melanocytes.
Dihydroxyphenylalanine
;
Humans*
;
Levodopa
;
Melanins
;
Melanocytes*
;
Melanoma
;
Monophenol Monooxygenase
;
Tics
;
Tyrosine*
8.Effect of L - tyrosine on Proliferation and Melanization in Cultured Normal Human Melanocytes.
Mu Hyoung LEE ; Jin Hwan KIM ; Jai Kyung PARK ; Choong Rim HAW
Korean Journal of Dermatology 1996;34(1):25-30
BACKGROUND: The biosynthesis of melanin is initiated by the enzymatic oxidation of L-tyrosine to L-dopa by tyrosinase. Some precursors of melanin are cytotoxic, and melanoma cells are killed as a risk of exposare to excess tyrosine or dopa in the culture medium. However, there have been few observations of the effects of L-tyrosine on cultured normal human melanocyte. OBJECTIVE: In order to investigate whether exogenous tyrosine induces cytotoxicity in cultured normal human melanocytes as in melanoma cells, we examined the effects of L-tyrosine on proliferation and melanization in normal human melanocytes. METHODS: A melanocyte culture was produced with a modified TIC medium. L-tyrosine was added to the culture medium, 100, 200, 400, and 800uM. After 2 days of incubation, the proliferation was measured by methylthiazol tetrazolium(MTT) assay and sulforhodamine B(SRB) assay. The melanin contenis were also measured by the modified Whittaker's method. RESULTS: On MTT assay, the proliferation of melanocytes had been stirnulated significantly (p< 0.05) in all L-tyrosine added groups. On SRB assay, the proliferation of melanocytes had heen stimulated significantly (p<005) in 200, 400, 800uM of L-tyrosine added groups. The melanin contents had increased in all L-tyrosine added groups, and had increased significantly (p<0.05) in 400uM of L-tyrosine added group. CONCLUSION: L-tyrosine is not toxic to normal melanocytes, It stimulates the proliferation and melnization of cultured normal human melanocytes.
Dihydroxyphenylalanine
;
Humans*
;
Levodopa
;
Melanins
;
Melanocytes*
;
Melanoma
;
Monophenol Monooxygenase
;
Tics
;
Tyrosine*
9.Safety and Tolerability of OROS Methylphenidate for the Treatment of ADHD.
Hyo Won KIM ; Bock Ja KO ; Tae Won PARK ; Yun O SHIN ; Jeong Seop LEE ; Un Sun CHUNG ; In Hee CHO ; Tae Young CHOI ; Geon Ho BAHN
Journal of the Korean Academy of Child and Adolescent Psychiatry 2012;23(Suppl):S24-S45
We review the effect of methylphenidate, focusing on Osmotic-controlled Release Oral delivery System (OROS) methylphenidate, on cardiovascular system, appetite and growth, sleep, tic, epilepsy, psychiatric and rare adverse events. Although OROS methylphenidate has side effects including increased heart rate or blood pressure, decreased appetite, delayed sleep onset, emergence or aggravation of tics, withdrawal or changes in mood, these effects appeared to be minimal in impact or difficult to distinguish from risk to untreated population and tended to be improved by dose adjustment or drug discontinuation. However, in subjects with underlying cardiac problems, uncontrolled epilepsy, previous psychotic episode, clinicians should pay attention and balance the risk and benefit.
Appetite
;
Blood Pressure
;
Cardiovascular System
;
Epilepsy
;
Heart Rate
;
Methylphenidate
;
Tics
10.Safety and Tolerability of OROS Methylphenidate for the Treatment of ADHD.
Hyo Won KIM ; Bock Ja KO ; Tae Won PARK ; Yun O SHIN ; Jeong Seop LEE ; Un Sun CHUNG ; In Hee CHO ; Tae Young CHOI ; Geon Ho BAHN
Journal of the Korean Academy of Child and Adolescent Psychiatry 2012;23(Suppl):S24-S45
We review the effect of methylphenidate, focusing on Osmotic-controlled Release Oral delivery System (OROS) methylphenidate, on cardiovascular system, appetite and growth, sleep, tic, epilepsy, psychiatric and rare adverse events. Although OROS methylphenidate has side effects including increased heart rate or blood pressure, decreased appetite, delayed sleep onset, emergence or aggravation of tics, withdrawal or changes in mood, these effects appeared to be minimal in impact or difficult to distinguish from risk to untreated population and tended to be improved by dose adjustment or drug discontinuation. However, in subjects with underlying cardiac problems, uncontrolled epilepsy, previous psychotic episode, clinicians should pay attention and balance the risk and benefit.
Appetite
;
Blood Pressure
;
Cardiovascular System
;
Epilepsy
;
Heart Rate
;
Methylphenidate
;
Tics